Immunogenetics

1. Immunogenetics

2. Learning Objectives
• By the end of this lecture……….we all should
be able:
– To appreciate the organization of immune system
– Understand the disorders related to immune
system
– Explain the underlying mechanisms of immune
disorders

4. Role of immune system and their
applications

5. Innate and Adaptive imunity

6. Primary and Secondary Response

7. B and T Cells

8. Memory Cells

9. Macrophage development

10. Complement Proteins

11. Cytokines

12. Cytokines

13. Immunoglobulins
• Papaine splits the immunoglobulin
molecule into three fragments.
– Two similar, each containing an
antibody site capable of combining
with a specific antigen antigen-
binding fragment or Fab
– The Crystallizable fragment Fc
The immunoglobulin molecule is made up of four polypeptide
chains:
•Two light(L) 220 AA
•Two heavy (H) 440 AA
Each Fab fragment is composed of L chains linked to the amino-terminal portion
of the H chains,
Fc fragment is composed only of the carboxv-terminal portion of the H chain

14. Immunoglobulins

15. Immunoglobulins

16. A Closer look at structure

17. Genetics of antibody formation
Basis of Diversity

18. Genetics of Antibody formation
A closer look

19. Class switching

20. Antibody mediated diseases

21. Immune complex diseases

22. T Cell Mediated Diseases

23. HLA Associated Diseases
Locus of genes that encode for proteins on the surface of cells that are responsible for
regulation of the immune system in humans.

24. Deficiency Diseases

25. Thank you!