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  1. 1. Dr Hemanth S NaikMedical Research Scientist
  2. 2. INTRODUCTION• Acute intestinal infection caused by ingestion of food or water contaminated by a comma-shaped bacteria Vibrio cholerae• Deadly water borne disease• Untreated individuals may die from severe dehydration within two to three hours.
  3. 3. CAUSES• Vibrio Cholerae• Exposure from poor hygiene• Eating raw or undercooked food
  4. 4. Signs & Symptoms• Begin 1 to 3 days after infection• Abdominal cramps• Dehydration – Dry mouth – Dry skin – Excessive thirst – Sunken eyes – Low urine output – Low Blood Pressure• Watery diarrhea with a "fishy" odor• Tiredness & Unusual sleepiness
  5. 5. Sign & symptoms
  6. 6. DIAGNOSIS• Rectal swabs or from fresh stool samples.• Dark-field microscopic examination of fresh feces showing rapidly moving bacilli• All food isolates must be tested for the production of cholera enterotoxin.
  7. 7. TREATMENT• Water and electrolyte replacement therapy – “oral re- hydration salts”• Use of antibiotics
  8. 8. PREVENTION• Drink only boiled water• Avoid undercooked or raw food• Proper sanitation
  9. 9. HISTORY