Which of the following would increase urine volume? 1) a diuretic drinking 2) large volume of water. 3) developing diabetes 4) overexpression of aquaporins Solution All listed factors can increase urine volume Diuretic agents causes diuresis, increase urine production. Large volume of water consumed leads to more urine formation Diabetes diseases symptoms includes frequent urination. Overexpression of aquaporins proteins respoponsible for water transfer can also increse urine volume.