Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.
Cell Wall Synthesis Inhibitors
Dr.Reshmi.T.R
Bacterial Cell Wall
 Cell wall-Stability
 Composed of Peptidoglycan layer
Peptidoglycan layerParallel polysaccharide
glycan chains crosslinked by peptide chains
Prevents lysis and death of bacter...
Pentapeptide side chain
L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine
NAcM
L-Ala
D-Glu
L-Lys
D-ALa
D-Ala
 Pentaglycine
bridge extends
from L-lysine
residue of one
peptide chain to
D-alanine
residue of
another
NAG
NA
G
Transpeptidation Reaction
 Process of cross bridging
 Catalysed by enzymes Penicillin Binding
Proteins(PBPs)
 Provide s...
NAG
UDP
NAM UDP
Enolpyruvate
transferase
NAG
UDP
NAM UDP
L-LysD-GluL-Ala
L-Ala
D-Glu
NAM UDP
L-Lys
NAM
UD
P
NAM
UD
P
L Alanine D- Alanine
Racemace
Ligase
P PP
UMP N
A
G
UDP
UDP
PP
N
A
G
PP
N
A
G
N
A
G
N
A
G
N
A
G
N
A
G
N
A
G
N
A
G
N
A
G
N
A
G
N
A
G
Transpeptidase
Cell Wall Synthesis Inhibitors
Fosfomycin
Cycloserine
Bacitracin
Vancomycin
Beta Lactams
Anti TB drugs
Isoniazid
Ethambuto...
NAG
UDP
NAM UDP
Enolpyruvate
transferase
NAG
UDP
Fosfomycin
NAG
UDP
NAM UDP
Enolpyruvate
transferase
NAG
UDP
Fosfomycin
NAM
UD
P
NAM
UD
P
Cycloserine
L Alanine D- Alanine
Racemace
Ligase
P PP
UMP N
A
G
UDP
PP
UDP
N
A
G
PP
N
A
G
Bacitracin
N
A
G
N
A
G Vancomycin
N
A
G
N
A
G
N
A
G
N
A
G
N
A
G
N
A
G
N
A
G
TranspeptidaseBeta Lactams
Mycobacterial cell wall
Peptidoglycan+ Mycolic acid+ Arabinogalactan(AG)
Isoniazid
Inhibit mycolic acid which is
an essential component of
mycobacterial cell wall
Ethambutol
 Inhibit arabinosyl transferase enzyme
prevent polymerisation of
arabinogalactans, an essential
component of ...
Pyrazinamide
Inhibit mycolic acid which is an
essential component of
mycobacterial cell wall
Fungal cell wall
 Glucans(major)+ Chitin+ Mannins
Echinocandins
Inhibit synthesis of 1,3-beta –glucan,an
essential component of fungal cell wall lysis
of cell wall
Cell wall synthesis inhibitors
Cell wall synthesis inhibitors
Upcoming SlideShare
Loading in …5
×

Cell wall synthesis inhibitors

2,082 views

Published on

Cell wall synthesis Inhibitors

Published in: Health & Medicine

Cell wall synthesis inhibitors

  1. 1. Cell Wall Synthesis Inhibitors Dr.Reshmi.T.R
  2. 2. Bacterial Cell Wall  Cell wall-Stability  Composed of Peptidoglycan layer
  3. 3. Peptidoglycan layerParallel polysaccharide glycan chains crosslinked by peptide chains Prevents lysis and death of bacteria
  4. 4. Pentapeptide side chain L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine NAcM L-Ala D-Glu L-Lys D-ALa D-Ala
  5. 5.  Pentaglycine bridge extends from L-lysine residue of one peptide chain to D-alanine residue of another NAG NA G
  6. 6. Transpeptidation Reaction  Process of cross bridging  Catalysed by enzymes Penicillin Binding Proteins(PBPs)  Provide strength to bacteria
  7. 7. NAG UDP NAM UDP Enolpyruvate transferase NAG UDP
  8. 8. NAM UDP L-LysD-GluL-Ala L-Ala D-Glu NAM UDP L-Lys
  9. 9. NAM UD P NAM UD P L Alanine D- Alanine Racemace Ligase
  10. 10. P PP UMP N A G UDP UDP PP N A G PP N A G N A G N A G
  11. 11. N A G N A G N A G N A G N A G N A G N A G Transpeptidase
  12. 12. Cell Wall Synthesis Inhibitors Fosfomycin Cycloserine Bacitracin Vancomycin Beta Lactams Anti TB drugs Isoniazid Ethambutol Pyrazinamide Anti fungal Drugs Echinocandins
  13. 13. NAG UDP NAM UDP Enolpyruvate transferase NAG UDP Fosfomycin
  14. 14. NAG UDP NAM UDP Enolpyruvate transferase NAG UDP Fosfomycin
  15. 15. NAM UD P NAM UD P Cycloserine L Alanine D- Alanine Racemace Ligase
  16. 16. P PP UMP N A G UDP PP UDP N A G PP N A G Bacitracin N A G N A G Vancomycin
  17. 17. N A G N A G N A G N A G N A G N A G N A G TranspeptidaseBeta Lactams
  18. 18. Mycobacterial cell wall Peptidoglycan+ Mycolic acid+ Arabinogalactan(AG)
  19. 19. Isoniazid Inhibit mycolic acid which is an essential component of mycobacterial cell wall
  20. 20. Ethambutol  Inhibit arabinosyl transferase enzyme prevent polymerisation of arabinogalactans, an essential component of mycobacterial cell wall
  21. 21. Pyrazinamide Inhibit mycolic acid which is an essential component of mycobacterial cell wall
  22. 22. Fungal cell wall  Glucans(major)+ Chitin+ Mannins
  23. 23. Echinocandins Inhibit synthesis of 1,3-beta –glucan,an essential component of fungal cell wall lysis of cell wall

×