Growth hormons

1. GROWTH HORMONS
SAIYAD ARSH ZIA
M.PHARM
(PHARMACOLOGY)

2. GROWTH HARMONE:
 Growth hormone, also called somatotropic hormone or somatotropic, is a
protein molecule that contain 191 amino in a single chain and has a molecular
weight of 22,000.
 It causes growth of almost all tissue of the body that are capable of growing.
 It varies considerably in structure from species to species.
 Growth hormone does not function through a target gland but exerts its
directly on all tissue of the body.

4.  BENEFIT OF HUMAN GROWTH HORMONE:-
1. Reduce body fat
2. Regulate sleep
3. Protect vital calls
4. Improve quality of skin
5. Build some muscle
6. Improve immune system
7. Improve your memory & mood

5. 
SIDE EFFECTS OF HUMAN GROWTH HORMONE:-
1. Increased risk of diabetes
2. High blood pressur
3. Arthritis
4. Joint pain
5. Joint swelling
6. Headache
7. Nausea, Vomitiing

6. Factors that stimulate or inhibit secretion of growth Hormone:-
Stimulate growth hormone Inhibit Growth
Secretion hormone secretion
Decreased blood glucose Increased blood glucose
Decreased blood free fatty Increased blood free fatty
acids acids
starvation or fasting, protein Aging
deficiency. Obesity
Trauma, stress excitement Growth hormone inhibitory
Exercise hormone (somatostatin)
Testosterone estron deep sleep Growth hormone(exogenous)
Growth hormone- releasing Somatomedins(insulin-like
hormone growth factors)

8.  Mechanism of Action of Growth Hormones:-
i. Receptors for growth hormone are present on the plasma membrane of cells.
ii. Belong to cytokine family of receptors.
iii. Presence of excess of GH down regulates the synthesis of its receptors.
iv. Many hours must elapse after administration of GH before anabolic and growth-
promoting actions of the hormones to become evident.
v. Most of the actions of GH require the production of GH induced somatomedin C or
insulin-like growth factor (IGF).
vi. The plasma half-life of IGF is much longer than that of GH.

9.  Actions of the hormone can be broadly classified into two types:-
a. Indirect growth promoting action
b. Direct anti-insulin action.
1. Indirect growth promoting action
Indirect growth promoting action is due to the action of growth hormone on
liver. When the hormone acts on liver, liver secretes somatomedin C or
insulin-like growth factor (IGF- I). This substance acts on skeletal and
extraskeletal compartments.
 2. Direct anti-insulin action:-
This can be brought about in the target organs in presence of Cortisol
(permissive action of Cortisol is required.
i. On carbohydrate metabolism:-
It is a hyperglycemic agent. Increases the blood glucose level by:
a. Decreasing the peripheral utilization of glucose.
b. Increased gluconeogensis in liver.

12. THANK YOU
SAIYAD
ARSH ZIA