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NEONATAL BILIOUS
VOMITING- Part 2
A PROBLEM ORIENTED
APPROACH
Dr.B.Selvaraj MS;Mch; FICS;
Professor of Surgery
Melaka Manipal Medical College
Melaka 75150 Malaysia
OBJECTIVES
To discuss the differential diagnosis of
biliary emesis in neonates
To do appropriate workup to confirm the
diagnosis
To select the various treatment options
To make you confident in managing a
newborn with bilious vomiting
Neonatal Bilious Vomiting-Causes
Meconium Peritonitis
Necrotising Enterocolitis
Hirschsprung’s Disease
Anorectal Malformation
Rarely Mesentric Cyst &
Intestinal Duplication
Incarcerated inguinal hernia
Duodenal atresia/stenosis
Annular Pancreas
Malrotation&MGV
Intestinal Atresia:
Jejunal&Ileal
Meconium Ileus
Meconium Plug
Neonatal Bilious Vomiting-Causes
•MALROTATION & MGV
•MESENTRIC CYST& DUPLICATION
CYST
•CONGENITAL BANDS LIKE VI DUCT
BANDS
•MECONIUM ILEUS
•MECONIUM PLUG
•MECONIUM PERITONITIS
EXTRINSIC
•DUODENAL ATRESIA/STENOSIS
•JEJUNAL/ILEAL ATRESIA
•HIRSCHSPRUNG’S DISEASE
•NECROTISING ENTEROCOLITIS
CAUSES
MURAL
INTRA
LUMINAL
HIRSCHSPRUNG’S DISEASE
Craniocaudal migration of ganglion cells of the bowel
begins at 12th wk of gestation
Arrest of this migration produces an aganglionic segment
of bowel-absence of Aurbach’s & Meissener’s plexus
This aganglionic segment of bowel unable to relax &
peristaltic wave stops proximally- functional obstruction
Incidence 1 in 5000
Male:Female 4:1
HIRSCHSPRUNG’S DISEASE
Mutations in RET proto-oncogene are commonly
associated with Hirschsprung’s disease
Not passed/ delayed passage of meconium
Abdominal distension
Bilious vomiting
Fever & diarrhea suggest Toxic megacolon
HIRSCHSPRUNG’S DISEASE
Classification
HIRSCHSPRUNG’S DISEASE
Workup
AXR: Dilated Bowel
Loops
Barium Enema: Swan Neck
Appearance
HIRSCHSPRUNG’S DISEASE
Workup
Absence of
ganglion cells
in myenteric
plexus
Suction rectal bx
Noblet Rectal Mucosal
Suction Biopsy Gun
HIRSCHSPRUNG’S DISEASE
Management
Empty bowel with saline enema (30 to 50 ml)
daily
If can successfully decompress the bowel-
continue rectal washouts for 45 days
If unable to decompress the bowel- do Rt
transverse colostomy or Levelling colostomy
HIRSCHSPRUNG’S DISEASE
Colostomy
HIRSCHSPRUNG’S DISEASE
Swenson’s
Rectosigmoidectomy
Soave’s Transabdominal
Endorectal Pullthrough
HIRSCHSPRUNG’S DISEASE
HIRSCHSPRUNG’S DISEASE
Duhamel’s Retrorectal
Pullthrough
HIRSCHSPRUNG’S DISEASE
De La Torre’s Transanal
Endorectal Pullthrough
MECONIUM ILEUS
Uncomplicated cases show impacted meconium in
terminal ileum- inspissated tar like meconium
Accounts for 9 to 10% of all neonatal intestinal
obstructions
Present in 8 to 10% of cystic fibrosis patients at
birth
Complicated cases include volvulus,perforation
and peritonitis with sepsis
MECONIUM ILEUS
Signs depend on degree of obstruction and
complications
Significant abdominal distension may
develop during neonatal period
General status progressively deteriorates
with incipient sepsis in cases of perforation
In perforation, the scrotum or labia may have
greenish discoloration due to patent
processus vaginalis
MECONIUM ILEUS
MECONIUM ILEUS- Imaging Studies
Disparate sized bowel
loops
Soap bubble appearance-
Neuhauser’s sign
MECONIUM ILEUS- Management
60 to 70% of simple Meconium ileus can be
successfully treated with Gastrograffin enema
Other 30% need operative management
Goal of surgery is to remove the abnormal meconium
from GIT & maintain adequate length of bowel
Surgery consists of resection& anastomosis of involved
segment and/or roux-en-y ileostomy
MECONIUM ILEUS- Management
MECONIUM ILEUS- Management
Paul Mikulicz
Double Barrel
Ileostomy
Bishop-Koop’s
Distal chimney
Ileostomy
Santulli’s
Proximal
chimney
Ileostomy
MECONIUM PLUG
A long plug of mucus and sticky meconium in rectum
& distal colon results low intestinal obstruction
Due to immaturity of colonic & rectal expulsive
mechanism
Often associated with neonatal Hirschsprung’s
disease
Rectal exam/rectal wash results in expulsion of the
plug and relief of intestinal obstruction
MECONIUM PLUG
MECONIUM PERITONITIS
Intrauterine perforation of intestineleakage of
meconium into peritoneal cavity reaction of
peritoneum to this leaked meconium
Due to intrauterine vascular compromise of
intestine ischemia&perforation as early as 4th
month of intrauterine life
Different pathological typesMeconium pseudocyst,
generalised adhesive peritonitis,meconium ascites &
infected meconium peritonitis
MECONIUM PERITONITIS
Often associated with cystic fibrosis & Prognosis is poor
Bilious vomiting, failure to pass meconium and
abdominal distension
Abdominal wall edema, erythema and free fluid in
peritoneal cavity
AXR multiple air fluid levels and peritoneal
calcifications
Surgical treatment releasing of adhesions, removal of
devitalised tissues, closure of perforation, intestinal
resection& anastomosis
MECONIUM PERITONITIS
Meconium Ascites
Central bowel loops
Amorphous calcification
Multiple focal calcifications
Dilated bowel loops
Neonatal Bilious Vomiting - Algorithm
Neonatal Bilious Vomiting
Sl
N
o
History Physical Plain
XRay
Contrast
studies
Diagnosis Treatment
1
Bilious
vomiting
Not passed
meconium
Maternal
hydramnios
Upper
abdominal
distension
VGP
Down’s
syndrome
Double
Bubble
appearan
ce
Barium
meal :
Duodenal
obstructio
n
Duodenal
Atresia
Or
Annular
Pancreas
Kimura’s
Diamond
Shaped
Duodeno
duodenosto
my
2
Bilious
Vomiting
Infrequent
passage of
small amount
of meconium
Upper
abdominal
distension
Double
Bubble
Appearanc
e
Paucity of
gas in
distal
bowel
Barium
meal:
Absence of
C loop
Duodenum
Cork screw
appearanc
e
Malrotatio
n
Midgut
volvulus
Ladd’s
Procedure
Derotation
Resection
Anastomosi
s
Neonatal Bilious Vomiting
Sl
N
o
History Physical Plain
XRay
Contrast
studies
Diagnosis Treatment
3
Bilious
vomiting
Not passed
meconium
Abdominal
distension
Empty rectum
Triple
bubble
appearanc
e
Multiple air
fluid levels
Barium
enema :
Micro
colon
Jejunal
atresia
Or
Ileal
atresia
Resection&
End to
back
anastomosi
s
4
Bilious
Vomiting
Passing
meconium
Prematurity&
Birth asphyxia
Bleeding PR
Sick child
Septicemia
Abdominal
distension
Signs of
Peritonitis
Pneumato
sis
intestinalis
Portal
venous
gas
Free
peritoneal
gas
------------
Necrotisin
g
enterocoliti
s
Aggressive
medical
treatment
If it faills
Surgical
intervention
Neonatal Bilious Vomiting
Sl
N
o
History Physical Plain
XRay
Contrast
studies
Diagnosis Treatment
5
Delayed
passage of
meconium
Vomiting
Gross
abdominal
distension
P/R:Explosive
passage of
meconium &
flatus
Distended
bowel
loops
Barium
enema:
Swan neck
appearanc
e
Hirschspru
ng’s
disease
Pullthrough
operation
with or
without
colostomy
6
Bilious
Vomiting
Failure to
pass
meconium
Moderate to
severe
abdominal
distension
Disparate
sized
bowel
loops
Soap
bubble
appearanc
e
Barium
Enema:
Microcolon
Meconium
ileus
Gastrograffi
n enema
Resection
anastomosi
s
Bishop-
koop &
Santulli
Ileostomy
Neonatal Bilious Vomiting
Sl
N
o
History Physical Plain
XRay
Contrast
studies
Diagnosis Treatment
7
Bilious
vomiting
Failure to
pass
meconium
Moderate to
severe
abdominal
distension
P/R: Child
passes plug
Distended
bowel
loops --------------
Meconium
plug
syndrome
Rectal
washouts
8
Bilious
Vomiting
Failure to
pass
meconium
Severe
abdominal
distension
Abdominal
wall edema &
erythema
Multiple air
fluid levels
Peritoneal
calcificatio
n
Free
peritoneal
gas
Barium
Enema:
Microcolon
Meconium
peritonitis
Release pf
adhesions
Closure of
perforation
Resection
&
Anastomosi
s
TAKE HOME MESSAGE
“YELLOW COLOR VOMITUS IS THE
RED SIGNAL OF INTESTINAL
OBSTRUCTION UNLESS PROVED
OTHERWISE”
Neonatal Bilious Vomiting-  Part2

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Neonatal Bilious Vomiting- Part2

  • 1. NEONATAL BILIOUS VOMITING- Part 2 A PROBLEM ORIENTED APPROACH Dr.B.Selvaraj MS;Mch; FICS; Professor of Surgery Melaka Manipal Medical College Melaka 75150 Malaysia
  • 2. OBJECTIVES To discuss the differential diagnosis of biliary emesis in neonates To do appropriate workup to confirm the diagnosis To select the various treatment options To make you confident in managing a newborn with bilious vomiting
  • 3. Neonatal Bilious Vomiting-Causes Meconium Peritonitis Necrotising Enterocolitis Hirschsprung’s Disease Anorectal Malformation Rarely Mesentric Cyst & Intestinal Duplication Incarcerated inguinal hernia Duodenal atresia/stenosis Annular Pancreas Malrotation&MGV Intestinal Atresia: Jejunal&Ileal Meconium Ileus Meconium Plug
  • 4. Neonatal Bilious Vomiting-Causes •MALROTATION & MGV •MESENTRIC CYST& DUPLICATION CYST •CONGENITAL BANDS LIKE VI DUCT BANDS •MECONIUM ILEUS •MECONIUM PLUG •MECONIUM PERITONITIS EXTRINSIC •DUODENAL ATRESIA/STENOSIS •JEJUNAL/ILEAL ATRESIA •HIRSCHSPRUNG’S DISEASE •NECROTISING ENTEROCOLITIS CAUSES MURAL INTRA LUMINAL
  • 5. HIRSCHSPRUNG’S DISEASE Craniocaudal migration of ganglion cells of the bowel begins at 12th wk of gestation Arrest of this migration produces an aganglionic segment of bowel-absence of Aurbach’s & Meissener’s plexus This aganglionic segment of bowel unable to relax & peristaltic wave stops proximally- functional obstruction Incidence 1 in 5000 Male:Female 4:1
  • 6. HIRSCHSPRUNG’S DISEASE Mutations in RET proto-oncogene are commonly associated with Hirschsprung’s disease Not passed/ delayed passage of meconium Abdominal distension Bilious vomiting Fever & diarrhea suggest Toxic megacolon
  • 8. HIRSCHSPRUNG’S DISEASE Workup AXR: Dilated Bowel Loops Barium Enema: Swan Neck Appearance
  • 9. HIRSCHSPRUNG’S DISEASE Workup Absence of ganglion cells in myenteric plexus Suction rectal bx Noblet Rectal Mucosal Suction Biopsy Gun
  • 10. HIRSCHSPRUNG’S DISEASE Management Empty bowel with saline enema (30 to 50 ml) daily If can successfully decompress the bowel- continue rectal washouts for 45 days If unable to decompress the bowel- do Rt transverse colostomy or Levelling colostomy
  • 15. HIRSCHSPRUNG’S DISEASE De La Torre’s Transanal Endorectal Pullthrough
  • 16. MECONIUM ILEUS Uncomplicated cases show impacted meconium in terminal ileum- inspissated tar like meconium Accounts for 9 to 10% of all neonatal intestinal obstructions Present in 8 to 10% of cystic fibrosis patients at birth Complicated cases include volvulus,perforation and peritonitis with sepsis
  • 17. MECONIUM ILEUS Signs depend on degree of obstruction and complications Significant abdominal distension may develop during neonatal period General status progressively deteriorates with incipient sepsis in cases of perforation In perforation, the scrotum or labia may have greenish discoloration due to patent processus vaginalis
  • 19. MECONIUM ILEUS- Imaging Studies Disparate sized bowel loops Soap bubble appearance- Neuhauser’s sign
  • 20. MECONIUM ILEUS- Management 60 to 70% of simple Meconium ileus can be successfully treated with Gastrograffin enema Other 30% need operative management Goal of surgery is to remove the abnormal meconium from GIT & maintain adequate length of bowel Surgery consists of resection& anastomosis of involved segment and/or roux-en-y ileostomy
  • 22. MECONIUM ILEUS- Management Paul Mikulicz Double Barrel Ileostomy Bishop-Koop’s Distal chimney Ileostomy Santulli’s Proximal chimney Ileostomy
  • 23. MECONIUM PLUG A long plug of mucus and sticky meconium in rectum & distal colon results low intestinal obstruction Due to immaturity of colonic & rectal expulsive mechanism Often associated with neonatal Hirschsprung’s disease Rectal exam/rectal wash results in expulsion of the plug and relief of intestinal obstruction
  • 25. MECONIUM PERITONITIS Intrauterine perforation of intestineleakage of meconium into peritoneal cavity reaction of peritoneum to this leaked meconium Due to intrauterine vascular compromise of intestine ischemia&perforation as early as 4th month of intrauterine life Different pathological typesMeconium pseudocyst, generalised adhesive peritonitis,meconium ascites & infected meconium peritonitis
  • 26. MECONIUM PERITONITIS Often associated with cystic fibrosis & Prognosis is poor Bilious vomiting, failure to pass meconium and abdominal distension Abdominal wall edema, erythema and free fluid in peritoneal cavity AXR multiple air fluid levels and peritoneal calcifications Surgical treatment releasing of adhesions, removal of devitalised tissues, closure of perforation, intestinal resection& anastomosis
  • 27. MECONIUM PERITONITIS Meconium Ascites Central bowel loops Amorphous calcification Multiple focal calcifications Dilated bowel loops
  • 29. Neonatal Bilious Vomiting Sl N o History Physical Plain XRay Contrast studies Diagnosis Treatment 1 Bilious vomiting Not passed meconium Maternal hydramnios Upper abdominal distension VGP Down’s syndrome Double Bubble appearan ce Barium meal : Duodenal obstructio n Duodenal Atresia Or Annular Pancreas Kimura’s Diamond Shaped Duodeno duodenosto my 2 Bilious Vomiting Infrequent passage of small amount of meconium Upper abdominal distension Double Bubble Appearanc e Paucity of gas in distal bowel Barium meal: Absence of C loop Duodenum Cork screw appearanc e Malrotatio n Midgut volvulus Ladd’s Procedure Derotation Resection Anastomosi s
  • 30. Neonatal Bilious Vomiting Sl N o History Physical Plain XRay Contrast studies Diagnosis Treatment 3 Bilious vomiting Not passed meconium Abdominal distension Empty rectum Triple bubble appearanc e Multiple air fluid levels Barium enema : Micro colon Jejunal atresia Or Ileal atresia Resection& End to back anastomosi s 4 Bilious Vomiting Passing meconium Prematurity& Birth asphyxia Bleeding PR Sick child Septicemia Abdominal distension Signs of Peritonitis Pneumato sis intestinalis Portal venous gas Free peritoneal gas ------------ Necrotisin g enterocoliti s Aggressive medical treatment If it faills Surgical intervention
  • 31. Neonatal Bilious Vomiting Sl N o History Physical Plain XRay Contrast studies Diagnosis Treatment 5 Delayed passage of meconium Vomiting Gross abdominal distension P/R:Explosive passage of meconium & flatus Distended bowel loops Barium enema: Swan neck appearanc e Hirschspru ng’s disease Pullthrough operation with or without colostomy 6 Bilious Vomiting Failure to pass meconium Moderate to severe abdominal distension Disparate sized bowel loops Soap bubble appearanc e Barium Enema: Microcolon Meconium ileus Gastrograffi n enema Resection anastomosi s Bishop- koop & Santulli Ileostomy
  • 32. Neonatal Bilious Vomiting Sl N o History Physical Plain XRay Contrast studies Diagnosis Treatment 7 Bilious vomiting Failure to pass meconium Moderate to severe abdominal distension P/R: Child passes plug Distended bowel loops -------------- Meconium plug syndrome Rectal washouts 8 Bilious Vomiting Failure to pass meconium Severe abdominal distension Abdominal wall edema & erythema Multiple air fluid levels Peritoneal calcificatio n Free peritoneal gas Barium Enema: Microcolon Meconium peritonitis Release pf adhesions Closure of perforation Resection & Anastomosi s
  • 33. TAKE HOME MESSAGE “YELLOW COLOR VOMITUS IS THE RED SIGNAL OF INTESTINAL OBSTRUCTION UNLESS PROVED OTHERWISE”