PREPARED BY: MUHAMMAD ARIFF B. MAHDZUB BACHELOR MEDICINE AND SURGERY (MBBS) UNIVERSITY COLLEGE SHAHPUTRA, KUANTAN

1. 1
Acute inflammationPROBLEM BASED LEARNING (PBL)
PREPARED BY: MUHAMMAD ARIFF B. MAHDZUB
BACHELOR MEDICINE AND SURGERY (MBBS)
UNIVERSITY COLLEGE SHAHPUTRA, KUANTAN

2. ACUTE
INFLAMMATION

3. ACUTE INFLAMMATION
• The early stage of inflammation.
• Appearing within a few minutes or
hours.
• Characterize by :

4. 4

5. • This protects the injured areas from further
harm.
• It is immediately onset and the duration only
last long about few days.
• Without inflammation, wounds and
infections would never heal.

6. STIMULI
INFECTION
Bacteria/virus/
fungal/parasitic
TRAUMA
Thermal
injury/toxicity
TISSUE NECROSIS
ischemia
FOREIGN BODIES
Splinter/dirt/sting
IMMUNE REACTION
Hypersensitivity
reaction

7. MAJOR EVENTS
• VASCULAR CHANGES
Alterations in vessel caliber resulting in
increased blood flow (vasodilation) and
increased vascular permeability.
In addition, endothelial cells are activated,
resulting in increased adhesion of leukocytes
and migration of the leukocytes through the
vessel wall.

8. • CELLULAR EVENTS
Emigration of the leukocytes from the
circulation and accumulation in the focus of
injury (cellular recruitment),
Followed by activation of the leukocytes,
enabling them to eliminate the offending
agent.
 The principal leukocytes in acute
inflammation are neutrophils
(polymorphonuclear leukocytes).

9. OUTCOMES
• RESOLUTION
Complete restroration back to normal status.
Inflammatory measures such as
vasodilatation, chemical production, and
leukocyte infiltration cease, and damaged
parenchymal cells regenerate.

10. • ABSCESS FORMATION
A cavity is formed containing pus.
 It is a defensive reaction of the tissue to
prevent the spread of infectious materials to
other parts of the body.