Artificial Intelligence In Microbiology by Dr. Prince C P
ADRENAL INCDIENTALOMA
1. Adrenal incidentaloma and its
management
Presented by-Dr Yajnadatta Sarangi
Guided by–Dr Pradeep Garg(Sr.Prof & unit head )
2. A clinically unapparent mass detected
incidentally by imaging studies conducted for
other reasons.
There existence as a clinical entity is a
byproduct of advanced medical imaging.
3. epidemiology
Incidentaloma- 8% of autopsies
-1-4% of abdominal imaging studies.
Incidental adrenal mass increases with age with less than
.5% risk below 25 year of age and up to 7% in more than
75 year of age.
20% of incidentaloma -potential surgical lesions
4. Classification
IN PATIENT WITH HISTORY Of IN PATIENT WITHOUT HISTORY
MALIGNANT DISEASE MALIGNANT DISEASE
metastatic disease(2%)
Non funcionig adenomas(75%)
pheochromocytoma(4%)
cortisol producing adenoma(7%)
adrenocortical carcinoma(4%)
adrenal cyst(2%)
ganglioneuroma
myeolipoma(2%)
conns adenoma(1%)
5. In patient with a history of malignant disease, metastatic disease is the most
likely cause of adrenal mass, particularly when they are bilateral .
In 80% case incidentaloma- nonfunctioning cortical lesions.
Adrenal metastases are likely in patients with a history of cancer elsewhere
Metastsis are generally from- renal cell carcinoma, melanoma, lung cancer,
colon cancer, and lymphoma.
8. History
Hypertension, obesity, glucose intolerance -Cushing syndrome
Headache ,palpitation ,perfuse sweating-pheochromocytoma
Significant hypertension with hypokalemia-aldosterone producing adenoma
History of malignancy –metastasis
History of familial condition-pheochromocytoma
10. Hormonal evaluation
10% of adrenal incidentalomas -metabolically active.
All adrenal incidentalomas demand a metabolic evaluation whether symptomatic
or not.
Annual follow-up for 3 to 4 years is recommended for metabolically silent masses
11. Hormonal Evaluation
Morning And Midnight Plasma Cortisol Measurements;
A 1-mg Overnight Dexamethasone Suppression Test;
24-hour Urinary Cortisol Excretion(2 times)
Salivary cortisol(2 times)(convenient now days, OPD basis)
serum cortisol(adrenal insufficiency)
ACTH level
24-hour Urinary Excretion Of Catecholamines, Metanephrines Or;
Plasma Aldosterone And Plasma Renin Activity;
Serum DHEAS, Testosterone Or 17β-hydroxy Estradiol (Virilizing Or
Feminizing Tumor).
12. Contd…
High dose dexamethasone suppression test
24 hour free urinary aldosterone level
13. IMAGING
Ultrasound –not much helpful as adrenal so far from
body surface
left adrenal gland -not visualized by ultrasound.
CECT performed in all patient with adrenal mass.
CECT underestimate the tumour size by approx. by
20%
Size, laterality, homogenecity, vascularity, density and
anatomic relationship can be accurately assessed
14. UNENHANCED AND ENHANCED CT
Adenomas being lipid rich, an adrenal lesion measuring less than 10
HU an adenoma 100% of cases regardless of the size.
Lipid poor adenomas can measure between 10 and 20 HU, in these
cases contrast scans are used and enhancement is measured at 60 s
and 15 min. Absolute washout of contrast at 15 min (> 95% ) is lipid
poor adenoma .
Masses >6 cm should be considered malignant until proved otherwise.
15. Character suggestive of benign lesion on ct-
Well defined border
High lipid content
Low vascularity
Rapid washout of contrast
16. Character in CT suggesting of malignancy
Ill defined border
Necrosis
Internal calcification
17. MRI
Based on Chemical shift
The lipid content of adenoma causes signal dropout on MRI.
30% of adrenal adenomas do not showing signal dropout on MRI.
MRI is largely diagnostically equivalent to non-contrast CT as
both are equally capable in quantifying intracellular lipid.
MRI angiography is useful to exclude tumor thrombus in the
vena cava, which must be excluded before adrenalectomy
More expensive and not superior on contrast CT
18.
19. FDG PET
Highly sensitive and specific to distinguish between
benign and malignant lesion
Can't distinguish between adrenocortical carcinoma
and metastasis
20. Metaiodobenzylguanidine (MIBG) scan
MIBG is an analogue of noradrenaline and it
selective uptake by chromaffin cells in the
adrenal (phaeochromocytoma) or extra-adrenal
locations.
MIBG may be helpful in diagnosing and
localising recurrent,metastatic,multifocal
phaeochromocytoma in difficult locations.
21. Adrenal venous sampling
Done in patienty
With-unilateral mass suspicious of
aldosteronoma and contralateral side cant
be ruled out
Age >40 year
Aldosterone/cortisol ratio observed
Laterization confirm aldosteronoma
22. FNAC
Only in patient with history of extra adrenal malignant disease to confirm
metastasis
rule out pheochromocytoma
23. Role of Adrenal biopsy
THE ROLE FOR ADRENAL BIOPSY HAS BEEN LIMITED FOR THE FOLLOWING REASONS:
Modern imaging affords super diagnostic capabilities.
Histologically adenomas cannot be reliably differentiated from adrenal
carcinomas.
Adrenal biopsy is not without risk.
Never biopsy an adrenal mass until pheochromocytoma has been
biochemically excluded
The indication for adrenal gland biopsy-- adrenal gland metastasis.
28. Surgical Indications for
Adrenalectomy
Functional adrenal mass ( Cortisol hypersecretion,
Pheochromocytoma, Aldosterone hypersecretion)
Mass > 4 cm with exception of myelolipoma
Mass with imaging findings that are suggestive of
malignancy (lipid-poor, heterogeneous, irregular
borders, infiltrates surrounding structures, )
29. Surgical indication contd.
Adrenal incidentaloma that grow greater than 1 cm on
follow-up imaging.
Extremely large and/or symptomatic myelolipoma.
isolated adrenal metastasis
ACTH-independent macronodular adrenal
hyperplasia(primary adrenal cushing syndrome)
Incidentaoma(3-4cm)-patients preference,if patient
wish to avoid the burden of surveillance
30. Surgical indication contd.
DURING RADICAL NEPHRECTOMY FOR RENAL CELL CARCINOMA IF:
Adrenal abnormal or not visualized due to large renal tumor size on imaging.
Large (≥7 cm) upper pole mass.
Vein thrombus to level of adrenal vein
31. aldosteronoma
Unilateral laparoscopic adrenalectomy is an effective therapy in patients with clear
evidence of unilateral or asymmetrical bilateral disease.
A subtotal resection is favoured in the case of a typical Conn’s adenoma
32. Cortisol producing adenoma(cushings
adenoma
A unilateral adenoma is treated by adrenalectomy.
In cases of bilateral ACTH-independent disease , bilateral
adrenalectomy is the primary treatment.
ectopic ACTH-dependent Cushing’s syndrome ,an irresectable
or unlocalised primary tumour and failure of TSPS should be
considered for bilateral adrenalectomy as this controls
hormone excess.
Subclinical(no sign and symptoms) Cushing’s syndrome
caused by unilateral adenoma is treated by unilateral
adrenalectomy.
33. Adenocortical carcinoma
ACC represent- 2% of adrenal tumour measuring 4cm or smaller
6% of adrenal tumour measuring >4cm
Complete tumour resection (R0) is associated with favourable survival and should
be attempted whenever possible.
In order to prevent tumour spillage and implantation metastases, the capsule must
not be damaged.
En bloc resection preferred if invading organs
Laparoscopic adrenalectomy is associated with a high incidence of local recurrence
and NOT recommended.
Tumour debulking plays a role in functioning tumours to control hormone
excess.
Chemotheapy-adjuvant setting,unresectble tumour,metastatic tumour
Chemo agent-mitotone,cisplatin,doxorubicin,,etoposide
34. Adjuvant radiotherapy -educe the rate of local recurrence.
restaging every 3 months
Prognosis depends on the stage of disease(mcferlane
classification) and complete removal of the tumour.
Patients with stage I or II disease have a 5-year survival rate of
25% whereas patients with stage III and stage IV disease have 5-
year survival rates of 6% and 0% respectively.
42. OPEN SURGERY
Indications for Open Surgery
Adrenal cortical carcinoma.
the extension of adrenal vein tumor thrombus into the
inferior vena cava
Tumour > 8 cm(some consider >5-6 cm).
Malignant pheochromocytoma
Clinical feminization present(almost all feminizing tumors are
malignant)
43. Open surgery contd.
Adrenal glands are located deep in upper abdominal cavity.
Glands are equidistant from all ipsilateral body surfaces, necessitating large
open incisions regardless of point of entry.
Open adrenalectomy can be performed through either a transperitoneal or
retroperitoneal approach.
1. The transperitoneal approaches include midline, subcostal, and
thoracoabdominal.
2. The retroperitoneal approaches include flank and posterior
lumbodorsal.
The advantages of the transperitoneal approaches are better exposure for
larger tumors and excellent access to the great vessels and retroperitoneum.
The main disadvantages are prolonged ileus and difficult exposure in morbidly
obese patients.
48. ROBOTIC SURGERY
The advantages of robotics should be the superior three-dimension visualization
and hand-like ability of the robotic arms to perform the microdissection of the
plane between the adrenal and the great vessels.
The robotic approach has the disadvantage of increased expense and limited
availability compared to standard laparoscopy.
49. SURGICAL PRINCIPALS
Minimal manipulation of adrenal mass.
Dissection should in the surrounding tissues away
from adrenal glands ( N0 touch technique).
Ligation of adrenal arteries.
Ligation of adrenal vein be careful at the right side
as vein is short and drain posteriorly directly in IVC
and difficult to control if torn during dissection
called vein of death.