Tuberculosis (TB) has been declared as a health emergency due to emergence of resistant strains of M. tuberculosis, multidrug resistant (MDR), extensively drug resistant (XDR) TB strains and totally drug resistant tuberculosis (TDR-TB) reported recently in some parts of the world. Therefore, the current situation necessitates developing new antitubercular agents acting on novel targets for effectively controlling TB. Thymidine Monophosphate Kinase (TMPKmt) enzyme is one such target, which is being explored. This review focuses on Structure Activity Relationship studies (SARs) and computational studies of various nucleotide and nucleoside derivatives of pyrimidine analogs reported as TMPKmt inhibitors.

1. Researchpaper of Dr. Trupti Chitre
Title: ExploringPyrimidinePharmacophoreasThymidineMonophosphate Kinase Inhibitorsfor
AntitubercularActivity:A Review
Authors: Trupti SameerChitre*,Kalyani DhirendraAsgaonkar,Shital Manoj Patil , Muthu
KumaradossKathiravanandSubhashBalkrishnaPadhye
Journal Details: CurrentTopicsin Medicinal Chemistry,2016, 16, 3211-3223
Publisher: BenthamScience Publishers
Description:
Tuberculosis(TB) hasbeen declaredasahealthemergencydue to emergence of resistant strains of
M. tuberculosis, multidrug resistant (MDR), extensively drug resistant (XDR) TB strains and totally
drug resistant tuberculosis (TDR-TB) reported recently in some parts of the world. Therefore, the
current situation necessitates developing new antitubercular agents acting on novel targets for
effectivelycontrollingTB.Thymidine Monophosphate Kinase (TMPKmt) enzyme is one such target,
which is being explored. This review focuses on Structure Activity Relationship studies (SARs) and
computational studies of various nucleotide and nucleoside derivatives of pyrimidine analogs
reported as TMPKmt inhibitors.
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