DEFINE: gene enhancer and gene promoter (3-4 sentences each). Solution Answer : Enhancers : An enhancer is a segment of DNA that lies either upstream, within, or downstream of a structural gene that serves to increase transcription initiation from that gene. enhancers are found thousands of basepairs away from the genes. They interacts with the activators and coactivators which in turn recruits RNA polymerase to the site of transcription. Promoters are the specific sites on the DNA in which RNA polymerase enzyme binds and intiates the trancription/RNA synthesis process..