Immunity BDS Lecture Sem IV

1. Immunity

2. Learning Objectives
• By the end of this lecture……….we all should
be able:
– To appreciate the organization of immune system
– Understand the disorders related to immune
system
– Explain the underlying mechanisms of immune
disorders

4. Functions of Immune System

5. Innate and Adaptive imunity

7. Primary and Secondary Response

8. B and T Cells

9. Memory Cells

10. Macrophage development

11. Complement Proteins

12. Immunoglobulins
• Papaine splits the immunoglobulin
molecule into three fragments.
– Two similar, each containing an
antibody site capable of combining
with a specific antigen antigen-
binding fragment or Fab
– The Crystallizable fragment Fc
The immunoglobulin molecule is made up of four polypeptide
chains:
•Two light(L) 220 AA
•Two heavy (H) 440 AA
Each Fab fragment is composed of L chains linked to the amino-terminal portion
of the H chains,
Fc fragment is composed only of the carboxv-terminal portion of the H chain

13. Immunoglobulins

14. Antibody mediated diseases

15. Immune complex diseases

16. T Cell Mediated Diseases

17. Thank you!