1
The Comprehensive Report on the Cannabis
Extract Movement and the Use of Cannabis
Extracts to Treat Diseases
Author: Jus...
2
Abstract
This report aims to be a comprehensive analysisofthe cannabis extract movement,a collectionof
patients,caregive...
3
1. Overview of Supporting Science
While there are noactual clinical studiesoncannabisextractmedicineforthe treatmentof d...
4
Guzmán in2008 found gliomacell invasionisinhibitedbyTHC throughthe down-regulationof matrix
metalloproteinase-2(http://c...
5
combinationwithachemotherapeuticagentagainst multiple myeloma
(http://www.ncbi.nlm.nih.gov/pubmed/24293211). CBD workedb...
6
Biological Chemistry showedthatanandamide inducedapoptosisinhumanneuroblastomaand
lymphomacells(http://www.jbc.org/conte...
7
A June 2010 studyin Pharmacology Biochemistry and Behavior elaboratedonveryintriguing
ideas,includingthe role of the ECS...
8
HIV is one of the mostdestructive virusesfacinghumanitytoday,andcannabismaybe the
solution. Patientshave continuouslyrep...
9
dosesof 10mg/kg and 100mg/kg significantlyreducedpercentage mortalityasaresultof seizures,but
all levelsof dosesdecrease...
10
neurotoxicityproducedbychemotherapy,specificallythe chemotherapeuticagentcisplatin
(http://www.ncbi.nlm.nih.gov/pmc/art...
11
had failedtocontrol the blastcountsand had devastatingside effectsthatultimatelyresulted inthe
deathof the patient,the ...
12
Thisconcludesthe study-level analysis,buthundredsof furtherstudiesandnewsarticlescanbe
foundat http://www.letfreedomgro...
13
231391971.html). Dr. Orrin Devinsky,Directorof the Comprehensive EpilepsyCenteratNew York
University,alsorecentlyreceiv...
14
2. History of Rick Simpson and Phoenix Tears
Giventhe multitude of referencestoRickSimpsonthroughoutthisreport,andhiscr...
15
methodwouldbypassthe needforsmoking. Hispleafailed,asthe doctorstill refusedtowrite a
prescription. Nonetheless,Rickdec...
16
Simpsonwasscheduledtoreturntocourt forsentencingonNovember30, 2007. However,while
awaitingsentencing,Simpsonwasarrested...
17
Thistrendof disregardanddisbelief forcannabisextractmedicinehasbeenaperpetuallystrong
presence. RickDwyer’sincidentwaso...
18
3. Individual Case Reports
Patientshave alwaysbeenthe central focusof the cannabisextract movement;real people whohave
...
19
Jameswasdiagnosedwithstomachcanceron May 18th
, 2005. Overthe subsequentfew months,
LeBlancenduredsurgery,chemotherapy,...
20
Insteadof examiningthe evidence,LegionCommandcame inandshutdownthe Maccan Branch. Rick
Dwyer’seffortstoshare the scient...
21
22
The above imagesare capturedfrom the documentary,whichalsoincludesfurtherimagesand
information.
A womannamedMaggie Pero...
23
A newsreportfeaturinganchorsEricSingerandHeatherSkoldof ABC NewsChannel 13discussedthe
use of cannabisoil forneckcancer...
24
2009, herconditiongreatlyimproved. The drastic,overwhelmingsuccesspromptedShonatowrite a
bookabout herexperience called...
25
fromthe jaw, to the waist. A compassionate strangerlearnedof herstoryand donated cannabisoil to
help. A litanyof improv...
26
A medicinal cannabisoil producernamedAamannDegarthhas observed amazingresultswithcannabis
oil,andhas documentedthe resu...
27
mind,andorgan damage. So manypatientshave stronglyinsisted thatcannabisoil isfarmore effective
than opiateswithnone of ...
28
The third personinthe film,Jeff,foundouthe hadfive tumorsonhisleftlung, diagnosedas
mesothelioma. Like Tom,Jeff foundou...
29
become Joe’scaregiver. Withinthree months of cannabisoil treatment,Joe felthistumorbeganto
shrink. By five months,he wa...
30
31
Denniswas stunnedtohearthisdiagnosis afterhavinglivedsucha healthylife,butgiventhatprostate
cancer wasprevalentinhis fa...
32
Dennisalsoappearedona programcalled“Spiral Up withAvaMarie” to tell hisstory
(http://www.youtube.com/watch?v=Q7ytJu4Zcr...
33
Denniscontinues totake amaintenance dose of cannabisoil andhasintegratedcancer-fightingfoods
intohisdietto ensure he st...
34
MykaylaComstock,a childpatient,hasattractedsignificantattentionrelatedtoherbattle withcancer.
In July 2012, Mykaylawas ...
35
As of February2014, Mykayla continuestodoverywell,andhasbeenincreasinglyfeaturedinthe
media. One suchinterview onVice.c...
36
failure andbrainfailure. Asthe documentarygraphically depicts,Cash’sstate wasmorbidlysevere,and
it isfranklystunninghow...
37
Giventhe potential forarecurrence,the Hydescontinuedtoprovide Cashwithcannabisoil afterthe
remissionnews. However,inMar...
38
In the November2013 issue of DOPE Magazine,the storyof SilasTedescowasdescribed
(http://issuu.com/dlistmagazine/docs/do...
39
Hi, My name's Corrie. I'm 55 years old. In May of 2007, I had a heart attack and subsequently had
a double bypass . As ...
40
sternum, as well as the nerve pain had become almost non existent. You have to understand, I had
resigned myself to a l...
41
my face, I hugged him mumbling, "thank you, thankyou." He looked at me, "No, Thank YOU!
You're the one that did this. Y...
42
Document 1
43
Document 2
44
Document 3
45
Anothernotable terminalcancersurvivorisJoanne Crowther,who directly providedthe authorof this
reportwithherfull storyan...
46
Joanne wasdiagnosedwithlarge B-celllymphomainsummer2009. The lymphomawaseliminatedwith
chemotherapyinFebruary2010. The ...
47
AnotherexamfromSeptember24th
,2012 statesJoanne isnow inremission. The reportalsonotesthat
she had beentakingregularhem...
48
49
Furtherdocumentationof Joanne’sfinal appointmentsis recordedbelow. There are afew key thingsto
note. Firstoff,there isa...
50
51
In late January,2014, Joanne appearedonCBC Newsspeakingaboutherstoryandthe new Canadian
medical marijuanaregulations (h...
52
A case close to the cannabispolicyreformmovementasa whole isthatof Michelle Aldrich. Michelle
has workedindrugpolicy re...
53
complicationsfromthe surgeryandhadto remaininthe hospital,butwasfinallydischargedMay31st
.
Michelle reportsthatina conv...
54
A videofeaturingClarkFrench,anactivist withNORMLUK, describeshow cannabis oil made amassive
difference to hismultiplesc...
55
althoughsmokingcannabisandsurgeryhelpedbriefly. Atone point,doctorssaidhe wouldn’tlastuntil
Christmas2011. He survivedw...
56
At the CannabisOil CuresCancerConcert,an event designed topromote the healingeffectsof oil,Amy
Jo Clarkrecountedherheal...
57
himto try cannabisoil. Afterthree anda half weeksof takinghomemade cannabisoileveryday,
producedbyhiswife Debra,Eliaswe...
58
A January2014 story ona Croationnewsstationdetailedthe storyof a38 yearoldman, referredtoas
Mark forconfidentiallyreaso...
59
Spencerisa youngchildwhowas diagnosedwithdiffusepilocyticastrocytomainFebruary2013, after
large tumorson the pineal gla...
60
As of May 27th
, 2014, Spenceriscontinuingtoimprove.
A particularlyhigh-profilecase ongoinginSouthAfricaisthatof Mario ...
61
A furtherarticle aboutthe cannabisextractsituationinSouthAfricaopenedwithaquote fromLindsey
Martin, a Cape Town motherw...
62
A personal lettersentfromapatienttothe blogMedical Marijuana411 detailstheirexperience of using
ShonaBanda’svaporizatio...
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
Comprehensive Report on The Cannabis Extract Movement
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Comprehensive Report on The Cannabis Extract Movement

  1. 1. 1 The Comprehensive Report on the Cannabis Extract Movement and the Use of Cannabis Extracts to Treat Diseases Author: Justin Kander Consulting Editor: Nicholas Davey 4th Edition June 2014 Originally Published October 2013
  2. 2. 2 Abstract This report aims to be a comprehensive analysisofthe cannabis extract movement,a collectionof patients,caregivers,doctors, dispensaries,corporations,and activists that advocate for the use of cannabis extract medicine to treat seriousdiseasessuchas cancers, heart disease,diabetes, rheumatoidarthritis, epilepsy, multiple sclerosis,Crohn’s,andotherdisorders. In aggregate, the movementhas demonstratedbeyondreasonable doubt that cannabis extracts can eliminate various typesof cancers in humans, and can control diseasesthat traditional pharmaceuticalsare ineffective against. The ultimate goal of this report issimple – to initiate immediate trialsof cannabis extract medicine inhospice centers. Patients insuch centers have terminal diagnosesand nothingto lose by attemptinga treatment whichhas a very real chance of curing them. Moreover,cannabis extracts are completelynon-toxicandcarry no physiological risks. If proven through hospice trials that cannabis extracts can reliablyeliminate cancers,true clinical trials can beginto determine optimumcannabis extract treatment regimentsand the full extentof cannabinoid medicine’seffectiveness. This report integratesthe latestscientificresearchand experiential resultstomake a compellingcase that cannabis extracts are effective treatmentsfora wide variety ofdiseases. The strength of the arguments, whenanalyzedas a whole,is overwhelming. The report progressesas follows: 1. Overview of Supporting Science 2. History of Rick Simpson and Phoenix Tears 3. Individual Case Reports 4. Corporate and Dispensary Operations 5. Doctor and Team Operations 6. Concluding Discussion
  3. 3. 3 1. Overview of Supporting Science While there are noactual clinical studiesoncannabisextractmedicineforthe treatmentof disease currentlyinexistence (althoughsome are scheduledtobeginsoon),there isanimmense bodyof scientificevidence demonstratingthatcannabinoidsare effectiveagainstvirtuallyanydisease. There is alsoa specificcase studyinthe journal CaseReportsin Oncology whichclearlydemonstratesthat cannabisextractscan eliminateleukemicblastcellsinahumanpatient. Most studies focusonthe effectsof individual cannabinoidsincellularandanimal models. Alone, these studies donotprove effectivenessinhumans.Inagreat manycases,cellularandanimal resultsdo not translate tohumansbecause of complex physiological differences. However,everycompoundthat worksfor humansstartsby workingat these smallerlevels. Furthermore,inthe contextof people actuallyusingconcentratedcannabinoidstoachieve curativeeffects,the scientificstudieshave farmore relevance. Substantial quantitiesof researchhave focusedoncannabinoidsandthe cellularmechanismsby whichtheyaffectvariouscancers. Suchmechanismsinclude inductionof apoptosis(programmedcell death),cell-cycle arrest, andinhibitionof angiogenesis(thegrowthof bloodvesselstotumors). However,severalstudieshave pointedoutthatotherprecise pathwaysare still undetermined, indicatingthe needtolearnmore abouthow cannabinoidswork. One of the firstpositive studieswascarriedoutatthe Medical College of Virginiain1974. The study,while intendedtoprove thatcannabisuse damagesthe immune system, actuallyfoundthat tetrahydrocannabinol slowedLewislungadenocarcinomaandleukemiagrowthina dose-dependent relationship(http://www.ncbi.nlm.nih.gov/pubmed?cmd=Retrieve&list_uids=1159836). The effectof THC on braincancer is well documentedbyDr.Manuel Guzmánand histeamof researchersinSpain. In1998, theypublishedastudydocumentingTHC’sabilitytoinduce apoptosisin gliomacells(http://www.ncbi.nlm.nih.gov/pubmed/9771884). In 2005, Guzmán’steam further identifiedthatTHCcoulddecrease productionof vascularendothelial growthfactorandmitigate activationof the relatedreceptorVEGFR-2,whichhelpedstopangiogenesis. Throughthismechanism, culturedgliomacellsandmouse gliomaswere reduced (http://cancerres.aacrjournals.org/content/64/16/5617.full). Additionally,one of Guzmán’sstudiesin 2003 showedactivationof cannabinoidreceptorswasassociatedwithapoptosisof skincancercells, while healthycellsremainedunaffected(http://www.jci.org/articles/view/16116). A 2006 Guzmánstudyon pancreaticcancer deliveredseveral interestingresults,mostnotably the observationsthatTHC inducedapoptosisinmultiple pancreaticcancercell linesandreducedtumor growthin twoanimal models(http://cancerres.aacrjournals.org/content/66/13/6748.full). Italsofound cancer cells expressedhigherlevelsof cannabinoidreceptorsthanhealthycells,possiblyindicatinga innate defensemechanismthe bodyhasagainstcancerouscells. Thatis,as a last resortagainstcancer, if the abnormal cellsthemselvespossessmore cannabinoidreceptors,theywouldbe more susceptible to the apoptosis-inducingeffectsof bothendoandphytocannabinoids. In thiscase,the role of the CB2 receptorwascritical,as blockingthe receptorpreventedTHC-inducedapoptosis;blockingthe synthesis of ceramide,aproapoptoticcompound,alsopreventedapoptoticeffects. A yetfurtherstudyby
  4. 4. 4 Guzmán in2008 found gliomacell invasionisinhibitedbyTHC throughthe down-regulationof matrix metalloproteinase-2(http://cancerres.aacrjournals.org/content/68/6/1945.full). THC is particularlyeffective againstlungcancerboth in vitro and in vivo. A 2007 Harvard study showedthatTHC inhibitednonsmall celllungcancercell linesandthatTHC-treated,cancerousmice had 50% reductionsintumorweightandvolume,and60% reductionsinmacroscopiclesions (http://www.aacrmeetingabstracts.org/cgi/content/meeting_abstract/2007/1_Annual_Meeting/4749). A laterApril 2012 studyfoundthat cannabidiol,anothercannabinoidprovingtobe evenmore beneficial than THC, alsohad an anti-metastaticeffectonone of the same lungcancer cell lines,A549,as well as the linesH358 and H460 (http://www.ncbi.nlm.nih.gov/pubmed/22198381). The effectonprostate cancer isalso well documented. A September1999 studyfoundthatTHC couldinduce apoptosisinthe cancerousPC3cell line,andthese effectsoccurredindependently of cannabinoidreceptors(http://www.ncbi.nlm.nih.gov/pubmed/10570948). The receptor-independent phenomenaisdiscussedfurtherbelow. Additionally,asummarizingstudyonthe endocannabinoid systemandprostate cancer discussedthe potential role of the systeminmaintainingprostate homeostasis,aswell asthe abilityof several cannabinoidstoreduce prostate cancercell proliferation and migration(http://www.ncbi.nlm.nih.gov/pubmed/21912423). Researchhasshownthat cannabinoidsexertpositive benefitsatthe geneticlevel. A studyby Dr. SeanMcAllisterinNovember2007 showedthatcannabidiol coulddown-regulate Id-1gene expressioninaggressivebreastcancercells,limitingtheirmetastaticpotential (http://mct.aacrjournals.org/content/6/11/2921.long). A furtherstudyinAugust2011 clarifiedthe pathwaysbywhichId-1 expressionwasinhibited(http://www.ncbi.nlm.nih.gov/pubmed/20859676). A September2004 studyfrom the Departmentof Medical OncologyinLondonshowedthatTHCwas a potentinducerof apoptosisinmultiple leukemiccell linesatleastpartiallythroughchanginggene expressionlevels(http://bloodjournal.hematologylibrary.org/content/105/3/1214.full). A 2012 studyinthe British Journalof Pharmacologyexaminedcannabidiol’ssuccessfulcapability to inhibittumorangiogenesis(http://www.ncbi.nlm.nih.gov/pubmed/22624859). A 2005 study demonstrated cannabidiolinhibitsgliomacell migration (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576089/). Moreover,itwas shownthatthese effects occurredindependentof cannabinoidreceptors,indicatingthatcannabinoidsinfluence physiological processesbeyondthe activationof receptors. Thissame cannabinoid-receptor-independentproperty was alsomentionedinthe 2004 Londonstudydiscussedabove,andina 2011 MolecularCancer Therapeuticsarticle aboutCBD inducingbreastcancercell death,the propertywasobservedyetagain (http://www.ncbi.nlm.nih.gov/pubmed/21566064). Pancreaticcancer,one of the mostfatal,isalso susceptibletothe apoptosis-inducingeffectsof cannabinoids (http://www.ncbi.nlm.nih.gov/pubmed/16500647). The previousstudy alsostates thatinsome cases, receptoractivationmayor may notbe critical toapoptosis-induction. AnotherstudyinFebruary2008 concludedthatcannabinoidsmaybe aneffective treatmentforinflammationandfibrosisinchronic pancreatitis(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2253501). An October2013 studyfoundthatCBD inhibitedcellproliferationof the U87-MG and T98G gliomacell linesanddecreasedexpressionof proteinsassociatedwithgrowth,invasion,and angiogenesis(http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0076918). A November2013 studyin InternationalJournalof Cancer testedthe effectsof CBDalone andin
  5. 5. 5 combinationwithachemotherapeuticagentagainst multiple myeloma (http://www.ncbi.nlm.nih.gov/pubmed/24293211). CBD workedbyitself orinsynergywithbortezomib to stronglyinhibitgrowth,arrestcell cycle progression,andinduce cell deathinmultiple myelomacells. A 2010 studyin Urology showedthatCBD inducedapoptosisoccurredviathe regulationof calciuminflux throughthe TRPV2channel protein,atrans-membrane channel inhumanurothelial carcinomacells(http://www.ncbi.nlm.nih.gov/pubmed/20546877). The November2011 issue of AnticancerResearch featuredanarticle aboutCBD and the syntheticcannabinoid WIN-55,212’sabilities to induce apoptosisinprostate andcoloncancercellsthroughthe modulationof complexcell signaling (http://www.ncbi.nlm.nih.gov/pubmed/22110202). Cannabinoidreceptorsingeneral were implicatedinimprovingdisease-free survival of liver cancer patients. A November2006 studyfoundthat disease-free survival wasmuchbetterinpatients withhighexpressionlevelsof CB1and CB2 receptorsthanthose withlow-level expression (http://www.ncbi.nlm.nih.gov/pubmed/17074588). In2005, a Swedishresearchteamfoundthat activatingreceptorswithsyntheticcannabinoidsandendocannabinoidscoulddecreasethe viabilityof mantle cell lymphoma(http://www.ncbi.nlm.nih.gov/pubmed/16337199). An article in2010 by a Chinese researchteamdiscussedthe effectsof cannabinoidreceptoractivationonhepatomacells,and foundactivationinducedapoptosisandinhibitedproliferation (http://www.ncbi.nlm.nih.gov/pubmed/20368112). AlthoughTHCand CBD have receivedthe bulkof attentionwhenitcomestoresearch, other cannabinoidsalsopossessanti-cancereffects. A September2006 article analyzedthe effectsof several cannabinoidsonhumanbreastcarcinoma. Cannabidiol wasfoundtobe the mostpotentinhibitorof cancer cell growth,whereascannabigerol (CBG) andcannabichromene (CBC) were foundtobe effective as well (http://jpet.aspetjournals.org/content/318/3/1375.full). AnOctober2013 article in Anticancer Research foundthat six cannabinoids,includingcannabidiol,cannabigerol,cannabigevarin,andtheir acid forms,couldinhibitleukemiacells independently (http://www.ncbi.nlm.nih.gov/pubmed/24123005). However,whenthe cannabinoidswere combined, the anticancereffectwasevengreater,indicatingasynergisticeffect. Endocannabinoids,the cannabinoid-likemoleculesproducedwithinthe body,have apoptosis- inducingeffectsaswell. A February2006 studyin ExperimentalCell Research foundthat the endogenouscannabinoidanandamide inhibitedthe adhesionandmigrationof breastcancercells,and that the endocannabinoidsystemregulatessuchcancercell proliferation (http://www.ncbi.nlm.nih.gov/pubmed/16343481). A June 2003 studyin Prostateshowedanandamide inducedapoptosisinmultipleprostate cancercell lines,includingthe PC3line,whichhasproven susceptibletoTHC as well (http://www.ncbi.nlm.nih.gov/pubmed/12746841). Evenmetastaticgrowth was inhibited. Additionally,the ceramide theoryof apoptosiswasbolsteredfurther,withthe study concludingthe cytotoxicactionsof anandamide mayoccurthroughthe inductionof intracellular ceramide production. Endocannabinoidswere alsoshowntoinhibitcolorectal cancercell proliferation ina January2008 study(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755791). An October2011 studydemonstratedthatanandamideandtwootherendocannabinoidscould reduce the viabilityof mice neuroblastomacells (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203169). Priorto this,a 2000 studyin The Journalof
  6. 6. 6 Biological Chemistry showedthatanandamide inducedapoptosisinhumanneuroblastomaand lymphomacells(http://www.jbc.org/content/275/41/31938.full). While there are farmore studiesoncannabinoidsandcancer,the above isa fairoverview. More antitumorstudieshave beenelegantlysummarizedandpresentedonthe National Cancer Institute’swebsiteat http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4. Before movingontostudiesregardingotherseriousdiseases,itisimportanttoexaminethe endocannabinoidsystem’s(ECS) organism-level functions. Ashasbeensuggestedthroughthe cancer- relatedstudiesalone,the importanceof the ECSis critical. All typesof cannabinoids –phyto,endo,and evensynthetic,caninduce apoptosisincancercellsthroughawide varietyof mechanisms. The factthat cancer cellsexpresshigherlevelsof cannabinoidreceptorsthannormal cellsisalsoremarkably intriguinginlightof endocannabinoidanticancerproperties. Evenwithoutphytocannabinoids,the body has an excellentdefense systemagainstabnormal cells. Whencellsbecome malignant,theydevelop more receptorsandbecome more susceptibleendocannabinoids,andthuscanbe efficientlyeliminated. However,itappearsthatdue to nutritional and/orenvironmental factors,the capabilitiesof endocannabinoidsare oftennotenough,andphytocannabinoidsupplementationisnecessarytorestore balance. Several studieshave pointedtothe homeostatic-maintenance propertiesof the ECS. Homeostasisisthe restingconditionof healthof anorganism, includingbutnotlimitedtofactorssuch as hydration,energy,temperature,andmaintenance of properenzyme,hormone,andneurotransmitter levels. Maintaininghomeostasisisof paramountimportance,forif itistoostronglyimpaired,an organismwill die. Researchisbeginningtoindicate thatthe ECSis the primaryregulatorof homeostasis inthe body. If thisis the case,thenthe astoundingmedicinalpropertiesof phytocannabinoidsbecome much more understandable. All diseaseultimately stemsfromanimbalance of some kind. Although thisstatementisanimmense simplificationof the complexoriginsandmechanismsof variousdiseases, it still accuratelydescribesthe fundamentalnature of disease –imbalance,irregularity,abnormality. Theoretically,phytocannabinoidsfunctioningwithinthe ECScouldrestore homeostaticbalance andthus eliminatebodilydisease. Giventhe factthatin practice humansare usingconcentrated phytocannabinoidstosuccessfullytreat amultitude of diseases, thesehigh-level theoriesonthe ECS mustbe givenmore weight. Asadditional researchisconducted,the exactmechanismsbywhich cannabinoidsheal individualdiseasesandmaintainorganism-wide homeostasiswilldoubtlessbe revealed. Dr. RobertMelamede, formerCEOand Presidentof CannabisScience andAssociate Professorat Universityof ColoradoColoradoSprings,haspioneeredsignificantresearchonthe ECS. Dr. Melamede’s paperon endocannabinoidsasglobal homeostaticregulatorsdiscussesthe remarkablydiverse methods of ECS function(http://necsi.edu/events/iccs6/viewpaper.php?id=70). Otherresearchhasconfirmed the regulatorypropertiesof the ECS. A January 2005 studydiscussedhow the ECSappearedearlyin evolutionandmodulatescritical functionslike the autonomicnervoussystem, immune systemand microcirculationin all vertebrates (http://alcalc.oxfordjournals.org/content/40/1/2.short). A 2006 study inInternationalJournalof Obesity spoke of the ECSas a regulatorof energyhomeostasis,participatingin functionslike fatmetabolismandappetite (http://www.nature.com/ijo/journal/v30/n1s/full/0803276a.html).
  7. 7. 7 A June 2010 studyin Pharmacology Biochemistry and Behavior elaboratedonveryintriguing ideas,includingthe role of the ECSin regulatingvariousaspectsof embryological developmentand homeostasis(http://www.sciencedirect.com/science/article/pii/S0091305710000924). The study primarilysuggestedthatthere were aspectsof the ECSwhichbecame dysfunctional inobese people. Since CB1 receptorswere knowntobe involvedinappetite,CB1antagonistdrugswere developedto blockthe activationof the receptorsandthus decrease appetite. While thiswaspartiallyeffective, numerousside effectsoccurredandthe use of such antagonistswasdiscontinued. Giventhe widespreadfunctionof cannabinoidreceptorsbeyondappetite,the verypoorresultsof CB1blockade are notsurprising. The studyconcludesbysayingalternativecannabinoid-basedtherapiesshouldbe openforconsideration. Furtherdiscussionof endocannabinoid systemregulatorymechanismsis examinedinDr.WilliamCourtney’ssegmentof the Doctor and Team Operations section. The ubiquitousnature of the endocannabinoidsystemisdemonstratedbythe fact that it is somehowinvolvedinagreat array of diseases. Althoughthe purposeof thisreportisnotto examine everyscientificarticle oncannabinoids,itisimportanttounderstandthe profoundlyversatile,positive, and diverse benefits of cannabinoids. A January2008 article in Neuropharmacologynotedhow CBD-treated,non-obese diabetes- prone female mice hadonlya32% incidence of diabetesdiagnosis,comparedto100% in the untreated group(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270485/). The studyalsoreferencedanearlier workwhere cannabidiol loweredthe incidence of diabetesinmice. A June 2007 studyproposedthat the ECS regulatesglucose homeostasisthroughcoordinatedactionsof CB1and CB2 receptors, whilealso showingactivationof CB2receptorsimprovedglucose tolerance (http://www.sciencedirect.com/science/article/pii/S001429990700249X). Intriguingly,the study showedactivatingCB2receptorsresultsinsimilaractionsasblockingCB1receptors,demonstratingthe integral relationshipbetweenbothreceptortypes. A 2010 studyinthe Journalof theAmerican College of Cardiology,partiallyauthoredbyDr. Raphael Mechoulam(the firsttoisolate tetrahydrocannabinol),concludedthatcannabidiol mayhave great therapeuticpotential fordiabetes,throughthe attenuationof oxidative/nitrative stress, inflammation,cell death,andfibrosis(http://www.natap.org/2010/newsUpdates/marijuana.pdf). Benefitforcardiovasculardisorderswasalsosuggested. Infact,a previous2002 studyin Bulletin of ExperimentalBiology and Medicine linkedthe activationof cannabinoidreceptorswithcardioprotective effects,demonstratingthatcannabinoidscanpreventthe deathof healthycellsduringaheartattack (http://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=Retrieve&list_uids=12428278). Also,a March 2006 studyfoundthat the ECS, throughactivationof CB2 receptors,wasimportantforprotection frommyocardial ischemia,aconditionresultingindecreasedbloodflow tothe heart (http://www.ncbi.nlm.nih.gov/pubmed/16618028). Cannabinoidsalsoexertsignificantliverprotectiveeffects. A December2003 studyin Molecular Pharmacology showedthatasyntheticcannabinoidcouldinhibitinflammatoryliverdamage inmice, partiallythroughpromotingthe earlyexpressionof protective genes (http://molpharm.aspetjournals.org/content/64/6/1334.full). A later2008 studyin the same journal concludedthatTHC couldinhibithepatitisinmice byreducinglivertissue injury (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828293/). The studyalsofoundTHC suppressed inflammationandsignificantlyincreasedspecializedliverregulatorycells.
  8. 8. 8 HIV is one of the mostdestructive virusesfacinghumanitytoday,andcannabismaybe the solution. Patientshave continuouslyreported thatcannabisuse improvessymptoms,including appetite,muscle pain,nausea,anxiety,nerve pain,anddepression (http://www.ncbi.nlm.nih.gov/pubmed/15857739). Evidence alsosuggeststhatcannabinoidscan inhibitthe HIV virusdirectly. Much insightcomesfromresearchintosimianimmunodeficiencyvirus (SIV),the primate formof HIV. AnApril 2010 studyfoundthatchronic THC treatmentresultedinlower plasmaviral load,lowerlymphnode proviral DNA,andlowerviral gagRNA,irrespective of disease stage (http://www.fasebj.org/cgi/content/meeting_abstract/24/1_MeetingAbstracts/752.6). A June 2011 studyinAIDS Research and Retroviruses confirmedmanyof these results,showingthatchronicTHC administrationdecreasedearlymortalityfromSIV infectioninrhesusmacaques,withanassociated decrease inplasmaandCSF viral loads(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131805/). The studyalsoanalyzed THC in vitro,findingthe compound decreasedSIV viral replicationinMT4-R5 cells. A December2011 studyin Journalof NeuroimmunePharmacology revealedTHCandanothercannabinoid knownas CP55940 couldreduce the migrationof microglial-like cellstowardsthe proteinTat. Thisis significantbecauseTatisimplicatedinHIV neuropathogenesis; thus, inhibitingTatcan potentiallyhelp control HIV (http://www.ncbi.nlm.nih.gov/pubmed/21735070). Anothersignificantstudy carriedoutby the Mount Sinai School of Medicine andpublishedMarch2012 demonstratedthatactivatingCB2 receptors,butnotCB1 receptors,“reducedinfectionof primaryCD4+T cellsfollowingcell-free andcell- to-cell transmissionof CXCR4-tropicvirus” (http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033961). The report concludedthatCB2 agonistsmay be beneficial fortheirantiviral effectsagainstCXCR4-tropicvirusesin late HIV-1infectionstages. The role of cannabinoidsfortreatmentof epilepticconditionshasbeengainingpopularity recently,andseveral veryprominenttreatmentcasesare discussedinthe case sections. A 1981 study in the Journalof Clinical Pharmacology suggestedthatcannabidiolcouldbe therapeuticallyeffective againstthree of the four majortypesof epilepsy,includinggrandmal,cortical focal,andcomplex partial seizures(http://www.ncbi.nlm.nih.gov/pubmed/6975285). A September2003 studyin JPET useda rat pilocarpine model of epilepsytotestthe effectivenessof THCand anothercannabimimeticonseizures – treatment“completelyabolishedspontaneousepilepticseizures” (http://jpet.aspetjournals.org/content/307/1/129.full). The studyalsotestedaCB1 antagonist,and foundusingitto blockCB1 receptorssignificantlyincreasedseizure duration. Anotherobservationwas that an endogenouscannabinoidknownas 2-arachidonylglycerol significantlyincreasedduringseizures, suggestingthatendocannabinoidsalongwithphytocannabinoidsmodulate seizure activitythroughCB1 activation. A verycomprehensive June2012 studyin Seizure describedthe effectsof cannabidiol onthree modelsof seizures(http://www.ncbi.nlm.nih.gov/pubmed/22520455). A previousstudybythe same teamshowedthatcannabidiol reducedseizureseverityandlethalityin the in vivo model of pentylenetetrazole-inducedgeneralisedseizures. Inthisstudy,the acute pilocarbine model of temporal lobe seizure andthe penicillinmodel of partial seizure were examinedthroughCBDadministrationto rodentsat levelsof 1,10, and100mg/kg. In the pilocarbine model,all levelsof CBDdosessignificantly reducedthe numberof animalsexperiencingthe mostsevere seizures. Inthe penicillinmodel,CBD
  9. 9. 9 dosesof 10mg/kg and 100mg/kg significantlyreducedpercentage mortalityasaresultof seizures,but all levelsof dosesdecreasedthe numberof animalsexperiencingthe mostsevere tonic-clonicseizures. Inflammationisatthe core of manydiseases,andmanystudiesimplicate cannabinoidsin controllingexcessive inflammation. Dr.Raphael Mechoulam, amongothers,holdsapatentonthe use of cannabidiol totreatinflammatorydiseases. The diseaseslistedinthe patentincluderheumatoid arthritis,multiple sclerosis,ulcerative colitis,andCrohn’sdisease (http://www.patentstorm.us/patents/6410588/fulltext.html). A detailedstudyinthe Journalof Clinical Investigation alsodescribedthe abilityof the ECSto mediate protectivesignalsthatreduce inflammation(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC385396/). Anotherstudypointedtothe abilityof cannabinoidstomodulateinflammatoryanddegenerativeneuronal damage inmultiple sclerosis,alsoindicatingthatthe ECSis dysregulatedinthe disease (http://brain.oxfordjournals.org/content/130/10/2543.full). The resultspointtothe needforexternally regulatingthe ECSto achieve effective MStreatment. Furthermore,aJuly2003 study foundthat cannabinoidsinhibitedneurodegenerationandprovidedneuroprotectionfrominflammatorydiseases (http://brain.oxfordjournals.org/content/126/10/2191.full). Furthermore,apatentexistsonTHCfor treatingandpreventingsymptomsof MS (http://www.patentstorm.us/applications/20060167084/fulltext.html). A summarizingstudyinthe Journalof the NeurologicalSciences hypothesizedthatthe ECScan provide neuroprotectioninCNS inflammatorydiseases(http://www.ncbi.nlm.nih.gov/pubmed/15894331). Chronicpainis a symptomof manydiseasesanda conditioninitself. Painisthe ultimate driver of desperationandthe sensationthatdestroysall happinessinlife. Itleadspeople todepressionand suicide. Currentmethodsfordealingwith painrelyalmostentirelyonopiates,addictive narcoticsthat cannot provide long-termreliefandresultinahost of terrible side effects,suchasconstipation,mental disconnection,andwithdrawal. The scientificandexperiential evidence suggest thatcannabinoidsare the besttreatmentforpain. A February2003 studystatedCB2 activationinhibitsacute,inflammatory,andneuropathicpain responses(http://www.ncbi.nlm.nih.gov/pubmed/12550743). Later that year,a studyin Anesthesiology referredtocannabinoidreceptoragonists’abilitiestoinhibitinflammatoryhyperalgesia,anincreased sensitivitytopain (http://journals.lww.com/anesthesiology/Fulltext/2003/10000/Inhibition_of_Inflammatory_Hyperalgesi a_by%20.31.aspx). A July2006 studyin CurrentNeuropharmacology demonstratedthatactivationof cannabinoidreceptorsmodulatedpainthresholds,reducedinflammation,andevenworked synergisticallywiththe endogenousopioidsystem (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430692/). An earlier1999 studylinkedanandamide withpainmodulation(http://www.pnas.org/content/96/21/12198.full). In2010, a Public Library of Science article postulatedcannabinoiduse asatreatmentformanagingpostoperativepain,andstated that endocannabinoidsinhibitednociceptive painprocessingthroughactivationof bothCB1 andCB2 (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878341/). A 2006 studyin CurrentMedicalResearch and Opinion testedTHCtreatmentonfibromyalgiapatientswheresignificantreductionof painwas observed,althoughseveralpatientswithdrew fromthe studydue toadverse side effects,mostlikely psychoactive innature (http://www.ncbi.nlm.nih.gov/pubmed/16834825). A May 2012 studyin The Journalof Neurosciencedemonstrated thatthe CB1 receptorwasassociatedwithbothreducedpainand
  10. 10. 10 neurotoxicityproducedbychemotherapy,specificallythe chemotherapeuticagentcisplatin (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366638/). A fantasticsummaryof cannabinoidpain-reductioneffectsisdetailedinthe June 2003 issue of Journalof Pain and SymptomManagement,viaalettertothe editor (http://www.jpsmjournal.com/article/S0885-3924(03)00142-8/fulltext). The overview statesthat, “Cannabinoidsblockpainresponsesinvirtuallyeverylaboratorypainmodel tested.Inmodelsof acute or physiological pain,cannabinoidsare highlyeffective againstthermal,mechanical,andchemical pain, and are comparable toopioidsinpotencyandefficacy.Inmodelsof chronicpain,cannabinoidsexhibit efficacyinthe modulationof bothinflammatory andneuropathicpain.” The article alsodescribesthree caseswhere mere smokedcannabiswasable toreduce heavyopiate use byconsiderable amounts. Giventhatsmokedcannabis delivers cannabinoids inahighlyinefficientmanner,itisastoundingthat smokingstill worksmore effectivelythanpharmaceutical-grade opiates. The most powerful pieceof scientificevidence demonstratinganticancereffectsof cannabis extractsinhumans is a November2013 article in Case Reportsin Oncology (http://www.karger.com/Article/FullText/356446). The article describedthe case of a 14-year old female withterminal acute lymphoblasticleukemiawithaPhiladelphiachromosome mutation. This formof leukemiaismuchmore aggressive thanothertypes. 34 monthsof chemotherapyandradiation failedtostopthe cancer, and the patientwasplacedinpalliative home care. The familydecidedtouse cannabisoil as a lastresort afterconductingresearchindicating potential effectiveness. The firstdose of extractwasgivenonFebruary21st , 2009. Priorto this,from February4th to the 20th , the patient’sleukemicblastcell countrose from51,490 to 194,000. Even afterbeginningthe oil,the count continuedtorise,peakingat374,000 onFebruary25th . However,there wassubsequentlyasharp decrease inblastcount,whichcorrelatedwithanincrease indose. ByDay 39, the blastcount had decreasedto300. The total treatmentlasted78 days,at whichpointthe leukemicblastcellswere almostcompletelygone. Unfortunately,the patientpassedawaydue toa bowel perforation,which apparentlywas causedbythe side effectsof the priorintense chemotherapyregiment. The study concluded, “The resultsshownhere cannotbe attributedtothe phenomenonof ‘spontaneousremission' because a dose response curve wasachieved.Three factors,namelyfrequencyof dosing,amountgiven (therapeuticdosing) andthe potencyof the cannabisstrains,were critical indeterminingresponse and disease control.Byviewingfigure 6,itcan be seenthatintroducingstrainsthatwere lesspotent,dosing at intervals>8 h and suboptimal therapeuticdosingconsistentlyshowedincreasesinthe leukemicblast cell count.It couldnot be determinedwhichcannabinoidprofilesconstituteda‘potent'cannabisstrain because the resinwasnotanalyzed.Researchisneededtodeterminethe profile andratiosof cannabinoidswithinthe strainsthatexhibitantileukemicproperties. These resultscannotbe explainedbyanyother therapies,asthe childwasunderpalliativecare and wassolelyoncannabinoidtreatmentwhenthe response wasdocumentedbythe SickKidsHospital. The toxicologyreportsruledoutchemotherapeuticagents,andonlyshowedhertobe positive forTHC (tetrahydrocannabinol) whenshe had‘arecentmassive decrease of WBCfrom350,000 to 0.3' inducing tumor lysissyndrome,asreportedbythe primaryhematologist/oncologistatthe SickKidsHospital. Thistherapyhas to be viewedaspolytherapy,asmanycannabinoidswithinthe resinousextract have demonstratedtargeted,antiproliferative,proapoptoticandantiangiogenicproperties.Thisalso needstobe exploredfurther,asthere ispotential thatcannabinoidsmightshow selectivitywhen attackingcancer cells,therebyreducingthe widespreadcytotoxiceffectsof conventional chemotherapeuticagents.Itmustbe notedthatwhere ourmost advancedchemotherapeuticagents
  11. 11. 11 had failedtocontrol the blastcountsand had devastatingside effectsthatultimatelyresulted inthe deathof the patient,the cannabinoidtherapyhadnotoxicside effectsandonlypsychosomatic properties,withanincrease inthe patient'svitality.” (Note:HempOil referstoTHC-richcannabis-derivedextract,nothempseedoil) Reportsof successwithcannabisstretchback to the post-Civil Warera. The March 1868- February1869 issue of TheMedical Record recordsseveral casesof physiciansusingcannabisextractsin theirpractice (http://books.google.ca/books?id=8DVYAAAAMAAJ&printsec=frontcover). Twocasesare attachedbelow.
  12. 12. 12 Thisconcludesthe study-level analysis,buthundredsof furtherstudiesandnewsarticlescanbe foundat http://www.letfreedomgrow.com/cmu/Grannys%20List%20January%202013.pdf. The listof studies,collectedbyanactivistknownasGranny StormCrow,features research showingthe effectivenessof cannabinoidsfornearlyanydisease imaginable. Inadditiontothe diseasesdiscussed above,the listcontainsstudiesrelatingtoADD/ADHD,addiction,depression,Parkinson’s,and osteoporosis. Effectsonless well knowndiseasesare alsodocumented,likeMeige’ssyndrome and Niemann-Pickdisease. Cannabisisfurther useful forconditionswe donotthinkof as serious,suchas the hiccups. Much is lefttobe learnedaboutthe endocannabinoidsystemandits complex interactions with phytocannabinoids. The exactmechanismsof ECSfunction,anddysfunction, are still notentirely understood. Despitethe vastmysteriouslandscape ahead,manyconcrete observationscanbe gleaned fromthe existingresearch,whichthankfullyisstillquite robust. First,bothendocannabinoidsand phytocannabinoids exerttherapeuticeffectsforvirtuallyanydisease. Evensyntheticcannabinoidshave beenshowntoinduce benefitthroughactivationof cannabinoidreceptors. The ECShas been implicatedinmaintaininghomeostasisthrougha manybodysystems; thishomeostaticregulatory propertywouldexplain whycannabinoidsare effective againstsomanydifferentconditions. When examinedapartfromexperientialdata,thisresearchissimplypromising,andnomore. However,given that humansare actuallyusingconcentratedcannabinoidstoachieve cure-levelresultsforconditions where curative powers are potentiallyimplied,thisresearchmustbe takenfarmore seriously. Infact, evenif thisresearchdidn’texist,the magnitudeof the experiential dataisimpossible toignore. Current scientificstudiesgrantlegitimatecredibilityandilluminate cellularmechanismsbywhichthese curative resultsare occurring. In the future,more researchwill reveal notonly more abouthow the ECS functions,butthe beststrains,dosages,andconstituentsforcannabisextractmedicine. Forexample, differentratiosof THC/CBDmay be betterfor differentconditions;likewise,the ideal use of sativa, indica,or hybridstrainsmustalsobe examined,alongwiththe potential rolesof juicingandothernew administrationmethods. Researchersanddoctorsaroundthe countryare movingquicklytoembrace the inevitable future of cannabismedicine. Inlate September2013, GW Pharmaceuticalsannouncedthe startof clinical trialsof a newcannabistreatmentforepilepsy (http://www.leafscience.com/2013/09/20/around-world-researchers-begin-clinical-trials-cannabis- epilepsy/). InNovember2013, theyannouncedthe commencementof trialsforrecurrentglioblastoma multiforme, atype of braincancer (http://www.prnewswire.com/news-releases/gw-pharmaceuticals- commences-phase-1b2a-clinical-trial-for-the-treatment-of-glioblastoma-multiforme-gbm-
  13. 13. 13 231391971.html). Dr. Orrin Devinsky,Directorof the Comprehensive EpilepsyCenteratNew York University,alsorecentlyreceivedFDA approval fora clinical trial of CBDfor childrenwithepilepsy. A recentstudyinSpain,fundedbythe SpanishMinistryof Science andInnovationandComplutense University,resultedinthe developmentof amicroparticle deliverysystemforTHC (http://www.leafscience.com/2013/09/07/cancer-researchers-develop-micro-delivery-system-for-thc/). Usingsuch a deliverysystemwasshowntobe betteratinhibitingcancercell growththanTHC alone,as the microparticlesallow forbetterabsorptionandsustainedrelease. Dr.SeanMcAllister,ascientist mentionedabove whohasconductedresearchonCBDand breastcancer,is seekingtoinitiateFDA- approvedtrialsforCBD and cancer inhumans(http://www.leafscience.com/2013/11/08/cancer- researchers-verge-human-trials-cannabis/). A December11th , 2013 pressrelease fromGWPharmaceuticalsannouncedaUSPatent Allowance forthe use of cannabinoidsintreatingglioma (http://www.gwpharm.com/GW%20Pharmaceuticals%20plc%20Announces%20US%20Patent%20Allowa nce%20for%20Use%20of%20Cannabinoids%20in%20Treating%20Glioma.aspx). Itisimportantto point out thispatentrelatestothe treatmentof cancer,not side effectsof chemotherapy. “The subjectpatentspecificallycoversamethodfortreatinggliomainahumanusinga combinationof cannabidiol (CBD) andtetrahydrocannabinol (THC) whereinthe cannabinoidsare ina ratioof from1:1 to1:20 (THC:CBD) withthe intenttoreduce cell viability,inhibitcell growthorreduce tumor volume.” An earlierpatentfiledonMarch 11, 2011, coversthe general applicationof phytocannabinoids inthe treatmentof cancer(http://www.google.com/patents/US20130059018). As more researchisconductedintocannabinoidmedicine,furtherinnovationsandusesare boundto be discovered. Fornow,the scientificevidence stronglysupports every anecdotal claim. Thispaper’scoverpicture comesfromthe followingscientific article - http://www.cell.com/trends/pharmacological-sciences/abstract/S0165-6147(09)00128-X.
  14. 14. 14 2. History of Rick Simpson and Phoenix Tears Giventhe multitude of referencestoRickSimpsonthroughoutthisreport,andhiscritical importance tothe beginningof the moderncannabisextractmovement,hishistoryisdescribedindetail below. RickSimpsonwasborninSpringhill,NovaScotiaonNovember30,1949. He beganworkat the age of 16, and transitionedtoacareerin powerengineeringat18. Rickworkedas an engineeruntil 1997, whenhe sufferedawork-relatedinjuryandwasdiagnosedwithpost-concussionsyndrome. He was prescribedanumberof drugsto alleviate hiscondition,butnone were effective. In late 1998, Rick watchedan episode of “The Nature of Things”,inwhichDr.David Suzuki interviewedmedical marijuanapatientswhohadachievedastoundingresultswithcannabis. This promptedRickto try itfor himself. He quicklynoticedthatsmoking cannabisdidmore forhiscondition than anyof the pillshe wastaking. Despite the effectivenessof hisself-administeredmedication,Rick’s doctor wouldnotprovide alegal prescriptionforcannabis,statingthe herbwas“badfor the lungs”. In response,Rickaskedif itwouldbe bettertoextractthe essential oilsfromcannabis,knowingsucha
  15. 15. 15 methodwouldbypassthe needforsmoking. Hispleafailed,asthe doctorstill refusedtowrite a prescription. Nonetheless,Rickdecidedtopursue thiscourse anyway,andthroughtrial-and-error developedanacceptable methodforproducingcannabisoil. Until 2001, Rickcontinuedtakingprescriptionmedicinesuntilhisdoctortoldhimthere was nothingmore theycoulddo. Rick thenceaseduse of pharmaceuticals,leavingcannabisoil ashisonly medication. Thiscourse greatlyimprovedhiscondition. In late 2002, Rick wasdiagnosedwithskincancer,whichwaspresentonthree partsof his body; twopatcheson hisface andone on hischest. InJanuary 2003, Rick had one areaof skincancer removedsurgically,withthe remainingtwopartsscheduledtobe removedlater. Shortlyafterthe surgery,Rickrecalledaradioshowhe’dheardabout the 1974 Universityof Virginiastudyindicating tetrahydrocannabinol inhibitedcancergrowth (http://www.ncbi.nlm.nih.gov/pubmed?cmd=Retrieve&list_uids=1159836). Rick knew cannabisoil containedconcentratedTHC,sohe decidedtophysicallytestitonhimself. He appliedhomemadeoil to bandagesandplacedthemdirectlyonthe skincancersites. In fourdays,the cancers were gone. Excited,Rickwentbackto hisdoctor’soffice toinformthemthat he had curedhimself withcannabisoil, but the reactionsfromboththe receptionistanddoctorwere negative. Afterhisincrediblepersonalexperiences,Rickdecidedhe wantedtohelpothers. He began growingcannabisinmassive quantitiesinhisbackyard,usingittoproduce thousandsof gramsof oil, whichhe gave away forfree to anyone inneed. He quicklyobservedthatcannabisoil exertedpanacea- like effects. Iteliminatedanytype of cancerhe came across andreversednearlyanytype of medical condition. Diabetes,chronicpain,multiple sclerosis,nerve damage,inflammatoryandautoimmune disorders,andmental conditionsbecame completelycontrolledordisappeared. Mostpatientscame to Rick as a lastresort,not believingsomethingassimple ascannabisoil couldreallywork. The standard treatmentprovidedwas60 gramsto be usedover90 days;thiswas the dosinglevel Rickobservedwas necessarytoachieve curative effects. However,as massingevidenceindicates,sometimesmuchlessor much more cannabis oil isneededtorealize sucheffects. Rick’sactivitiesattractedbothmediaandlaw enforcementattention. Inlate 2006, storiesabout Rick appearedonGlobal National NewsandGlobal MaritimesEveningNews,twopopularCanadian newsprograms. Priorto that, onAugust3rd , 2005, the Royal CanadianMountedPolice (RCMP) raided Rick’shome,andconfiscated1,190 cannabisplants (http://www.cumberlandnewsnow.com/Justice/2007-09-13/article-370849/Seized-marijuana-plants- had-value-up-to-830000-RCMP/1). Althoughthe citedarticle states1,190,Rick saidthe plantcount was actually1,620; one of the newsreportsalsomentionsacountnumberaround1,600. The raid ledto a trial in September2007, where Rickfacedchargesincludingpossessionof lessthan30 gramsof cannabis,possessionof lessthanthree kilogramsof tetrahydrocannabinolforthe purpose of trafficking, and unlawful productionof cannabis. He wasfoundguiltyonall charges. Whendiscussingan adjournmentforsentencing,Ricksaidthe followingtoJudge FelixCacchione: “It may be betterto lockme up rightnow.As soonas I get home I’mgoingto treatmy patients.I’m goingto growthat plantuntil the day I die,soI mightas well be putinjail today.I can’t stopinthe middle of [treatment].People’slivesare atstake here.” (http://www.cumberlandnewsnow.com/Justice/2007-09-19/article-381209/Simpson-guilty/1).
  16. 16. 16 Simpsonwasscheduledtoreturntocourt forsentencingonNovember30, 2007. However,while awaitingsentencing,SimpsonwasarrestedagainfortraffickingTHC,and wasremandedforfourdays until beingreleased. WhenSimpsonwassentencedforhisfirstcharges,he receiveda$2,000 fine, prohibitiononownershipof firearms(asisthe case withmostdrug charges),andone day custody, deemedservedbyhiscourtappearance. Judge Cacchione explainedhisdecision,saying,“Mr.Simpson has a sincere belief he hasa cure withthisoil and shouldbe commended,butinreality,he broke the law”(http://www.cumberlandnewsnow.com/Justice/2008-02-11/article-382416/Simpson-considers- leaving-country/1). Inearly2008, Rickreturnedto court to face the charge relatedtohis secondarrest, and wassentencedtoeightdaysincustodyby Judge Carole Beaton. Aswiththe firstcase,the custody time wasdeemedservedbyRick’spreviousremandtime. “Mr. Simpsonisinan unusual position,because unlike otherpeople engagedinthe drugtrade, he was not engagedintraffickingforfinancial gain,"saidJudge CaroleBeaton."He wasengagedinan altruisticactivityandwasfirminhisbelief thathe washelpingothers”(http://www.salem- news.com/articles/december052009/rick_simpson_bk.php). Withtwo separate legal incidentshappeningonlymonthsapart,Rickwasforcedto cease his activitiesforsome time. InNovember2009, Rick wenttoAmsterdamto receive the HighTimes FreedomFighterof the YearAward(http://www.hightimes.com/read/rick-simpson-seeks-political- refuge-europe). While inEurope,Rick’shome was raidedagainbypolice,resultinginmore cannabis productionandpossessioncharges,alongwithchargesrelatedtothe breakingof hisfirearms prohibition. (http://www.cumberlandnewsnow.com/Justice/2009-12-17/article-818327/Summons- issued-for-cannabis-crusader/1). Asa result,RickdecidedtostayinEurope for several years,wherehe continuedtoeducate people personallyandthroughhisorganization,Phoenix Tears. The 2009 charges were withdrawnin2012 by CrownattorneyDougShatfordaftera forfeiture applicationof seizeditems was approved(http://www.cumberlandnewsnow.com/News/Local/2012-05-14/article- 2978460/Charges-against-Simpson-withdrawn/1). Currently,RickandPhoenix Tearsare lookingtotake advantage of the legalizationlaw inColoradotoagain provide cannabisextractmedicine toanyone who needsit. Rick Simpson’sendeavortoheal people withcannabisoilwaspublicizedinthe documentary Run From theCure, releasedFebruary2008 (http://www.youtube.com/watch?v=pjhT9282-Tw). The documentaryelaboratesuponRick’sstoryandhow he discoveredcannabisoil couldeliminate various cancers andotherdiseases. The filmalsoprovidesstep-by-stepinstructionsonhow tomake cannabis oil and featuresinterviewswithcuredpatients,includingthose once deemedterminal. Itisof note that much betterprocessesforextractingcannabisoil have beendiscoveredsince the publishingof Run From the Cure. Alcohol,vegetable oil,carbondioxide,and othernon-petroleum-basedsolventsare fast becomingthe choice waystoprocesscannabisintoextracts. Furtherdiscussedinthe documentaryisanincidentinvolvingRickDwyer,formerpresidentof the Maccan Branch of the Royal CanadianLegion. AfterseeingsuccesswithhisfatherEdforterminal lungcancer, Dwyertriedtoshare the informationthroughhisLegionbranch. However,uponlearningof whatthe branchwas promoting,ProvincialCommandintervenedandremovedDwyerfromhisposition, claimingthatadvocatingthe use of an illegal substance wasunacceptable (http://www.canada.com/globaltv/national/story.html?id=70817eb6-a515-4af7-bf0d-3050413f0ebc).
  17. 17. 17 Thistrendof disregardanddisbelief forcannabisextractmedicinehasbeenaperpetuallystrong presence. RickDwyer’sincidentwasonlythe beginning –RickSimpsonalsoexperiencedrejectionfrom everyorganizationhe contacted,includingcancerresearchcenters. He offeredtopresentevidence directlyfrompatientsprovingthe effectivenessof cannabisoil,butnoone listened. Itwasnot even until August2013 that the firsttrulymainstreamtestimonial forcannabisextractmedicinewasshown to the world,inthe form of Dr. SanjayGupta’s Weed documentaryanditsdiscussionof child-patient Charlotte Figi. Throughthe use of non-psychoactivehigh-cannabidiol oil (whichdiffersfromtraditional psychoactive high-THCoil),Charlotte’sseizuresdroppedfrom300 grand mal seizures aweektoless than three minorseizuresamonth. The use of cannabisoil wascommencedonlyaftereverypossible combinationof powerfulpharmaceuticalsfailed. Threehundred severeseizures a weekto less than three minorseizures a month. Charlotte’scase isjustthe latestinanincrediblylonganddiverselistof successesthathave beenachievedsincethe releaseof Run FromtheCure. Interestinglyenough,RickSimpsoniscitedinthe November2013 CaseReportsin Oncology study inthe previoussection,ashe helpedassistthe studiedpatientwithproducingherownoil. Run From theCure was directedbyChristianLaurette,whohimself hadaverypositive healing experience withcannabisoilforbackproblems. He iscurrentlydirecting Run FromtheCure2, whichwill feature manyof the developmentsthathave occurredsince the firstfilm.
  18. 18. 18 3. Individual Case Reports Patientshave alwaysbeenthe central focusof the cannabisextract movement;real people whohave facedreal prospectsof painand death,yetrecoveredsuccessfully throughthe use of cannabisextract medicine. The followingtestimonialsare pulledprimarilyfromsocial mediaandnewssources,aswell as frompersonal interviewsof the author. Several casesalsoinclude officialmedicaldocumentationof diagnosisandsubsequentremission. The most fittingplace tostart isthe documentary Run Fromthe Cure,whichfeaturedseveral patientswhoexperiencedincrediblehealingbenefits. Eric Donkinhad fouropen-heartsurgeriesandfive pacemakers,andthroughthe use of Rick’s oil,wasable to live life nearlypainfree andgobackto work. Doctorshad toldhimhe wouldonlybe able to siton the couch and watchTV for the restof hislife. Ericalsoremarkedthatthe oil waseffective for hisfather’scancer,andit was because of hisfatherthathe beganonthe oil aswell. Rick Dwyersufferedfrommajordepressionsince 27,alongwithpanicattacks. Three back injuriesresultedinchronicbackpainwithconstantaching. The oil cut downhispanic attacks,reduced back aches,and continuouslyimproveddepressionandanxietysymptoms. Debbie Donkinhadsuspectedskincanceronher shoulder,andafterusingthe oil fortwoweeks (byputtingthe oil ona bandage,andreapplyingoil/changingthe bandage afew timesthroughout),the site wascompletelyclear. Cecil Hoeghad melanomaonhisface,whichhadpreviouslybeentreatedmanytimeswith radiation. Althoughthe radiationtreatmentswere ineffective, Rick’scannabisoil provedeffective at finallygettingridof the cancer. Margaret Dwyerusedcannabisoil withefficacyformigraines,anovariancyst,arthritis,skin allergies,stomachproblems,and evensnoring. The most dramaticcase featuredisJamesLaBlanc,a patientwithterminal cancerwhowas healedwithcannabisoil. WhileJames’storyisrelativelybrief inthe documentary,the authorof this reportspoke extensivelywithJamesin2008, and recorded several importantdetails. Some information isalso takenfromthe original incarnationof the Phoenix Tearswebsite.
  19. 19. 19 Jameswasdiagnosedwithstomachcanceron May 18th , 2005. Overthe subsequentfew months, LeBlancenduredsurgery,chemotherapy,andradiationtreatments. OnNovember30th , 2005, the cancer wasvirtuallygone. ItreturnedinOctober2006, and thistime hadspreadthroughoutJames’ lymphnode system. InNovember2006, LeBlancwas giventwomonthsto live,asthe cancer was completelyuntreatable. Onlypalliativemedicinewasprescribed. ItwasinDecember2006 that LeBlanc became aware of cannabisoil,andwas broughtto AmhersttomeetRickSimpson. He was initially skeptical of the endeavor–like mostpeople atthe time,he wasusingcannabisoil asa last resortwith little hope. AfterspeakingextensivelywithRick,LeBlanc’shopeswere raisedandhe startedthe oil on January1st , 2007. OnApril 4th , 2007, LeBlanchad hisfirstCT scan since startingthe oil andreceivedthe resultsonApril 24th . The doctor presentedJameswithextremelygoodnews;notonlywasthe cancer not spreading,butitwasdying. By late July,the secondCTscan showedthatonlya small bitof cancer remained,andbythe final CTscan in December2007, the cancer wascompletelygone. Afterbeating terminal cancer,Jamesreturnedtowork. Rick Dwyer,apatientmentionedabove andformerpresidentof the Maccan Branch of the Royal CanadianLegion,spoke onGlobal MaritimesEveningNewsinDecember2006. He spoke aboutissues withthe RCMP and the successhisfather, 82-year-oldEdDwyer, experienced throughcannabisoil consumption. The treatmenthelpeddrainfluidfromEd’slungs,repairhisprostate,andeliminate his needforinsulintocontrol hisdiabetes. Throughthe use of cannabisoil,the fluidfromEd’slungswas drained,hisprostate wasrepaired,andhe nolongerneededtotake insulinforcontrollinghisdiabetes. Most importantly, Ed’sterminal lungcancerwasheldatbay,despite atone pointhavinga prognosisof only24 hoursto live. Later inthe documentary,RickDwyer discussedhow he came tomeetRick Simpson andlearn the truth of his claims bytalkingwithcuredpatients. AsDwyer stated,“IinvestigateditasI should’ve.” Despite effortstoshare the informationwithProvincial Commandandsolicitanhonestreview of the claims,theydidnotlisten. Dwyerevenstartedapetitionaskingparliamenttoenactlegislationin supportof clinical testingoncannabisoil.
  20. 20. 20 Insteadof examiningthe evidence,LegionCommandcame inandshutdownthe Maccan Branch. Rick Dwyer’seffortstoshare the scientificandhumanevidence were ignored. Provincial Commandonly cared that the Royal CanadianLegionname andinsigniawere notusedtopromote illegal information. Steve Wessel,CommandChairmanof NovaScotia,said sharingsuchinformationcoulddamage the integrityandreputationof the Legion. Giventhatno actual medical documentationof curative resultswere includedin Run Fromthe Cure,the documentary wasinitially,andstill tothisday,metwithheavyskepticism. Tocounterthis skepticism, Rick Simpsonsimplystated,“If youdon’tbelieveme,putsome oil onaskincancer, and watch itdisappear.” Indeed,since the 2008 release of Run FromtheCure,thousandsof people have takenthischallenge andmore, seeingRick’sseeminglyabsurdclaimsconfirmedtime andtime again. DavidTripletttreatedskincanceronhisnose withcannabisoil,anddocumentedthe curative resultsinhismini-filmCured:A CannabisStory,releasedinJuly2010. (http://www.youtube.com/watch?v=JPm0Jq9bj98).
  21. 21. 21
  22. 22. 22 The above imagesare capturedfrom the documentary,whichalsoincludesfurtherimagesand information. A womannamedMaggie Perondiscussedthe use of cannabisoil forher65-year oldfather,who had squamouscell carcinomaonhishands(http://www.youtube.com/watch?v=Ui68B_rjzLk). He hadto deal withconstantscabs,pus,sores,and pain. Maggie boughtcannabisoil fromGersh Avery,whooften goesby the pseudonymPeanutButter. She convincedherdadtotry it topicallyone night,andthe very nextdayhe reportedsubstantiallyreducedpain. Overamonth,the scabs and soresalmostcompletely disappeared. Hardlyanyscaring,and pushad gone away completely. Maggie:“That’sthe mainthing, there’snopain.” GershAveryhas treatedmanypeople andinformallycollectedreportedresultsinaspreadsheet. He insistedthiswasnota formal studyinthe slightest,andwasjustobservationshe collectedfrom patients. Ratingsare on a 1 to 10 scale,with1 beingthe leastsevere and10 beingthe mostsevere symptomintensity. Measuredsymptomsincludeacid,tension,gurgling,diarrhea,andpain.
  23. 23. 23 A newsreportfeaturinganchorsEricSingerandHeatherSkoldof ABC NewsChannel 13discussedthe use of cannabisoil forneckcancer (http://www.youtube.com/watch?v=0F3mTf1z3Yo). BrettStrauss firsthad cancer in2007, andafter beatingittraditionally,the cancerreturnedinthe formof five malignanttumorsinJanuary2010. He decidedtotrytopicallyusingacannabisextractbalmon hisneck, and inMarch 2010, doctorsconfirmedonly one tumorwasmalignant. Afterthisexperience,Brett wantedtoresearchthe effectsof cannabisoil forothercancerpatients. Althoughthere isnofurther readilyavailable material regardingBrett’sendeavororfurthercancertreatment,hisstoryis notable nonetheless. ShonaBanda isa particularlyunique patientandactivistwhohas Crohn’sdisease. Shonabattledfor eightyearsagainsta verysevere case of Crohn’s,usinganarray of powerful pharmaceuticalsincluding Remicade,which oftenhasseriousandpainful side effects. Whenshe beganusingcannabisoil inMarch
  24. 24. 24 2009, herconditiongreatlyimproved. The drastic,overwhelmingsuccesspromptedShonatowrite a bookabout herexperience called LiveFree or Die. The bookstartedas a journal thatShonakeptto documentthe effectsof cannabisoil,andshe expandeduponthe journal withotherinformation to create her book. Live Free or Die isespeciallypowerful becauseof Shona’scourage toreveal the specific waysin whichCrohn’saffectedherlife. Onseveral occasionsshe thoughtshe wasgoingtodie. The other interestingaspectof Shona’sstoryisthe wayshe producedcannabisoil. Havingseen Run From theCure and knowingshe couldn’tacquire the recommendedamountsof cannabistomake oil from(inthe documentary,apoundor as little asone ounce isrecommended),Shonabelievedshe wouldnevertryit. However,aftervaporizingcannabisinaglobe-type device,she noticedresidue accruing alongthe sides,whichlookedlikethe cannabisoil she’dseenin Run FromtheCure. With nothingtolose,Shonabegancollectingandconsumingthe oil residue incapsules. Withinaweekanda half,she noticedremarkable improvements; althoughsome abdominal paininitiallyintensified, Shona attributedthistoscar tissue changingandfallingoff. Overthe nextfew months,asidefromperiods where cannabiswasunavailable,Shonacontinuouslyimproved. She wentfromliterallybeingonthe verge of deathto feelingalmostcompletelydisease-free. The detailsinherbookare trulyremarkable, and a must-readforanyone legitimatelyinterestedinthisissue. The painShonaovercame withher improvisedformof cannabisoil isnothingshortof incredible. Furthermore,otherpatientswithout access to large amountsof cannabishave usedhervaporizationmethodtomake oil fromsmall quantities. Shonarecordedabrief summaryof herstory in2010 (http://www.youtube.com/watch?v=4cQrT0sDxyc). Herbook Live Free orDie is available inhardcopy and the Kindle (http://www.amazon.com/Live-Free-Die-Reclaim-Life/dp/1449045561 and http://www.amazon.com/Live-Free-or-Die-ebook/dp/B005GHM244). A videopostedonOctober5,2011 discussedthe storyof anelderlywomanwhoovercame Stage IV cancer and lupuswithcannabisoil (http://www.youtube.com/watch?v=jxis8lqaEGE). InJanuary2011, the woman(knownas“Granny”) was toldshe had“days, weeksatthe most” tolive,asher condition was especially taxing. Inadditiontothe cancer, she was paralyzedfromthe leftside of herface,starting
  25. 25. 25 fromthe jaw, to the waist. A compassionate strangerlearnedof herstoryand donated cannabisoil to help. A litanyof improvementsimmediatelystarted afterGrannybeganthe treatment,including reductionof tumors,almostcomplete eliminationof chronicpain,ceasingof constantvomiting,and remarkable concurrentimprovementsforlupusandfibromyalgia. Grannyforewentchemotherapyand surgeryforthis path,and stronglybelieves,basedonthe poorprognosisfromdoctorsandthe state she was in,that if notfor cannabisoil she wouldbe dead. Cannabisoil hasprovento be effectiveagainstevenlong-standingchronicpain (http://www.youtube.com/watch?v=gu5VNQHxKkU). A videoreleasedinOctober2011 featuresTomas Harner,who for30 years enduredbackpainas a resultof accidents. Inthe last 10 years,he saidhis conditionbecame worse,anddoingsimple tasks likeputtingonshoeswere becomingdifficult. Within the firstweekof consumingcannabisoil,the sharppainswhichinhibitedhismovementswere gone. Tomas maintains awarenessof hisinjury,butthe vastmajorityof his painhas disappearedandhisrange of movementhasimproveddramatically. He believesthattakingmore oil will eliminate remnantsof pain.
  26. 26. 26 A medicinal cannabisoil producernamedAamannDegarthhas observed amazingresultswithcannabis oil,andhas documentedthe resultsinsharedvideos. One November2011 account detailshiswork withreflex sympatheticdystrophy,now more commonlyknownascomplex regionalpainsyndrome (http://www.youtube.com/watch?v=Xvw19POCN4g). Aamannwasreferredtothe RSDpatientbya friend,andmanagedto procure oil for her. The patienthadextremelylittle experience withcannabis, and Aamanntookmeasurestoensure she startedoff slowly. He packagedthe oil invariousdelivery mechanismsandsentit off. He wasunsure of what the effectswouldbe,asRSDwas a conditionhe hadn’theardof. The day afterstartingthe oil,the patientreportedbeingpainfree,rightfromthe first dose. Aamannwassurprisedbythe speedof thisparticulartreatment. A laterJune 2012 videofrom Aamannprovidedanupdate onRSD/CRPStreatmentswithcannabisoil,reportingthatotherpatients had experiencedimmense success(http://www.youtube.com/watch?v=OvEztT4VHCg). Again,even small amountsof oil were reportedtobe effective atstoppingpain. Aamannhas treatedanddocumentedawide varietyof conditions,includingallergies (http://www.youtube.com/watch?v=V0fgTIorzXI),ADD (http://www.youtube.com/watch?v=C4ljMHUW4uI),neuropathy (http://www.youtube.com/watch?v=p4Y0CW10RTg),insomnia (http://www.youtube.com/watch?v=n1odhWwHSps),cyclical vomitingsyndrome (http://www.youtube.com/watch?v=3tVtUf1hTQs), lymedisease (http://www.youtube.com/watch?v=d_HAOkPSzgw)andmore. A particularlyintensecase describesa patient’sexperience withtrigeminal neuralgia,aconditionsoterrible itisnicknamed“suicidedisease.” TN isa neuropathicdisorderthatinvolvesepisodesof intense,stabbingpaintothe face. Aamann providedcannabis oil toa TN patientand observedthatit worked remarkablywell,withthe patient reportingzeroproblems (http://www.youtube.com/watch?v=S495AUPbka0). Before movingforward,itisimportanttohighlightthe trendregardingcannabisoilandpain. Currently,the primarytreatmentforpainisopiates. Manypatientshave reportedthatnotonlyare opiatesineffectiveoverthe long-term,buttheycause immense physical discomfort,cloudinessof the
  27. 27. 27 mind,andorgan damage. So manypatientshave stronglyinsisted thatcannabisoil isfarmore effective than opiateswithnone of the side effects. Theyfeel cannabinoidtreatmentattacksthe rootsof their pain,ratherthan providingamere numbingeffect. Sucheffectsare difficulttoobjectivelymeasure because theyare entirelysubjective,butthisremarkablystrongtrendissomethingthatcannotbe ignored. A January2012 videofeaturingthree patients,Mike Stone, Tom,andJeff,illustratedthe benefitsof cannabisoil formultiplesclerosis,rheumatoidarthritis,andmesothelioma (http://www.youtube.com/watch?v=V-uGtEHzZUE). Mike hadbeendiagnosedwithrelapsing-remitting multiple sclerosis17 yearspriorto the video’sfilming. Tocombat the disease,he wasprescribedalitany of drugs,whichcreatedmanyunpleasantside effects,includingsuicidalthoughts. AfterseeingRun Fromthe Cure,Mike decidedtotry a 90-day cannabisoil treatmentprogram. He concurrentlyceased all use of pharmaceuticals. He foundthe oil to workveryeffectively,whileeliminating the remainingside effectsfrompriorpharmaceutical use. The nextpatientfeatured,Tom,wasdiagnosedfouryearspriortofilmingwithsevere rheumatoid arthritis. Lack of treatmentformanyyearscausedextensive damage inhishands. TommetMike Stone, the above patient,ata May 2011 medicinal cannabisinformational meeting. Mike toldTomaboutthe potential benefitsof cannabisoil,andTomwasable to secure some. He startedwithone small dose a day forthe monthof June, while stilltaking hispreviouspharmaceuticals. Afteramonth,he decidedto go for the full 90-daytreatment. InearlyAugust2011, he stoppedtakingmethotrexate,a chemotherapydrugalsousedforrheumatoidarthritis, whichcausedespeciallysevere side effects. By August25th , he startedtakingcannabisoil three timesaday for90 days. Tom’srheumatologisttoldhim that swellingwasanindicatorof if hisrheumatoidarthritiswasactive – afterthe treatment,Tom’s swellingcompletelydisappeared,indicatingapparentinhibitionof the disease. He currentlytakesone dose of oil a day to helphimsleepatnightandkeepthe effectsof rheumatoidarthritisatbay.
  28. 28. 28 The third personinthe film,Jeff,foundouthe hadfive tumorsonhisleftlung, diagnosedas mesothelioma. Like Tom,Jeff foundoutaboutcannabisoil from Mike Stone. Mike showedJeff howto make hisowncannabisoil,andJeff begantreatinghimself byputtingtwodropsonhistongue every morningwithaneyedropper. OnDecember21st ,2011, Jeff wastoldall histumorswere gone andhe was cancerfree. “BestChristmaspresentIeverhad,”remarkedJeff. He alsostoppedtakinghisblood pressure medication, givenhisBPhad normalized. Jeff isalsosuccessfullycontrollinghisdiabetes,with hissugar levelsneverbeingover110. He’s off hisallergymedicinesandcholesterol medicinesaswell. He still hassome problemsbreathingasa resultof emphysema. However,overall,Jefffeelshislife has drasticallyimproved. At an eventknownas“Uncle Pete’sCannabisCamp”inJune 2012, where people are taughtaboutthe healingeffectsof cannabisoil alongwithhow tomake it,the testimonial of Joe Crowe wasrecorded (http://www.youtube.com/watch?v=W0nwqBtxXKc). Joe hada fist-sizedtumorinhisupperchest, diagnosedasHodgkin’slymphoma. He hadpreviouslyreceived chemotherapyandbone marrow transplants,butthe treatments were ineffective. Inthe fall of 2011, Joe wasconnectedwithGrow Goddess,a female caregiverinMichigan. The properformswere filedforGrow Goddesstolegally
  29. 29. 29 become Joe’scaregiver. Withinthree months of cannabisoil treatment,Joe felthistumorbeganto shrink. By five months,he wascancerfree. On December4th ,2013, Joe releasedanupdate videostatinghe isstill cancerfree afterayear (https://www.youtube.com/watch?v=-spOVv8EobU). He emphasizedthe importanceof continuingto take a maintenance dose of oil topreventcancerfromreturning,especiallydue tothe large amountof environmental toxinshumansare exposedtodaily. Joe now helps otherpeoplemake anduse cannabis oil therapeutically,andatthe endof the videorecountsanexperiencewithaStage IV cancer patient whowentintoremissionwith self-madeoil. A case veryclose to the author isthat of DennisHill. Dennisisanestablishedteacherof meditative practices,andhas writtenseveral booksonmeditationandyoga. He alsoworkedinthe fieldof cancer researchforten years. In February2010, six biopsiesrevealedhighlyinvasive andaggressive prostate cancer.
  30. 30. 30
  31. 31. 31 Denniswas stunnedtohearthisdiagnosis afterhavinglivedsucha healthylife,butgiventhatprostate cancer wasprevalentinhis family,he knew the possibilityhadalwaysexisted. Priorexperience in cancer researchmade Denniswanttoavoid the traditional routesof chemotherapy,radiation,or surgery,giventhe likelypainful sideeffects. He beganto researchalternativemethodsof cancer treatment,andlearnedaboutcannabisoil. Ashe researchedfurther,he decidedthiswasthe pathfor him. Dennis’treatmentjournal,startingonJuly8,2010, isrecordedonline (https://dl.dropboxusercontent.com/u/27713298/Web/cure/Treatment.html). However,priortothe firstentry,Dennis hadbeenconsumingcannabis-infusedbutter,ashe hadnot acquiredfull-strengthoil yet. Afterprocuringsuchoil,hisconditionsteadilyimproved,until aprostate biopsywastakenon January25, 2011 to determine if the cancerwasgoingintoremission. OnFebruary8th , 2011, Dennis receivedthe newsthathe wascancer free (https://dl.dropboxusercontent.com/u/27713298/Web/cure/Cured.html). The onlypharmaceutical- type treatmentDennisreceivedthroughthisperiodwasthree injectionsof Lupron,anandrogen antagonistwhichcanpotentiallyslowthe rate of cancer growth. However,italone cannotleadtothe shrinkage of tumors.
  32. 32. 32 Dennisalsoappearedona programcalled“Spiral Up withAvaMarie” to tell hisstory (http://www.youtube.com/watch?v=Q7ytJu4Zcrk).
  33. 33. 33 Denniscontinues totake amaintenance dose of cannabisoil andhasintegratedcancer-fightingfoods intohisdietto ensure he stayshealthy. DustyFrank, a local musician,wasdiagnosedwithprostatecancerinOctober2013 (http://www.cureyourowncancer.org/dusty-franks-story-beating-prostate-cancer-with-cannabis- oil.html). The traditional optionshe waspresentedwithwerenotpreferable due tonegativeside effects,andDustywantedanalternative. He quicklylearnedaboutcannabis oil,andextractedhisown fromraw cannabis. Althoughhisdoctorsadvisedagainstthe treatmentandDustyhimself haddoubts aboutthe oil’sefficacy,he wentaheadwithathree monthregiment. OnJanuary23rd , 2014, a Tesla3 MRI reportstatedthere were nolongeranysignsof cancer (medical documentationfoundatlink above). Perhapsevenmore remarkable thanthe cancerremission wereall the otherside benefits. Bloodpressure normalizedandrelevantmedicationswere discontinued. Aninflamedbig toe joint normalized. Rectal bleeding,chronicspinal pain,shoulderandneckpain,andchronic insomniawere resolved. Sinusproblems,includingpostnasal drip,resolved. Depressionresolved. Severalof these issueshadplaguedDustyforwell overa decade. Furthermore,atleasteightpharmaceutical medicationshave beenreplacedwithcannabisextractmedicine,andthe onlypill Dustytakesnowisa single multi-vitamin. Dustyalso sharedhisstoryon YouTube (https://www.youtube.com/watch?v=SGPTXq6dZHg). He intimatelydescribedhisexperience,whichrepresentswhatmostpatientswhouse thismedicinego through. Interestinglyenough,if Dustyhadnotbegunseeingotherremarkablebenefitsfromcannabis extractsmere daysintohistherapy,he may have stoppedoutof skepticism.
  34. 34. 34 MykaylaComstock,a childpatient,hasattractedsignificantattentionrelatedtoherbattle withcancer. In July 2012, Mykaylawas diagnosedwithT-cell acute lymphoblasticleukemia. Feelingsickthroughout May wasthe chief signthat somethinginMykaylawaswrong. The child’smother,ErinPurchase, immediatelyprocuredalegal recommendationforcannabis. MykaylabeganchemotherapyonJuly17th , 2012. Accordingto a local ABC Newsarticle, “Atfirst,Mykaylawasn'trespondingwell tohertreatment, and doctorssaidshe mightneeda bone marrow transplant.Thenshe startedtakingthe cannabisoil pills, hermothersaid.ByearlyAugust,Mykaylawasinremissionandthe transplantwasnolonger necessary”(http://abcnews.go.com/Health/medical-marijuana-year-sparks- controversy/story?id=17814636). Erin alsonotedthat withcannabisoil,Mykaylawasable to avoid usingtraditional painornauseapills,andhasnotlosta single poundsince diagnosis. ByAugust6th , less than a monthafterstartingtraditional therapy,Mykaylawasinremission. She isrequiredbythe medical systemtoundergotwo-and-a-half tothree more yearsof chemotherapytobe certainthe cancer isgone. Nonetheless,the rapiddisappearanceof cancerfromMykayla’sbloodandthe lack of side effectsfromchemotherapyare astoundingfacts. Evenforan adult,chemotherapy usually producesintense sideeffects –fora child,sucheffectsare oftenmuchworse. More informationabout Mykayla’sexperience canbe foundhere: http://www.bravemykayla.com/Her_Treatment.html
  35. 35. 35 As of February2014, Mykayla continuestodoverywell,andhasbeenincreasinglyfeaturedinthe media. One suchinterview onVice.comhasreceivedalmosttwomillionviews (http://www.youtube.com/watch?v=TXKjRkkoIOU). The interview alsofeaturedStoneyGirl Gardens and the workof Frankie andErin Wallace,whoare discussedlater. Erin Purchase waspromptedtouse cannabisoil to helptreatMykayla’scancerbecause of the experience of anotherchildpatient,CashHyde. Cash’sstoryhasbeencoveredbyseveral newsoutlets and hishistorywas deeply explored inthe documentary American Drug War2: CannabisDestiny. On May 3rd , 2010, Cashwas diagnosedwithaStage IV braintumor. On May 5th , surgerywas performed,andhigh-dose chemotherapybegan. The Hydes,Mike andKalli, were toldthatevenwith bone marrowtransplants,Cashhad an 80% chance of dying. The combinationof chemotherapyand otherpharmaceuticalsresultedina2-weekICUstay,where the Hydeswere warnedof possibleorgan
  36. 36. 36 failure andbrainfailure. Asthe documentarygraphically depicts,Cash’sstate wasmorbidlysevere,and it isfranklystunninghowhe wasable tosurvive forso longthroughsomuch. In theirsearchto findsome wayto help theirson,the Hydesdiscoveredstoriesof cannabisoil healing cancer. The day of thisdiscovery,theymanagedtoacquire oil,andMike immediatelybegan sneakingit intoCash’sfeedingtube withoutthe doctorsknowing. Almostinstantly,Cashstartedtodrastically improve. Withintwoweeks,he wasable togetoff eightmedications,andhe startedtoeatand laugh again. His qualityof life changedcompletelyforthe better. Cashwasreleasedfromthe ICUinmid- December2010. His parentsbeganteachinghimhow tocrawl and walkagain,as hismotorskillshad markedlydecreasedasaresultof the cancer ordeal. InJanuary,brain scansrevealedCashwascancer free. Afterthe scans,Mike revealedtothe doctorsthat he had beensecretlyfeedingCashcannabisoil. The doctors were speechless,andthenattributedthe healingtoprayersratherthancannabisoil. As Mike said,"I believeinprayersand miracles,butIalsobelieveinnumbers,andatthe endof the dayit adds up." Nonetheless,hospital staff gatheredtowitnessCashleavingcancerfree,believingtheyhad seena miracle.
  37. 37. 37 Giventhe potential forarecurrence,the Hydescontinuedtoprovide Cashwithcannabisoil afterthe remissionnews. However,inMarch 2011, a seriesof federal raidsonmedicinal cannabissuppliers resultedinCash’soil supplybeingcutoff. Theyran outof medicine inJune. InOctober2011, a scan confirmedthe Hydes’worstfear- Cash’scancer hadreturned. Theycouldnot reestablishasolid cannabisoil supplierinMontana,andwenttoCaliforniainNovember2011 to attemptprotontherapy. Theyalsohopedto finda cannabisoil supplierinCalifornia,andgetCash restartedonthe medicine as soonas possible. UponarrivinginCalifornia,doctorsreaffirmedapoorprognosisforCash,and said there wasno hope of shrinkingthe tumor. In December2011, the Hydeswere putin contact with Ringo,a producerwhogave thema 90-day supplyof cannabisoil forfree. Withthe combinationof protontherapyand cannabisoil,Cashwentintoremissionforasecondtime inJanuary2012. Mike remarkedthatCash wasthe firstcancerpatientto go through30 roundsof protonradiationtreatment withoutusinganynauseaor painmedicationbesidescannabisoil. Afterrunningoutof oil,the Hydesagainwere notable to finda sustainable supply. Andagain, inJuly2012, Cash’scancer returnedforthe thirdand final time. Thisthirdfightwasultimatelytoomuch for a childsoyoung,and Cash passedawayNovember14th , 2012 inMike’sarms,a final momentthe Hydesare thankful for. Hadhe died inthe hospital whileunderthe influence of several powerful pharmaceutical drugs,the passingsurelywouldnothave beenaspeaceful. Toshare Cash’sstory and informationaboutthe healingeffectsof cannabisoil,the Hydesstartedthe CashHyde Foundation (http://www.cashhydefoundation.com/).
  38. 38. 38 In the November2013 issue of DOPE Magazine,the storyof SilasTedescowasdescribed (http://issuu.com/dlistmagazine/docs/dope_nov13_web_). SilaswasdiagnosedwithPrecursorBacute lymphoblasticleukemia,andsoonbeganchemotherapy. The treatmentswereveryharshandcaused general sickness,insomnia,andanearlyeight-weekperiodof immobility. Silas’doctorthen recommendedhigh-CBDcannabisoil. Asthe article concludes, “Afteronlyeightdaysoncannabis,Silasbegantowalk,talk,smile andplayagain.Itwas a complete turnaround.Silasisnowinremissionandrunningaroundlikeanaverage two-yearold. His leukemiaisinremissionandisshowingimprovementseveryday.” There are several othernotable childpatients,includingCharlotte Figi,JaydenDavid,and LandonRiddle,whoare discussedinthe Doctor and Team Operations section. The most dramaticrecoveriesare those involvingterminal cancer- where apatientistoldthey are goingto die,and doctorscan offerno furthertraditional treatmenttohelp. Eveninthese cases, cannabisoil hasproveneffective. Corrie Yellandisone suchcase. Her self-toldfullstory andmedical documentationof herexperience withterminal anal canal cancercan be foundat http://cannabisnationradio.com/corrie-yelland. These documentsare alsodirectlyreplicatedbelowfor convenience.
  39. 39. 39 Hi, My name's Corrie. I'm 55 years old. In May of 2007, I had a heart attack and subsequently had a double bypass . As a result of the heart surgery, for 4 plus years, I have been plagued with chronic debilitating pain from a maligned sternum and post sternotomy neuralgia/syndrome. I was ingesting copious amounts of various pain killers 24/7. They barely touched the pain. I spent my days in agony, waiting for evening so I could try to sleep. I took sleeping pills nightly in a futile attempt to escape the hell I was going through and failed miserably. Within 2 hours of taking the pills, I would awake in agony. Fast forward to July of 2011. Already coping with 2 spots of skin cancer on my collar bone, I was stunned when I was diagnosed with Anal Canal Cancer. (This is the same cancer that took Farrah Fawcett's life.) Following 2 surgeries, the doctor told me they did not get all the cancer and I would have to endure a regime of radiation treatments. I started researching what this would entail, and attended a intake meeting at the Cancer Clinic. I was informed that "this is the worst area of of the body to radiate", the radiation beam would hit both my coccyx and pubic bone potentially causing permanent damage." They would try not to hit my spine. Additionally, I would suffer 2nd and 3rd degree burns vaginally, rectally, across my buttocks, as well as my entire "nether regions", and there was a "good possibility" both my vagina and rectum would fuse shut from the burns and subsequent scaring. The list of both short and long term side effects was endless and horrendous, but you get the gist. I told the doctor, I needed time to think about it. His response was hostile, as he told me I had 2-4 months, possibly 6. He murmured something abut a "death wish" and walked out. One day someone sent me Rick Simpson's video, Run From The Cure. It took me days to get around to watching it, but when I did I was blown away. Here was this man, a seemingly super straight small town Nova Scotian, talking about these amazing results he had seen with in himself and other people taking Cannabis and curing themselves of a myriad of diseases including end stage cancers. After hearing what Rick had to say, and watching the testimonials in the video, I was feeling some hope for the first time. For 2 weeks I did nothing but research cannabis as a medicine. I was stunned by the sheer number of studies on Pub Med indicating that cannabis indeed has the capacity to heal. I started using cannabis 2 months ago as per Rick Simpson's protocol from his video. (He recommends starting out small, and slowly upping the dose so ones' body becomes accustomed to it, without being high constantly. As a person who hasn't smoked pot since my late teens, early 20's, the non high aspect appealed to me). I had huge hopes to cure my cancer, and embarked on my fight to live. As well as ingesting the cannabis oil, I topically applied it to 2 spots of skin cancer on my collar bone. Within 48 hours, there were visible changes. In just over a week, the 2 spots were completely gone. Elated, I continued ingesting the oil, in hopes it would work on the other cancer attacking my body. Nothing prepared me for what happened next. About 2 weeks into my regime, the pain in my
  40. 40. 40 sternum, as well as the nerve pain had become almost non existent. You have to understand, I had resigned myself to a life sentence of pain and agony. It had been 4 years of pain that was with me 24/7 and never, in my wildest dreams, did I imagine I would be pain free ever again. I was able to stand up straight, the jolting pain so intense that it would cause me to cry out, ceased completely. I started to sleep through the night and stopped taking sleeping pills. I saw one of my doctors a couple of weeks ago and was thrilled to hear he believes there is a decrease in both the size and number of tumours. I know in my heart it is only a matter of time before I will be completely cured. Even the most skeptical of my friends comment on the visible changes in me. I have evolved from a pain wracked, hunched over, shuffling along individual, to a vibrant, high energy person. Even my complexion has improved. Before I started using cannabis, I typically took 10-15 Tylenol 3 a day, along with a smorgasbord of other drugs. Now, in a 24 hour period, a half a Tylenol 3 is all I need. I think it's understandable when I say I get very emotional when I think of how far I've come. Not only has cannabis changed my life, it is SAVING my life. P.S. When researching,I met a woman in Texas diagnosed with the same cancer that I have. Diagnosed at the same time, we felt fortunate to have found each other, as we were identical in every aspect. I. E. same age, same diagnostic procedure, same stage of the cancer with radiation recommended as treatment. She chose to have the radiation. I'm very sad to tell you she died 2 weeks ago, as a result of infection from radiation burns. She left behind a husband and 12 year old daughter. The above was written (March 2012) I continued ingesting the oil on a daily basis, slowly, ever so slowly increasing the amount I was taking. As well, I began filling gelatin capsules with a mixture of the cannabis oil and olive oil and inserting them rectally. I thought to myself, if the oil worked being applied directly to skin cancers, wounds etc. why wouldn't it work there? Get it closer to the source, get it closer to the problem area. At the end of May, I saw the doctor who first discovered my cancer. I was in the operating room for a non related problem. At the time, I was told he could no longer manually or visually detect any cancer. Elated, for the first time I dared to hope, that maybe, just MAYBE the cannabis oil was working. Because the cancer was not this particular doctor's area of expertise, I was hesitant to become too excited. I was no longer taking any pain killers and found myself thinking that if all the cannabis did was to hold it at bay, I would consider myself lucky. On September 20, 2012, I saw my specialist/surgeon, whom I had not seen for approximately 6 months. He examined me once, then a second time, and then a third time. My heart was pounding so loudly I could hear the whooshing in my ears. And then the news I had only dared to hope for. "It's gone! I can't find anything at all. If it wasn't for the scar tissue I would never have known you had ever had cancer." I was shaking, looking at him in disbelief. Tears streaming down
  41. 41. 41 my face, I hugged him mumbling, "thank you, thankyou." He looked at me, "No, Thank YOU! You're the one that did this. You DID it Corrie! You pulled it off, you pulled it off! No doctor, CANNABIS OIL and I pulled it off! I received confirmation that the cancer is well and truly 100% confirmed to be gone. Doc. 1 is when I was first diagnosed. The doctor's explained to me that my tumours looked like cauliflowers. They had cut off the heads of these "cauliflowers" and now what was left and could be seen with the naked eye were stems and then of course roots. I had these both internally and externally. This is when I was told I would require radiation. Doc. 2 is my report to my GP from the specialist when I first saw him after not having seen him for a year. The report is results of what he could see, (or should I say NOT see :-) )This is the visit where he examined me 3 times, because he couldn't believe he couldn't find anything. :-) Doc. 3 is the result of my biopsy from approx. 14 mos. after the start of cannabis oil treatment.
  42. 42. 42 Document 1
  43. 43. 43 Document 2
  44. 44. 44 Document 3
  45. 45. 45 Anothernotable terminalcancersurvivorisJoanne Crowther,who directly providedthe authorof this reportwithherfull storyand medical documentation. Joanne spoke onthe stepsof the VancouverArt GalleryonAugust25th , 2013 to tell othersof herexperience. She isextremelypassionateaboutmaking cannabisextractmedicine available toeveryone.
  46. 46. 46 Joanne wasdiagnosedwithlarge B-celllymphomainsummer2009. The lymphomawaseliminatedwith chemotherapyinFebruary2010. The treatmentcausedsignificant nausea,vomiting,febrile neutropenia(feverresultingfromabnormallylow white bloodcellcount),andpneumoniarequiring hospitalization. InMarch 2010, a brainMRI revealedseveral cancerouslesions. These were resolvedby April 2010 withwhole brainradiation,asindicatedbyapost-treatmentMRI. For a year-and-a-half,Joannewasdoingverywell,evenparticipatinginahalf-marathon. However,inNovember2011, a mass developedinherleftthigh. Doctorsremovedthe 3.2x 2.5cm mass,and determineditwasconsistentwith diffuselarge B-cellintravascularlymphoma. The removal of thismassdidnot eliminatethe lymphoma. InearlyJanuary2012, Joanne beganreceiving medicationstotreatcomplicationsof the cancer. Furthermore,anotherheadCTscan revealeda6mm cancer lesioninthe leftsuperiorpons. The testalso confirmed resolutionof the previouslesionsinthe rightthalamusand basal ganglia. Shortlyafterthe 3.2 x 2.5cm massexcision,Joanne noticedregrowth of some mass inthe same area. She receivedfive shotsof radiationinJanuaryforthe new growth. More scans inFebruary2012 revealednew adrenalcancerousnodules. Joanne begantakingthe chemotherapydrugscisplatinandcytabarine tocombatthe cancers. She was thenhospitalized betweenApril23rd ,2012 and May 3rd , 2012 due to acute renal failure andhepatitis,whichhad been inducedbycisplatinandcytabarine respectively. The complicationspermanentlyendedJoanne’s chemotherapyregiment,withchemotherapystoppinginlate April. Joanne wasthendiagnosedwith relapsedintravasculardiffuse large B-cell lymphoma,and leptomeningeal disease. Withoutthe strengthto endure more chemotherapyorradiation,doctorscoulddonothing more,and Joanne wasforcedto try an alternative treatment. InearlyMay, she begantakingcannabis oil. She startedoff withsmall rice-grainsizeddoses,butafteraweek feltnoeffects. She thenupped herdosage to a gram of oil a day, andwithintwoweeksnoticedbeneficial effects –ingeneral,feeling betterandhavingmore appetite. OnJuly30th , 2012, Joanne hada follow-upexamination. The documentationresultingfromthe examinationisbelow. Itdescribeshow Joanne isdoingmuchbetter since beingoff chemotherapy,andthatthe leftthighmass“actuallyregressedspontaneously.”
  47. 47. 47 AnotherexamfromSeptember24th ,2012 statesJoanne isnow inremission. The reportalsonotesthat she had beentakingregularhempoil supplements(referringtocannabisoil,nothempseedoil).
  48. 48. 48
  49. 49. 49 Furtherdocumentationof Joanne’sfinal appointmentsis recordedbelow. There are afew key thingsto note. Firstoff,there isan error inthe line,“She istakingcertainorganicoils,whichrobherof appetite, accordingto the patient.” Uponinquiryof thisoddstatement,Joanne informedthe authorthiswasan error,and she had actuallysaidithelpedherappetite,butforsome reasonitwas incorrectly recorded. These documentsalsoincludethe recordof Joanne beingtoldshe waslookingata palliative situation afterabandoningchemotherapy. Finally,andmostimportantly,theyrecordherclinical remission,with Dr. JohnW. S. Yun stating,“She made miraculousrecoverywithstableclinical conditionwithnofurther cranial nerve palsy.”
  50. 50. 50
  51. 51. 51 In late January,2014, Joanne appearedonCBC Newsspeakingaboutherstoryandthe new Canadian medical marijuanaregulations (http://www.youtube.com/watch?v=PejeP7GFEg0).
  52. 52. 52 A case close to the cannabispolicyreformmovementasa whole isthatof Michelle Aldrich. Michelle has workedindrugpolicy reformforseveral decadesandisa well-knownfigure. Recently,inthe Winter/Spring2013 issue of O’Shaughnessy’s –TheJournalof Cannabisin Clinical Practice,Michelle told herstory (http://www.beyondthc.com/wp-content/uploads/2013/03/Michelle-BTHC.pdf). Hercancer experience ultimatelybeganNovember15th , 2011, whenMichelle missedalunchappointmentbecause she felttoosick. On November22nd ,Michelle wenttothe doctor,where she wasevaluatedbya physician’sassistantnamedSallyHolland. Michelle receivedachestx-rayandwas givenantibioticsfor bronchitis,althoughthe followingdaySallycalledMichelle toinformhershe hadpneumonia. Michelle returnedonNovember30th ,whenshe wastoldshe had a growthon herrightlung. Overthe next couple months,Michellewent toseveral appointmentstodetermineasoliddiagnosis. A CT scan on December23rd revealeda23 x 28mm tumor. A growthon the leftkidneywasalsoobserved. On January12th , 2012, Michelle wasnotifiedbyDr.Gary Feldman,herprimarycare physician,thather cancer waspoorlydifferentiatednon-smallcell adenocarcinoma. Michelleimmediatelystartedreaching out to friendsforsupport,andwas calledbyDr. DonaldAbrams,a long-time friend. Dr.Abrams appearedinthe documentary American Drug War2, discussedabove inthe storyaboutCashHyde,to talkabout medicinal cannabis. Dr.Andrew Weil,alsoafriendof Michelle,offeredherhelpandsupport. These people,combinedwithotherreferredoncologists,were Michelle’s“dreamteam”. In mid-January,Michellespoke withJeannie Herer,widow of the late JackHerer,one of the mostwell-knowncannabis activistsinhistory. Towardsthe endof hislife,Jackhadactuallybecome a majorsupporterof Rick Simpson. JeannietoldMichelle tobeginusing“RickSimpsonoil”toassistwith treatment. Michelle acquiredanextractfromValerie Corral,founderof the Wo/Men’sAlliance for Medical Marijuana. Valerie callshermedicine “Milagrooil”,withmilagrobeingSpanishformiracle. Michelle receivedthe firstbatchof milagrooil onJanuary21st , 2012. Three days later,a PET scan showedMichelle’stumorhadgrownto30 x 31mm, whichcouldhave eitherbeena“betterpicture”or the tumor had reallygrown. AfteraJanuary25th endobronchioscopic ultrasoundfine-needleaspirationbiopsy,the final diagnosiswas “Stage 3A poorlydifferentiatednon- small cell metastaticadenocarcinomaof the rightlungwithbulkylymphnode involvement. Atleast three of the lymphnodeswere cancerous.” OnFebruary1st , Michelle hadherfinal test,acolonoscopy, inwhichthree polypswere removed,andaninflammatorycolonissue knownas diverticulitis wasalso identified. Michelle thenprogressedthroughtreatmentwithacombinationof chemotherapyand milagrooil. She initiallydilutedthe cannabisoil withhempseedoil,until eventuallyshe wastakingpure, unadulteratedcannabisoil. She hadfourchemotherapysessions,the lastof whichwasApril 5th ,2012. She finishedhercannabisoil treatmentonMay16th . Throughouthertreatment,Michelle experiencedcomplications fromchemotherapy,suchas nauseaand foodtastingstrange. Eventually,evendrinkingwaterburnedhermouth. Itwasnot until the beginningof Julythatshe couldeatproperlyagain. Thankfully,anApril 17th CT scan showedthe tumor hadreduced50%, and the lymphnodeswere significantlyreducedaswell. The scanalso showed the diverticulitis haddisappeared. AsMichellestated,“Chemodoesnottouchdiverticulitis…ithadto be the oil thathealedit.” On May 10th , Michelle receivedaPETscan, whichreported“virtuallycompleteresolutionof the tumor”. OnMay 18th , Michelle’ssurgeon,Dr.PeterAnastassiou,removedsixlymphnodesandthe 2.5cm remainsof the tumor,whichactuallywasjustdeadcancer tissue. Michelle furtherendured
  53. 53. 53 complicationsfromthe surgeryandhadto remaininthe hospital,butwasfinallydischargedMay31st . Michelle reportsthatina conversationwithDr.Anastassiou,he saidhe had“neverseenlungcancer totallyeradicatedbychemo,muchlessinfourmonths.” Michelle believesitwascannabisoil thatmade the difference. ThroughoutJune,Michellerecoveredfromherordeal,andinJulyshe begantosteadily recoverenergyandappetite. Michelle finishedthe articlewiththe followingstatement: “I trulybelieve thatif itwasn’tforValerie andthe oil Iwouldnotbe alive today. EverydayI read about people dyingof cancerandI knowI was able to heal mybodyof cancer. Why is thishealth-givingplant not available toeveryone? Peopleshouldnothave togo throughthe sufferingthatcancerbrings. We needtoget thisinformationouttothe world. Cannabisisa healingplantandcan evenheal cancerif we letit.” An interviewwithMichelleaboutherexperience canbe foundhere: http://www.youtube.com/watch?v=9AZU-brG7i4 Mark Pedersenof CannabisPatientNetworkrecordedanexperiencewithJeremyKigar,ahospital dietician (https://www.youtube.com/watch?v=CJ-V-2RvSr8). Jeremy discussedhisexperience taking cannabisoil fora Grade IV astrocytomaof the cerebellum. Afterdiagnosis,he wasquickly startedon16 medications,includingantibiotics,antidepressants,narcotics,andmore. Afterlearningaboutcannabis oil,Jeremystartedbytakinga half grama day forthree weeks. Withinfivedays,significantchangeshad beenobservedinhisoverallwellness. Pharmaceuticalswere reduced,including eradication of opiates and antidepressants. Jeremyhasdeniedfurtherchemotherapyandusescannabisoil in90-daycycles, whichhas hiscancer undercontrol. Accordingtothe videodescription,itwasonlyafterbeginninghigh- THC cannabisoil that Jeremy’stumorbegantoshrink. Atthe time of filming,the tumorhasreduced fromGrade IV to Grade II.
  54. 54. 54 A videofeaturingClarkFrench,anactivist withNORMLUK, describeshow cannabis oil made amassive difference to hismultiplesclerosis (http://www.youtube.com/watch?v=kdI8sGPia5s). He wentto Californiaforfour-and-a-half months,where he obtainedamedicinal cannabisrecommendationand begantakingcannabisoil. The treatmentwasincrediblyeffective –he no longerneedsawalkingstick and feelssomuchbetterthanbefore. In January2014, ClarkappearedonSkyNews,a UK newsorganization,todiscusscannabislegalization. He continuestouse cannabisashis onlymedication andcontinuestobe independentof wheelchairs and walkingsticks(http://www.youtube.com/watch?v=6dU5mRIrYUw). AnotherMS patient,Marcel Gignac, usedcannabisextractsto recoveralmostcompletely (http://medireview.com/2014/01/why-ms-patient-marcel-gignac-needs-30-grams-of-medical- marijuana-every-day). Hisformof the disease wasespeciallysevere,andMarcel enduredhundredsof medical teststryingtogetan official diagnosis. From2008 to 2013, hisconditioncontinuedtoworsen,
  55. 55. 55 althoughsmokingcannabisandsurgeryhelpedbriefly. Atone point,doctorssaidhe wouldn’tlastuntil Christmas2011. He survivedwell pastthatpoint,andinMarch 2013 decidedtoincrease hiscannabis intake insteadof takingmore narcotics. Thisincrease consistedof takingamixture of hempseedoil withpure cannabisextractand liquidVitaminD,whichquicklyresultedinhisconditionimproving. To the present,he continuestogetbetter. Asthe article states,“Evenwheneverydoctortoldhimhe wouldnotsurvive,Gignacdefiedthe oddsthankstomarijuana. Now he wantseveryone toknow his story.” Marcel isalsostudyingNeuropharmacologyatMIT to learnmore aboutthe science of cannabinoidsatthe cellularlevel. PeterGermainrecountedhis powerful experience of overcomingType IIdiabetesandobesitywiththe use of cannabis oil inan August2012 video(http://www.youtube.com/watch?v=2v76PwzYr3w). His transformationwasremarkable. Withinayear,hisdiabetes andweightwere completelyundercontrol.
  56. 56. 56 At the CannabisOil CuresCancerConcert,an event designed topromote the healingeffectsof oil,Amy Jo Clarkrecountedherhealingstory. She wasdiagnosedwithabraintumor,andin the absence of pharmaceuticalstreatedherselfwithcannabisoil. The turnaroundwasremarkable,andbloodwork takenjusta fewweeksaftertreatmentindicatednocancermarkers. Moreover,Amy’sphysical conditionandqualityof life improveddramatically. A May 2013 videodetailsEliasCooper’sexperiencewithoil forthe treatmentof chroniclymphocytic leukemia(https://www.youtube.com/watch?v=HU46L_nNKXM). Once diagnosedwithCLL,Elias desperatelywantedtoavoidchemotherapy,asitsoundedscarytogo through. His doctors saidas long as hiswhite bloodcell countremainedunderacertainlevel,theycouldpostpone chemotherapy. Elias didn’ttake anyspecial measurestocounterthe canceruntil hiswhite bloodcell countgothighenough to where chemotherapywasbecominganoption. Itwasthenalternative methodswere researched, and Eliascame upon the storyof Brave Mykayla,discussedabove. The storywascompellingenoughfor
  57. 57. 57 himto try cannabisoil. Afterthree anda half weeksof takinghomemade cannabisoileveryday, producedbyhiswife Debra,Eliaswenttothe doctor for a bloodtest. Hiswhite bloodcell counthad dropped40,000, whichwas “life changingnews”. Noothertreatments,includingchemotherapyor pharmaceuticals,were used. While hiscase isnotcompletely resolvedyet, Eliassayshe absolutelydoes not see chemotherapyinhisfuture,anditisclear the cannabisoil ishavinga positive effect. Eliasprovidedanupdate onNovember17th ,2013 (https://www.youtube.com/watch?v=QTPoc_xSlnw). Interestingly,the detailsof hiscase correlate stronglywiththe studyin CaseReportsin Oncology (summarizedinthe OverviewofSupportingScience section),whichalsoinvolvedaleukemiapatient. As Eliasdescribes,hisbloodcountwentupduringtimeshe wasnotusing cannabis oil or wasusingless potentoil,butwhenhe againprocuredhigh-qualityhigh-THCoil,the countfell dramatically. Inthe journal case,the patientalso experienced increasesanddecreasesincancercell levelsunder similar circumstances. Forexample,whendosingwaslimitedtotwice aday,the patient’sleukemicblastcount rose slightly,butthenfell backdownsharplyafterdosingreturnedtothree timesaday.
  58. 58. 58 A January2014 story ona Croationnewsstationdetailedthe storyof a38 yearoldman, referredtoas Mark forconfidentiallyreasons,fightingnon-small celllungcancer (http://www.youtube.com/watch?v=DVTkSKBeET4).He wasgivenfourtosix monthsto live,witha maximumof twelve monthsif fortunate. Mark initiallyusedchemotherapyandradiation,whichlefthim ina state that “youcan notevencall human.” His face was destroyed,hisupperlipswollen,tissuewas fallingoff hisfingers,andhisskinwasoverlysoft. The painwasespeciallydevastating,andthree timesa day,Mark thoughtof killinghimself. Despitethe barrage of conventionaltreatments,afurthermedical checkrevealedthe cancerhaddoubled. Afterthe news,Markstoppedthe treatmentsandbeganusing cannabisoil. He immediatelybeganfeelingbetter,andearlierpainsdisappeared.A monthinto treatment,Mark beganspittingout sizable amountsdarkmatterwhichwasconfirmedascancerous. Afterthree months,the cancerwasno longervisible onX-rays. Debbie Wilson’sexperiencewithcannabisextractsformultipletraumaticbraininjuriesillustratesthe benefitsof cannabinoidsforbrainhealing. Herstoryis extensively detailedinanarticle writtenbythe author (http://www.medicaljane.com/2014/02/24/the-story-of-debbie-wilson-how-cannabis-helped- her-treat-trauma-induced-epilepsy/). Epilepsy,dementia,migraines,pain,anddepressionwere Debbie’smainsymptoms,andforover20 yearsshe battledthese conditions. Itwasnotuntil 2010 that Debbie foundsignificantrelief insmokedmedicinalcannabis,whichstoppedherdiarrhea,stabilizedher bloodsugarand serotoninlevels,andreducedherseizuresandmigraines. Mostrecently,whenDebbie beganusinghigh-cannabidiol andTHC-acidtincture,herimprovementshave becomeevenmore dramatic,includingcessationof all five typesof seizuresshe experiencedbefore. A recentFacebook postfurtherdescribesthe incredibleprogress.
  59. 59. 59 Spencerisa youngchildwhowas diagnosedwithdiffusepilocyticastrocytomainFebruary2013, after large tumorson the pineal gland,brainstem, andspine were foundinaJanuarydoctor’svisit. These detailsandthose followingare fromthe author’sconversationwithSpencer’smother,Suzetta. The radiologistgave Spencertwoweekstolive withoutsurgery,ortwomonthswithit. The radiologist’s reportsaidthe case was challengingtointerpretbecause Spencer’sbiopsytissue showedmarkersfor multiple typesof cancersof differentgrades. Inlate March, Spencerstarted the carboplatinand vincristine chemotherapeuticagents,whichhadhorrificside effects,includinganear-fatal allergic reactiononMay 20, 2013. In June,Spencergota legal medicinal cannabisrecommendation. His doctorssaid he was terminal inmid-July,andrecommendednofurthertraditional treatment. Itwas aroundthenSpencerbeganhigh-CBDoil (althoughitstillcontainedasizable amountof THCas well), whichhe usedfromJune until August. The oil hasdrasticallyimprovedSpencer’smobility, andhe is evenmovinghisarmsagain,whichdoctorssaidwas impossible becauseof priornerve damage. An October2013 MRI showedreductioninthe pineal glandandspine tumors,althoughothertumors remainedstagnant. However,leptomeningialdisease in the liningof Spencer’sbrainandspine disappeared. Since then,Spencerhascontinuouslyimprovedinall of hissymptoms,includingtumor size andmobility. Hisstorycan be followedat https://www.facebook.com/prayersforspencerjames516.
  60. 60. 60 As of May 27th , 2014, Spenceriscontinuingtoimprove. A particularlyhigh-profilecase ongoinginSouthAfricaisthatof Mario Oriani-Ambrosini,aMemberof Parliament. Mariowasdiagnosed withterminalStage IV lungcancerinMay 2013 (http://www.iol.co.za/news/politics/ill-mp-to-introduce-dagga-bill-1.1649727). He denied chemotherapyinfavorof cannabisoil andbicarbonate of soda,anotheralternative cancertherapy,after beingtoldhe wouldn’tmake ittoChristmas2013. Mario haswell-outlivedhisprognosisandis feeling generallywell. Due tohispersonal successandhisbelief thatothersshouldhave the same opportunity, he has introducedabill legalizingthe medicinal andindustrialuse of cannabis. Marioalsowantsto set up a researchcenterforcannabisextracts,to determine the extentof the medicine’seffectiveness. Speakingtothe National AssemblyandPresidentJacobZuma,Mariomade an impassionedpleato decriminalize medicinal cannabis.“Iwastouchedto see the manI’ve knownandworkedwithformore than 20 yearsinthiscondition.I’ve askedthe ministerof healthtolookintothismatter,”President Jacob Zumasaid (http://www.iol.co.za/news/politics/zuma-notes-mp-s-call-for-medicinal-dagga- 1.1650592).
  61. 61. 61 A furtherarticle aboutthe cannabisextractsituationinSouthAfricaopenedwithaquote fromLindsey Martin, a Cape Town motherwhotreatedherself for coloncancerwithoil (http://www.iol.co.za/news/politics/clamour-for-medical-marijuana-1.1651195).“There is nodoubt aboutit. My aggressive cancerisgone…the same cancer thatwas supposedtokill me inmonths.Iam alive todaybecause of cannabisoil.” Anotherpatient,amanwithMS namedGerdBader,saidhe was losingconsciousnessandclose todeathbefore usingextracts. Aftercannabistreatment,he sayshe has no more symptomsof MS, althoughsome mobilityissuesapparentlyremain. Experienceslikethese have ledthe CancerAssociationof SouthAfricatosupportthe developmentof cannabisextract medicines,aslongas theyare registeredwiththe properauthorities.
  62. 62. 62 A personal lettersentfromapatienttothe blogMedical Marijuana411 detailstheirexperience of using ShonaBanda’svaporizationtechniquetoproduce oil and overcome severe symptomsof Crohn’sdisease (http://medicalmarijuana411.com/mmj411_v3/shona-banda-saved-my-life/).The writernotesthere is still more healingtogo,andprogressseemstohave beeninhibitedbyaninabilitytomake larger quantitiesof oil. Grow Goddess,whowasinitiallymentionedinthisreportasbeingJoe Crowe’scaregiver, describedhowshe came tostart producingoil andtreatingpatientsina poston HempOilHope.org (http://hempoilhope.org/viewtopic.php?f=5&t=124). She mentionsJoe’scase,aswell asa gout patient whoexperiencedconcrete successwithonlyafew dosesof oil. Grow Goddessstated, “Anotherpatient I have encounteredhassevere gout.He tookonlyafew dosesof the oil,andthe gout literally disappearedfromhisknuckles.Three monthslater,withouttakinganymore oil,the gouthadnot returnedtohisknucklesandthe gout onthe restof hisbodyisstill visible,butthe swellingwasreduced a bit.If he wentthroughthe full treatment,Ibelieve the goutwouldbe completelygone.” A November2012 post onthe forumGrassCity.comdetailedaman’streatmentof hiswife with self-madecannabisoil formetastaticbreastcancer (http://forum.grasscity.com/medical-marijuana- usage-applications/1130359-tumors-really-shrinking.html). The wife,givensix monthstolive after abandoningchemotherapyandradiation,begancannabisoil asanalternative. Withinthree days,she was able toeat again;her excruciatingheadachescompletelydisappeared,andshe begantolookbetter overall. Atthe time of the post,anothertestconductedby the oncologistconfirmedthe tumorswere actuallyshrinking. Interestingly,the manwasgiveninformationabout“RickSimpsonOil”fromGranny Storm Crow,the individualmentionedabove inthe OverviewofSupportingScience section who compiledandorganizedanextensivelistof studiesoncannabis.

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