Overview of Discussion- Definition of Autocoid Classification of Autocoids

1. Mr. Vishal Balakrushna Jadhav
Assistant professor (Pharmacology)
School of Pharmaceutical Sciences (SOPS), Sandip University, Nashik
Introduction to autocoids and classification
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2. Overview of Discussion
 Definition of Autocoid
 Classification of Autocoids
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3. Definition of Autocoid
 The term is derived from Greek: autos- self, akos- healing substance
or remedy.
 Are Diverse substances produced by a wide variety of cells in the
body, having intense biological activity, generally act locally (e.g.
within inflammatory pockets) at the site of synthesis and release.
 Are chemical agents/ substances produced in our body and show
their important physiological functions on other organs or tissues,
and thus helps to protect our body in some adverse situation.
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4.  Involved in a number of physiological and pathological processes
(especially reaction to injury and immunological insult). The
functions of autacoids are: Microcirculation, Drug reaction, Allergic
reaction, Inflammation, Anaphylaxis-severe allergic reaction.
 Also been called ‘local hormones’. Differ from ‘hormones’ in two
important ways- hormones are produced by specific cells, and are
transported through circulation to act on distant target tissues.
 Some autacoids, in addition, serve as transmitters or modulators in
the nervous system, but their role at many sites is not precisely
known.
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5. Classification of Autocoids
Autocoids are classified as-
 Amine autacoids Histamine, 5-Hydroxytryptamine (Serotonin)
 Lipid derived autacoids Prostaglandins, Leukotrienes, Platelet
activating factor
 Peptide autacoids Plasma kinins (Bradykinin, Kallidin), Angiotensin
In addition, cytokines (interleukins, TNFα, GM-CSF, etc.) and several
peptides like gastrin, somatostatin, vasoactive intestinal peptide and
many others may be considered as autacoids.
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6. Thank You
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Questions
are
entertained….