Do cellular RNA molecules "strandedness" have any biological significance? 1) Yes, it gives RNA the ability to achieve tertiary structures. 2) Yes, RNA should be stable but DNA should be destroyed after it is used 3) Yes, RNA requires structural flexibility for various functions it may serve 4) Yes, RNA requires structural flexibility for various functions it may serve and it gives RNA the ability to achieve tertiary structures 5) No, it is most likely a random evolutionary process.