2. R C
OH
H
H R C
O
H
R C
O
OH
Alcohol Aldehyde Carboxylic
Acid
What is an Aldehyde?
3. Manufacturing the Chemical Reducing Reagent (CRR)
• Can be made by a two step Synthesis
• The First Step is Carried out at Ambient Temperature
• The second Step is Carried out at 60C
7. Ingredients For Manufacturing Aldehydes
Esters
Made by Reaction of Alcohols with Organic Acids
Can be Purchased and/or Manufactured
Chemical Reducing Reagent (CRR)
Manufacturing process is Trade Secret
Can Only be Produced by Aldehydes, Inc.
8. Chemistry of Manufacturing Aldehydes
• Reaction of Esters with CRR to form Aldehydes
• RCOOR’ + CRR = RHO (Aldehyde) + Oxidized CRR
• Four Hour Reaction in a Refluxing Solvent
• Refluxing Solvent Removed by Distillation
• Aldehyde Easily Separated from Oxidized CRR by Solvent Extraction
• Extraction Solvent Removed by Distillation
9. Manufacturing Progress
• To Date: We have Manufactured Aldehydes on a Small Scale
• ½ to 1 Pound Lots
• High Yields (95%+)
• High Purity (98%+)
• Analyzed by Proton NMR
• Proton NMR is the Accepted Method for Identifying Aldehydes
and Determining its Purity
• Accepted in Pharmaceutical Industry
10. Examples of Aldehydes Produced to Date
• 4-Oxobutanoic Acid monohydrate
• (2E)-4-Oxobut-2-enoic Acid
• (2Z)-4-Oxobut-2-enoic acid
• Ethyl 3-Oxopropanoate
Can Custom Synthesize Aldehydes to Suite your Needs
11. Advantages of Process
• CRR is Relatively Inexpensive to Produce
• Aldehyde Reactions are Carried Out under Mild Conditions
• Avoids Unwanted By-products
• Results in High Purity and Excellent Yield
• CRR is inert to other Chemical Groups
• Specifically Reacts with Esters to Form only Aldehydes
• Allows us to Make Complex Aldehydes
• Other Processes use Severe Conditions
• Resulting in unwanted By-products that are Difficult to Separate from Aldehydes
• Creating:
• Poor Yields
• Low Purity
• Reagents of other Processes React with Other Chemical Functional Groups
• Limiting these Processes to Making Only Simple Aldehydes
12. Disadvantages of Process
• Possible Theft of Confidential Intellectual Property
• Patenting Could Result in Infringement
13. Competition And Marketing
• Aldehydes are in Demand Because they Participate in Many Chemical Reactions
• They are used Particularly in the Pharmaceutical, Perfume and Plastic industries
• They can also be sold to Chemical Supply Houses
• Because of Their Reactivity Most of Them are Difficult to Make
• The Complex Aldehydes that we Manufacture either do not Exist or are Available at
High Cost
• This Leads to Little or no Competition
• Only one other Chemical Reducing Reagent Exist that can Convert Esters to
Aldehydes, it is Diisobutyl Aluminum Hydride
• It has to be Stored in a Pressurize Inert Atmosphere making it Difficult to
Handle
• It is More Expensive than out CRR
• It will reduce Esters to Alcohols
14. Environment Factors
• Mild Conditions using Minimum Amounts of Energy
• Little of no Unwanted By-products
• No Toxic Metals
• By-product of CRR Manufacturing is Environmentally Friendly