cirrhosis

1. cirrhosis

2. Alcoholic hepatitis
• 60-80 g/d
• Fatty liver
1. Abnormal LFT
2. Large liver

3. • Alcoholic hepatitis
1. Jaundice
2. Hepatomegaly
3. Portal HTN
Pathology
1. Balloning degeneratiobn
2. Neutophill infiltration
3. Mallory bodies
4. Some fibrosis
Mallory bodies
1. Non alcoholic liver disease
2. Alcoholic liver disease
3. Wilsosn disease
4. Primary bilary cirhosis
5. HCC
Composed of intermediate filaments

4. • Cirrhosis
1. Large/smalal/normal size
2. Portal HTN
3. HCC
• Stigmata
Pathology-cirhosis
1. Fibrosis-laennac

5. lab
• Anemia
• Nutritional
• Bone marrow suppression
• Hemolytic anemia –Zieve syndrome
• Increase Tg ,PT,Bilurubin
• AST>ALT

6. Treatment
• Pentoxyfilline-non specific TNF inhibitor (reduce mortality
• Steroids
• Acamprosate – abstinace from alcohol

7. Lille score
• assess tx response to steroid in alcoholic hepatitis
• 6 variable
1. Age
2. Renal insufficieanvcy
3. Albumin
4. PT
5. Bilurubin
6. Evolution bilirubin in a day