neoplasia

1. Neoplasia

2. Chemical Carcinogenesis

3. Major Chemical carcinogens
1. Directly acting carcinogens
2. Procarcinogens that require metabolic
activation

4. Directly Acting Carcinogens
1. Alkylating agents
2. Acylating agents

5. Alkylating agents

6. Acylating agents

7. Procarcinogens

8. Polycyclic aromatic hydrocarbons

9. Natural plant products

10. Paraneoplastic syndromes

11. Small cell carcinoma
ACTH
ADH
ANP

12. Bronchogenic Carcinoma
Hypercalcemia
Myasthenia
Dermatomyositis
Venous thrombosis
Hypertrophic osteoarthropathy and
clubbing
Acanthosis nigrans

13. Pancreatic carcinoma
Cushing syndrome
Carcinoid syndrome
Venous thrombosis

14. Breast carcinoma
Hypercalcemia
Disorders of central and peripheral
nervous system
Dermatomyositis

15. Renal cell carcinoma
Hypercalcemia
Polycythemia

16. Gastric carcinoma
Carcinoid syndrome
Acanthosis nigrans

17. Hepatocellular carcinoma
Hypoglycemia
Polycythemia

18. Tumor antigens
1. Oncoproteins from mutated oncogenes
2. Protein products from tumor supressor genes
3. Over expressed cellular proteins
4. Abnormally expressed cellular proteins
5. Tumor antigens from viral oncoproteins
6. Tumor antigens from randomly mutated genes
7. Cell specific diffeentiation antigens
8. Oncofetal antigens
9. Abnormal cell surface molecules

19. Abnormally expressed cellular proteins
MAGE
GAGE
RAGE
BAGE