2. ANAESTHESIA
Term coined by American physician Oliver Wendell Holmes in 1846
Derived from Greek words: an-without and anaesthesia-sensation
Natural substances like alcohol, opium, cannabis were used previously that
resulted into high mortality due to shock, pain and blood loss
3. As per records,
1540- Paracelsus administered ether to chicken
1800- Nitrous oxide was recognized but wasn’t successfully used
Henry Hill Hickman administered CO2 to experimental animal
1842- Ether was used in human
4. 1845- Horace Wells used Nitrous oxide to relive dental pain but
had failure
1846-William Morton gave demonstration of use of diethyl ether
as surgical anaesthesia
1847-James Simpson introduced chloroform
5. 1875-First IV technique by using chloral hydrate
1884- Cocaine was used as local anaesthesia
1898- First spinal anaesthesia was described
1929-Cyclopropane was used as general anaesthetic
6. 1930s – Development of barbiturate (pentobarbitone) by J.W
Wright
1934- Thiopentone developed
1956- Introduction of halothane
