Is the measurement of the drug water solubility. Partitioning means that the drug will be divided in parts between water and oil layer. LogP is for hydrophilic or lipophilic. Lipophilicity tells about the compounds ability to dissolve into lipohilic (non-aqueous) solutions. Lipophilicity is needed for the compounds to permeate through the various biological membrane. Lipophilicity is typically measured as the compounds distribution between non-aqueous (octanol) and aqueous (water) phase and the result is expressed as a 10-base logarithm of the concentration ratios between these phases (partition coefficient), logP. P = [Co ]/[Cw] LogP = Log[Co ]/[Cw]. LogP > 2 lipophilic drug. LogP < 2 hydrophilic drug LogP only applied for neutral compound Low logP….. Low penetration to CNS High logP….. Low water solubility…. Not suitable for oral administration Solution Is the measurement of the drug water solubility. Partitioning means that the drug will be divided in parts between water and oil layer. LogP is for hydrophilic or lipophilic. Lipophilicity tells about the compounds ability to dissolve into lipohilic (non-aqueous) solutions. Lipophilicity is needed for the compounds to permeate through the various biological membrane. Lipophilicity is typically measured as the compounds distribution between non-aqueous (octanol) and aqueous (water) phase and the result is expressed as a 10-base logarithm of the concentration ratios between these phases (partition coefficient), logP. P = [Co ]/[Cw] LogP = Log[Co ]/[Cw]. LogP > 2 lipophilic drug. LogP < 2 hydrophilic drug LogP only applied for neutral compound Low logP….. Low penetration to CNS High logP….. Low water solubility…. Not suitable for oral administration.

1. Is the measurement of the drug water solubility.
Partitioning means that the drug will be divided in parts between water and oil layer.
LogP is for hydrophilic or lipophilic. Lipophilicity tells about the compounds ability to dissolve
into lipohilic (non-aqueous) solutions. Lipophilicity is needed for the compounds to permeate
through the various biological membrane. Lipophilicity is typically measured as the compounds
distribution between non-aqueous (octanol) and aqueous (water) phase and the result is
expressed as a 10-base logarithm of the concentration ratios between these phases (partition
coefficient), logP.
P = [Co ]/[Cw]
LogP = Log[Co ]/[Cw].
LogP > 2 lipophilic drug.
LogP < 2 hydrophilic drug
LogP only applied for neutral compound
Low logP….. Low penetration to CNS
High logP….. Low water solubility…. Not suitable for oral administration
Solution
Is the measurement of the drug water solubility.
Partitioning means that the drug will be divided in parts between water and oil layer.
LogP is for hydrophilic or lipophilic. Lipophilicity tells about the compounds ability to dissolve
into lipohilic (non-aqueous) solutions. Lipophilicity is needed for the compounds to permeate
through the various biological membrane. Lipophilicity is typically measured as the compounds
distribution between non-aqueous (octanol) and aqueous (water) phase and the result is
expressed as a 10-base logarithm of the concentration ratios between these phases (partition
coefficient), logP.
P = [Co ]/[Cw]
LogP = Log[Co ]/[Cw].
LogP > 2 lipophilic drug.
LogP < 2 hydrophilic drug
LogP only applied for neutral compound
Low logP….. Low penetration to CNS
High logP….. Low water solubility…. Not suitable for oral administration