Viral hepatitis

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Tess Jose

neet notes

Health & Medicine

Hep A
• Feco oral route
• m/c cause of epidemic in children in India
• Picorna
• Passiv eimmunisation – human Ig

Hep B
• Via inoculation sexual ,vertical transmission
• Occur at time of delivery
• Risk is 90 % if mother is positive
• Serum , semen, saliva ++++
• Not in stool
• Prevalence +++
Downs , leprematous leprosy , leukemias , Hodgkin , PAN , hemodialysis
, IV abusers

• Window period : disappearance of antigen and appearance of
antibodies.
• Sexual B>>>C
• Vertiacl B>>>C

Active immunisation 0,1,6 months IM
• Health workers
• Haemodialysis patient
• Iv abusers
• Homosexual
• Hemophillias
Pregnancy is not contraindication

• Post exposur propylaxis
• Perinatal exposure : HBIG 0.5 ML f/b 3 dose of vaccine within 12
hours of life
• Needle stick injury : HBIG (0.06/KG) f/b 3 dosesof vaccine within 1
week
• Sexual contact :HBIG (0.06/KG) f/b 3 dosesof vaccine within 2week

HEP C
• Via inoculation sexual ,vertical transmission
• Chronicity

HEP D
• Via inoculation sexual ,vertical transmission

HEP E
• FECO ORAL
• Non parenteral hepatitis
• Fatality maximum in pregnancy
• M/c epidemics in India

HEP G
• FLAVI VIRUS
• HGV Infection reducer liver fibrosis in HIV Patients

ACUTE VIRAL HEPATITIS
• PATHO
• Pan lobular injfiltartion with mono nuclear cells
• Hepatic cell necrosis
• Hyperplasia of kupper cells
• Ballooning of cells
• Acidophillic degeneration
• Councilman bodies
• Bridging necrosis ( severe )

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