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Ceritifcate of Attendance, 2nd
WHO-IUMSP International Seminar on the Public Health
Aspects of Noncommunicable Diseases, University of Lausanne, Switzerland
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Certificate, Fellowship in Diabetes and Endocrinology
University of Newcastle Upon Tyne, United Kingdom
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Ph.D. (Exercise Physiology), Wollongong University, Australia
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B.Sc. („µ¥£µ¡Îµ´—) ¤®µª·š¥µ¨´¥¤®·—¨
Certificate, Human Thermoregulatory Research, University Wollongong, Australia
Certificate, Biomedical Instrument, Purdue University, Indiana, USA
Certificate, Chest Physical Therapy, New York University, USA
Certificate, Spinal Orthosis, New York University, USA
Certificate, Lower Limb Prosthesis, New York University, USA
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Ph.D. (Food, Nutrition and Dietetics)
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M.Sc.(Human Nutrition)
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Diplomate (Community Nutrition), University of Indonesia, Indonesia
Ceritifcate, Nutrition Epidemiology and Statistics, University of Queensland, Australia
Certificate, International Visitor’s Programme of the North Karelia Project
National Public Health Institute, Helsinki, Finland
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Ph.D. (Epidemiology) University of North Carolina at Chapel Hill, USA
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Diplomate, American Board of Internal Medicine
Diplomate, Subspecialty Board of Endocrinology and Metabolism
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Certificate, Fellowship in Nutrition Support and Obesity Medicine
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Certificate, Research Fellow in Human Nutrition, South Western Medical Center
Dallas, Texas, USA
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Vocational Education, UTS, Australia
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15. 6
Á°„µ¦°oµŠ°·Š
1. Lee SY, Gallagher D. Assessment methods in human body composition. Curr Opin Clin
Nutr Metab Care. 2008; 11: 566-72.
2. Global data base on Body Mass Index.
http://apps.who.int/bmi/index.jsp?introPage=intro_5.html
3. Aekplakorn W, Pakpeankitwatana V, Lee CMY, et al. Abdominal obesity and coronary
heart disease in Thai men. Obesity 2007; 15: 1036-42.
4. WHO/IASO/IOTF. The Asia-Pacific perspective: redefining obesity and its treatment.
Health Communications Australia: Melbourne.
5. Šnµ —µ¤µ¡Š¬r, ¨´——µ Á®¤µ³»ª¦¦–, »œš¦¸ ¦´˜œ¼Á°„. ‡ªµ¤Áž}œ¤µÂ¨³ž{®µÃ¦‡°oªœÄœÁ—È„.
Äœ: 懰oªœÄœÁ—È„: ÂœªšµŠžj°Š„´œ —¼Â¨¦´„¬µ ¨³¢gœ¢¼. »¦·¥Á—ª š¦·žµ˜¸, »œš¦¸ ¦´˜œ¼Á°„,
¦¦–µ›·„µ¦. ™µ´œ»…£µ¡Á—Ȅ®nŠµ˜·¤®µ¦µ·œ¸ „¦¤„µ¦Â¡š¥r „¦³š¦ªŠµ›µ¦–»….
´¥Á‹¦·, „¦»ŠÁš¡¤®µœ‡¦ 2551: 1-17.
6. Onat A, Avci GS, Barlan MM, Uyarel H, Uzunlar B, Sansoy V. Measures of abdominal
obesity assessed for visceral adiposity and relation to coronary risk. Int J Obes Relat
Metab Disord 2004; 28:1018-25.
7. Alberti KG, Eckel RH, Grundy SM, et al. Harmonizing the metabolic syndrome: a joint
interim statement of the International Diabetes Federation Task Force on Epidemiology
and Prevention; National Heart, Lung, and Blood Institute; American Heart Association;
World Heart Federation; International Atherosclerosis Society; and International
Association for the Study of Obesity. Circulation 2009; 120: 1640-5.
8. ÂœªšµŠÁªž’·´˜·„µ¦žj°Š„´œÂ¨³—¼Â¨¦´„¬µÃ¦‡°oªœ ™µ´œª·‹´¥Â¨³ž¦³Á¤·œÁš‡ÃœÃ¨¥¸šµŠ
„µ¦Â¡š¥r „¦¤„µ¦Â¡š¥r „¦³š¦ªŠµ›µ¦–»…. »¤œ»¤®„¦–r„µ¦Á„¬˜¦Â®nŠž¦³Áš«Åš¥ 2553.
9. Aekplakorn W, Pakpeankitwatana V, Lee CMY, et al. Abdominal obesity and coronary
heart disease in Thai men. Obesity 2007; 15: 1036-42.
10. Janssen I, Kartzmarzyk PT, Ross R. Waist circumference and not body mass index
explains obesity-related health risk. Am J Clin Nutr 2004; 79: 379-84.
11. Aekplakorn W, Cheepudomwit S, Bunnag P, et al. A risk score for predicting incident
diabetes in the Thai population. Diabetes Care 2006; 29: 1872-7.
12. Kolditz CI, Langin D. Adipose tissue lipolysis. Curr Opin Clin Nutr Metab Care 2010; 13:
377-81.
13. De Feo P, Di Loreto C, Lucidi P, et al. Metabolic response to exercise. J Endocrinol Invest
2003; 26: 851-4.
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14. Borer KT, Wuorinen E, Ku K, Burant C. Appetite responds to changes in meal content,
whereas ghrelin, leptin, and insulin track changes in energy availability. J Clin Endocrinol
Metab 2009; 94: 2290-8.
15. Klaus S. Adipose tissue as a regulator of energy balance. Curr Drug Targets 2004; 5: 241-
50.
16. Cypess AM, Kahn CR. The role and importance of brown adipose tissue in energy
homeostasis. Curr Opin Pediatr 2010; 22: 478-84.
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Engl J Med 2009; 360: 1518-25.
18. Hansen JC, Gilman AP, Odland JØ. Is thermogenesis a significant causal factor in
preventing the "globesity" epidemic? Med Hypotheses 2010; 75: 250-6.
19. Blouin K, Boivin A, Tchernof A. Androgens and body fat distribution. J Steroid Biochem
Mol Biol 2008; 108: 272-80.
20. Traish AM, Guay A, Feeley R, Saad F. The dark side of testosterone deficiency: I.
metabolic syndrome and erectile dysfunction. J Androl 2009; 30: 10-22.
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22. Molenaar EA, Massaro JM, Jacques PF, et al. Association of lifestyle factors with
abdominal subcutaneous and visceral adiposity: the Framingham Heart Study. Diabetes
Care 2009; 32: 505-10.
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abdominal fat in blood donors. Rev Saude Publica 2008; 42: 1067-73.
24. Pravdova E, Macho L, Fickova M. Alcohol intake modifies leptin, adiponectin and resistin
serum levels and their mRNA expressions in adipose tissue of rats. Endocr Regul 2009;
43: 117-25.
25. Risérus U, Ingelsson E. Alcohol intake, insulin resistance, and abdominal obesity in elderly
men. Obesity 2007; 15: 1766-73.
26. Du H, van der A DL, Boshuizen HC, et al. Dietary fiber and subsequent changes in body
weight and waist circumference in European men and women. Am J Clin Nutr 2010; 91:
329-36.
27. Romaguera D, Angquist L, Du H, et al. Dietary determinants of changes in waist
circumference adjusted for body mass index - a proxy measure of visceral adiposity. PLoS
One 2010; 5(7): e11588.
17. 8
28. Malik VS, Popkin BM, Bray GA, Després JP, Willett WC, Hu FB. Sugar-sweetened
beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes
Care 2010; 33: 2477-83.
29. Fung TT, Malik V, Rexrode KM, Manson JE, Willet WC, Hu FB. Sweetened beverage
consumption and risk of coronary heart disease in women. Am J Clin Nutr 2009; 89: 1037-
42.
30. Stanhope KL, Schwarz JM, Keim NL, et al. Consuming fructose-sweetened, not glucose-
sweetened, beverages increases visceral adiposity and lipids and decreases insulin
sensitivity in overweight/obese humans. J Clin Invest 2009; 119: 1322-34.
31. Koster A, Leitzmann MF, Schatzkin A, et al. The combined relations of adiposity and
smoking on mortality. Am J Clin Nutr 2008; 88: 1206-12.
32. Caks T, Kos M. Body shape, body size and cigarette smoking relationships. Int J Public
Health 2009; 54: 35-9.
33. Chouraki V, Wagner A, Ferrières J, et al. Smoking habits, waist circumference and
coronary artery disease risk relationship: the PRIME study. Eur J Cardiovasc Prev Rehabil
2008; 15: 625-30.
34. Fawcett KA, Barroso I. The genetics of obesity: FTO leads the way. Trends Genet 2010;
26: 266-74.
24. 15
»…£µ¡¦³—´ž{‹Á‹„ (individual approach) Å—o„n„µ¦ž¦´Áž¨¸É¥œ¡§˜·„¦¦¤…°Šž¦³µœÄœÁ¦ºÉ°Š„µ¦
„·œ°µ®µ¦š¸ÉÁ®¤µ³¤ ¨³nŠÁ¦·¤Ä®o¤¸„·‹„¦¦¤šµŠ„µ¥š¸ÉÁ¡¸¥Š¡°‹¹ŠÁž}œ·ÉŠš¸É˜o°Š—εÁœ·œ„µ¦Ä®o¤¸‡ªµ¤
Á…o¤Šª—¤µ„…¹Êœ˜n°Åž
Á°„µ¦°oµŠ°·Š
1. http://iotf.org/database/documents/GlobalPrevalenceofAdultObesity20thJanuary2010.pdf
2. Global data base on Body Mass Index.
http://apps.who.int/bmi/index.jsp?introPage=intro_5.html
3. WHO/IASO/IOTF. The Asia-Pacific perspective: redefining obesity and its treatment.
Health Communications Australia: Melbourne.
4. Aekplakorn W, Mo-Suwan L. Prevalence of obesity in Thailand. Obes Rev. 2009; 10: 589-
92.
5. Aekplakorn W, Hogan MC, Chongsuvivatwong V, Tatsanavivat P, Chariyalertsak S,
Boonthum A, Tiptaradol S, Lim SS. Trends in obesity and associations with education and
urban or rural residence in Thailand. Obesity (Silver Spring) 2007; 15: 3113-21.
6. ª·´¥ Á°„¡¨µ„¦ (¦¦–µ›·„µ¦). ¦µ¥Šµœ„µ¦Îµ¦ª‹»…£µ¡ž¦³µœÅš¥Ã—¥„µ¦˜¦ª‹¦nµŠ„µ¥
‡¦´ÊŠš¸É 4 ¡.«. 2551-2552. œœš»¦¸: εœ´„ŠµœÎµ¦ª‹»…£µ¡ž¦³µœÅš¥ / ™µ´œª·‹´¥¦³
µ›µ¦–»…; 2553.
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Gene Model Tissue
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weight
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intake
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expenditure
Leptin
Leptin receptor
MC4 receptor
MC3 receptor
Melanin concentrating hormone (MCH)
GPR7
Perilipin
ASP (C3)
Neuropeptides B and W
Acetyl CoA Carboxylase
NO synthase
PKA RII beta
Beta adrenergic receptor
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Cidea
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UPC1-/-
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×¥¡ªnµ¡¸Éœo°Š˜nµŠµ¥Á¨º°—š¸É°µ¥»Ä„¨oÁ‡¸¥Š„´œ ¨³™¼„Á¨¸Ê¥Š¤µ—oª¥„´œ˜´ÊŠÂ˜nÁ¨È„Ç ‹³¤¸—´œ¸¤ª¨„µ¥
Ä„¨oÁ‡¸¥Š„´œ šÎµÄ®o‡·—ªnµÃ¦‡°oªœš¸É¦³µ—°¥¼nÄœž{‹‹»´œÁž}œŸ¨‹µ„ž’·´¤¡´œ›r¦³®ªnµŠž{‹‹´¥šµŠ
·ÉŠÂª—¨o°¤Â¨³¡§˜·„¦¦¤„´‡ªµ¤Á¸É¥Š‹µ„šµŠ¡´œ›»„¦¦¤25
ž{‹‹»´œ¤¸¥¸œš¸É´¤¡´œ›r„´Ã¦‡°oªœ (genetic syndrome associated with obesity) ×¥šÎµÄ®o¤¸
¨´„¬–³ÁŒ¡µ³…°ŠÃ¦‡¤µ„„ªnµ 25 ¥¸œ Ánœ Prader Willi, Aistrom, Bardet-Biedl ¨³°ºÉœÇ ¨³¤¸
nonsyndromic forms of obesity ‹µ„‡ªµ¤Ÿ·—ž„˜·…°Š¥¸œ Lep, LepR, MC4R, POMC ¨³°ºÉœÇ ˜n
¡ªnµ‡ªµ¤Ÿ·—ž„˜·…°Š¥¸œ˜´ªÄ—˜´ª®œ¹ÉŠ Áž}œµÁ®˜»nªœœo°¥…°Š„µ¦Á„·—懰oªœÁšnµœ´Êœ
懚µŠ¡´œ›»„¦¦¤š¸É´¤¡´œ›r„´Ã¦‡°oªœ26, 27
µ¤µ¦™ÂnŠÅ—oÁž}œ 2 „¨»n¤ ‡º°
1. 懰oªœ„¦¦¤¡´œ›»rš¸É¡¦nª¤„´„µ¦¡´•œµ„µ¦oµ„ªnµª´¥ (Obesity associated with
development delay)
2. 懰oªœ„¦¦¤¡´œ›»rš¸ÉŤn¤¸‡ªµ¤Ÿ·—ž„˜·…°Š„µ¦¡´•œµ„µ¦˜µ¤ª´¥ (Obesity not associated
with development delay)
30. 21
˜µ¦µŠš¸É 2. —ŠÁ„–”r„µ¦ª·œ·‹Œ´¥Ã¦‡ Prader-Willi syndrome
Diagnostic criteria for Prader-Willi syndrome
Major criteria
x Neonatal and infantile hypotonia, with poor suck and subsequent improvement with age
x Feeding problems with poor weight gain in infancy, needing gavage or other special feeding
techniques
x Weight gain (rapid onset 1 to 6 years old) that leads to central obesity
x Characteristic facial features, including narrow bifrontal diameter, almond-shaped palpebral fissures,
and turned-down mouth
x Hypogonadism/hypogenistalism: genital hypoplasia (small labia minora and clitoris in females, and
hypoplastic scrotum in males); incomplete and delayed puberty; and infertility
x Developmental delay/mild to moderate mental retardation/multiple learning disabilities
x Hyperphagia/obsession with food
x Chromosome 15q11-q13 abnormality
Minor criteria
x Reduced fetal movement and infantile lethargy, which improves with age
x Characteristic behavioral problems, including temper tantrums, obsessive-compulsive behavior,
stubbornness, rigidity, stealing, and lying
x Sleep disturbance or apnea
x Short stature for family by 15 years of age
x Hypopigmentation
x Small hands and feet for height and age
x Narrow hands with straight ulnar border
x Eye abnormalities, including esotropis and myopia
x Thick viscous saliva
x Speech articulation defect
x Skin picking
Additional features
x High pain threshold
x Decreased vomiting
x Altered temperature sensitivity
x Scoliosis and kyphosis
x Early adrenarche
x Osteoporosis
x Unusual skill with jigsaws
x Normal neuromuscular studies (e.g., muscle biopsy and electromyography)
36. 27
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„µ¦¤¸„·‹„¦¦¤šµŠ„µ¥¨—¨Š „µ¦Š—»®¦¸É ¥µµŠœ·— ¦nª¤„´‡ªµ¤Ÿ·—ž„˜·šµŠ„¦¦¤¡´œ›»r ¤¸Ÿ¨Ä®o
¡¨´ŠŠµœš¸É„·œ¤µ„„ªnµ¡¨´ŠŠµœš¸É¦nµŠ„µ¥œÎµÅžÄo Á„·—¡¨´ŠŠµœ³¤Äœ¦¼ž…°ŠÅ…¤´œÄœ¦nµŠ„µ¥ ‹œÁž}œ
µÁ®˜»Ä®oÁ„·—æ‡Âš¦„Žo°œ˜nµŠÇ ˜µ¤¤µ
Á°„µ¦°oµŠ°·Š
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