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Cell Wall & Protein Synthesis Inhibitors: Mechanisms & Resistance

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Yahya Noori, Ph.D
Yahya Noori, Ph.D

BDS Semester III

Health & Medicine
1 of 19
Inhibitors of Cell wall and Protein Synthesis BDS Semester III
Objectives • By the end of this lecture you should be able to: • Classify the major cell wall and protein synthesis inhibitors • Understand their mechanism of action. • Explain resistance mechanisms against these antimicrobials.
Carbapenems
Limitations of Penicillins • Limited effectiveness against many gram negative rods • Hydrolysis by gastric acid • Inactivation by beta- lactamases • Hypersensitivity reactions
Carbapenems •Monobactam
1. Aminoglycosides 2. Tetracyclins Inhibition of Protein Syntesis 1. Chloramphenicol 2. Erythromycin 3. Clindamycin 4. Linezolid 5. Streptogramins
Cell Wall & Protein Synthesis Inhibitors: Mechanisms & Resistance
Cell Wall & Protein Synthesis Inhibitors: Mechanisms & Resistance
Cell Wall & Protein Synthesis Inhibitors: Mechanisms & Resistance
Cell Wall & Protein Synthesis Inhibitors: Mechanisms & Resistance
Cell Wall & Protein Synthesis Inhibitors: Mechanisms & Resistance

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