The slide contains all the relevant information required for D. pharm students regarding Sulphonamides as prescribed under Bangalore university. Hope it helps!

1. SULPHONAMIDES
PRESENTED BY SWEETY GUPTA(B PHARM)

2. SULPHONAMIDES

3. SULPHONAMIDES
• Stability and storage conditions-
• Affected by heat and light and the presence of air and moisture accelerates
the effect. Hence, they are stored in tightly closed, light resistant
containers.

4. SULPHADIAZINE
• Physical properties-
• White crystalline powder.
• Odorless
• Very slightly soluble in water.
• Tasteless.

5. SULPHADIAZINE
• Chemical properties-
• Diazotization reaction-

6. SULPHADIAZINE
• Identification test- Sulphadiazine+ 0.1N NaOH+1%CuSO4 soln, Purple
brown ppt seen.

7. SULPHADIAZINE
• Antibacterial agents.
• Meningitis.
• UTI
• Toxoplasmosis.

8. SULPHAGUANIDINE (SULFA-GWANI-DEEN)
• Physical properties-
• White crystalline powder.
• Odorless
• Very slightly soluble in water.
• Tasteless.

9. SULPHAGUANIDINE (SULFA-GWANI-DEEN)
• Chemical properties-

10. SULPHAGUANIDINE (SULFA-GWANI-DEEN)
• Identification test- Sulphaguanidine+ 0.1N NaOH+1%CuSO4 soln, blue ppt
seen.

11. SULPHAGUANIDINE (SULFA-GWANI-DEEN)
• Uses-
• Antibacterial .
• Local intestinal infections like bacillary dysentery.

12. SULPHAGUANIDINE (SULFA-GWANI-DEEN)
• Popular brand names- Ganidan, Guanimycin, Entrogen

13. SUCCINYLSULPHATHIAZOLE (SUXI-NILE-SULFA-THIAZOLE)
• Physical properties and chemical properties-
• White crystalline powder.
• Odorless
• Very slightly soluble in water.
• Slightly bitter taste.

14. SUCCINYLSULPHATHIAZOLE (SUXI-NILE-SULFA-THIAZOLE)
• Uses-
• Antibacterial.
• Treatment of bacillary dysentery.
• To reduce bacterial flora of large intestine before surgery.

15. SUCCINYLSULPHATHIAZOLE(SUXI-NILE-SULFA-THIAZOLE)
• Popular brand names- SS thiazole, Cremostep, Cremomycin, Sulphamycin.

16. PHTHALYLSULPHATHAIZOLE (Thalile-sulfa-thiazole)
• Physical properties-
• White crystalline powder.
• Very slightly soluble in water.
• Slightly bitter taste.

17. PHTHALYLSULPHATHAIZOLE (Thalile-sulfa-thiazole)
• Chemical properties-
• Diazotisation reaction to form Di-azo compound.
• Phthalylsulphathaizole + 0.1N NaOH + 1% CuSO4 solution = Green colored
ppt.
• Phthalylsulphathaizole + Resorcinol + Conc. Sulphuric acid + aq. NaOH
solution = Green fluroscence is seen.

18. PHTHALYLSULPHATHAIZOLE (Thalile-sulfa-thiazole)
• Uses-
• Antibacterial.
• Treatment of bacillary dysentry.
• Reduce bacterial flora of the large intestine before surgery.

19. PHTHALYLSULPHATHAIZOLE (Thalile-sulfa-thiazole)
• Popular brand names- Colcidina,Talidina

20. Sulphadimethoxine (Sulfa-Dye-Methoxine)
• Physical properties-
• White powder.
• Tasteless.

21. Sulphadimethoxine (Sulfa-Dye-Methoxine)
• Chemical properties-
• Diazotization reaction.
• Sulphadimethoxine + 1%CuSO4+ 0.1N NaOH solution = Green fluorescence
is seen.

22. Sulphadimethoxine (Sulfa-Dye-Methoxine)
• Uses-
• Antibacterial
• Treatment of UTI.

23. Sulphadimethoxine (Sulfa-Dye-Methoxine)
• Popular brand names- Bensulfa, Sulfadren, K-prim

24. Sulphamethoxypyridazine (Sulfa-methoxy-pirida-zeen)
• Physical properties-
• White powder
• Slight bitter taste

25. Sulphamethoxypyridazine (Sulfa-methoxy-pirida-zeen)
• Chemical properties-
• Diazotisation reaction.
• Sulphamethoxypyridazine + 0.1N NaOH + 1% CuSO4 + = Greenish brown
colored ppt is seen.

26. Sulphamethoxypyridazine (Sulfa-methoxy-pirida-zeen)
• Uses-
• Antibacterial.
• Treatment of UTI.

27. Sulphamethoxypyridazine (Sulfa-methoxy-pirida-zeen)
• Popular brand names- Dyrasul, Confin

28. Co-trimoxazole (Ko-Trim- Oxazole)
• 5 parts of Sulphamethoxazole and 1 Part of trimethoprim.
• Physical and chemical properties-
• White to yellowish powder.
• Odorless.
• Bitter taste.
• Slightly soluble in water.

29. Co-trimoxazole (Ko-Trim- Oxazole)
• Uses-
• Antibacterial.
• Treatment of UTI.
• Treatment of meningitis.
• Treatment of enteric infections.

30. Co-trimoxazole (Ko-Trim- Oxazole)
• Popular brand names- Bactrim, Septra, Ciplin, Uritrim.

31. Sulphacetamide (sulfa-setamide)
• Physical properties-
• Acidic and saline taste.

32. Sulphacetamide (sulfa-setamide)
• Chemical properties-
• Diazotization reaction.
• Sulphacetamide + 0.1N NaOH + 1% CuSO4 = Blue coloured ppt.

33. Sulphacetamide (sulfa-setamide)
• N acetyl p-aminobenzene
sulphonamide.

34. Sulphacetamide (sulfa-setamide)
• Uses-
• Antibacterial.
• Locally to treat eye infections.
• Systemically to treat UTI

35. Sulphacetamide (sulfa-setamide)
• Brand names-
• Albucid, Locula, Ne-Ba-Sulf, Eycula

36. Assignment Questions-
1. Describe chemistry and nomenclature of sulphonamides.
2. Write structure, chemical name, physical properties, chemical properties,
uses, brand names and stability storage conditions for Sulphacetamide.
3. Write physical properties, chemical properties, uses, brand names and
stability storage conditions for Sulphaguanidine and sulphamethoxamine.
4. Write physical properties, chemical properties, uses, brand names and
stability storage conditions for Succinylsulphathiazole and
sulphamethoxamine.

37. END OFTHIS CHAPTER
• Submit this assignment on or before 10/11/2020.
• Thank you one and all.