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How meta-analysis
advances knowledge
Stephen S Holden
Risks of eating bacon?
• colorectal cancer
risk +18% risk /
50g of processed
meat / day
• overall risk = 1 in
17 = 5.8%
Risks of eating bacon?
5.8%
6.9%
0%
2%
4%
6%
8%
No bacon 50g / day
% risk cancer
Theory of Signal Detection (TSD)
Noise Signal
Dangers of NHST
Hit ! False alarm
Miss
Correct
rejection
Effect No effect
Think so
Think not
Overlooking effect sizes
“I’ve heard it before”…
…belies the uncertainty of science
Open Science Collaboration Science 2015;349:aac4716
The price of oversight
• The Reproducibility
Project
• p-hacking
Advancing knowledge
Theatre of theory
• top-down
• theoretical
• ideas
• hypothetico-deductive
• NHST
Empire of empirical
• bottom-up
• empirical
• data
• fishing trip
• effects
Effect size measures
• absolute measures
• correlational
• r, R2, eta-sq
• differences
• SMDs, Cohen’s d, Hedge’s g
• categorical: odds-ratio, relative-risk
• raw-mean score differences
• relative measures
• % change, elasticities
Sales
SoM
Choice
Purchase
Consump’n
Learning
Memory
Perception
- - - -
Motivation
Beliefs
Attitudes
Intentions
Psychology Behavior Outcome
Advertising
Cons’r bhvr
Channels
Pricing
NPD
Sales
Strategy
Interventions
Chain of effect
Effect of attitudes on behaviour?
• r=.5
• k=128, N=4,598
• Glasman & Albarracin (2006)
• stronger when
• attitudes are more accessible
• direct experience and/or reported frequently
• attitudes are more stable over time
• confident, based on bhvr relevant information, one-sided info
Effect of anti-depressants?
• Cohen’s d < .2
• for HDRS < 23 (mild or moderate), placebo vs ADM (anti-depressant
medication)
• HDRS scale runs 0 to 52
• pax treated with ADMs average 2 points higher on HDRS than
placebo!
• statistical significance vs clinical significance
• https://www.scientificamerican.com/article/antidepressants-do-
they-work-or-dont-they/
SMD
Standardized
Mean
Differences
Cohen’s
d
Pearson’s
r
“small” .3 .1
“medium” .5 .3
“large” .8 .5
Cohen 1992 “A power primer”
Effect of anti-depressants
Effect of advertising on sales
• advtg elasticity = .12
• ie, a 10% increase in advertising  1.2%
increase in sales
• price elasticity = -2.3
• ie, a 10% increase in price  23% reduction
in sales
• banner click-through-rate (CTR)
• .3 to .05% (PWC report)
Effect of portion-size on obesity?
• effect on behaviour
• d = .45
• elasticity = .35
• effect on weight
• .56kg/mo
Effect of health supplements
Meta-meta-analysis of advance in
knowledge
• 176 meta-analyses
• >7,500 primary studies (43 studies per meta-analysis)
published between 1918 and 2012
• >54,000 effect sizes (307 effect sizes per meta-analysis)
• sample of 8,337,096 subjects (based on primary studies of 131
meta-analyses)
• Eisend 2015 JM
Meta-meta-analytic effect sizes
Corr (r) r2
All effect sizes .24 5.6%
Advertising .21 4.6%
Channels .24 5.7%
Consumer behaviour .28 8.1%
Method .15 2.4%
New product development .20 4.1%
Pricing .36 13.0%
Sales .23 5.2%
Strategy .25 6.1%
Advancing knowledge
Theatre of theory
• top-down
• theoretical
• ideas
• hypothetico-deductive
• NHST
Empire of empirical
• bottom-up
• empirical
• data
• fishing trip
• effects
It’s not the end
of the world if
you’re wrong !
How meta-analysis has
helped to advance
knowledge
Stephen S Holden
• research designs
• preferential treatment of experiments (RCT)
• selection bias
• file drawer
• publication bias
• heterogeneity / moderator analyses
• non-random sample of domain
• fixed vs random effects
• collinearity
Contentious issues

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How meta-analysis advances knowledge

  • 2. Risks of eating bacon? • colorectal cancer risk +18% risk / 50g of processed meat / day • overall risk = 1 in 17 = 5.8%
  • 3. Risks of eating bacon? 5.8% 6.9% 0% 2% 4% 6% 8% No bacon 50g / day % risk cancer
  • 4.
  • 5. Theory of Signal Detection (TSD) Noise Signal
  • 6. Dangers of NHST Hit ! False alarm Miss Correct rejection Effect No effect Think so Think not
  • 7. Overlooking effect sizes “I’ve heard it before”… …belies the uncertainty of science
  • 8. Open Science Collaboration Science 2015;349:aac4716 The price of oversight • The Reproducibility Project • p-hacking
  • 9. Advancing knowledge Theatre of theory • top-down • theoretical • ideas • hypothetico-deductive • NHST Empire of empirical • bottom-up • empirical • data • fishing trip • effects
  • 10. Effect size measures • absolute measures • correlational • r, R2, eta-sq • differences • SMDs, Cohen’s d, Hedge’s g • categorical: odds-ratio, relative-risk • raw-mean score differences • relative measures • % change, elasticities
  • 11. Sales SoM Choice Purchase Consump’n Learning Memory Perception - - - - Motivation Beliefs Attitudes Intentions Psychology Behavior Outcome Advertising Cons’r bhvr Channels Pricing NPD Sales Strategy Interventions Chain of effect
  • 12. Effect of attitudes on behaviour? • r=.5 • k=128, N=4,598 • Glasman & Albarracin (2006) • stronger when • attitudes are more accessible • direct experience and/or reported frequently • attitudes are more stable over time • confident, based on bhvr relevant information, one-sided info
  • 13. Effect of anti-depressants? • Cohen’s d < .2 • for HDRS < 23 (mild or moderate), placebo vs ADM (anti-depressant medication) • HDRS scale runs 0 to 52 • pax treated with ADMs average 2 points higher on HDRS than placebo! • statistical significance vs clinical significance • https://www.scientificamerican.com/article/antidepressants-do- they-work-or-dont-they/
  • 16. Effect of advertising on sales • advtg elasticity = .12 • ie, a 10% increase in advertising  1.2% increase in sales • price elasticity = -2.3 • ie, a 10% increase in price  23% reduction in sales • banner click-through-rate (CTR) • .3 to .05% (PWC report)
  • 17. Effect of portion-size on obesity? • effect on behaviour • d = .45 • elasticity = .35 • effect on weight • .56kg/mo
  • 18. Effect of health supplements
  • 19. Meta-meta-analysis of advance in knowledge • 176 meta-analyses • >7,500 primary studies (43 studies per meta-analysis) published between 1918 and 2012 • >54,000 effect sizes (307 effect sizes per meta-analysis) • sample of 8,337,096 subjects (based on primary studies of 131 meta-analyses) • Eisend 2015 JM
  • 20. Meta-meta-analytic effect sizes Corr (r) r2 All effect sizes .24 5.6% Advertising .21 4.6% Channels .24 5.7% Consumer behaviour .28 8.1% Method .15 2.4% New product development .20 4.1% Pricing .36 13.0% Sales .23 5.2% Strategy .25 6.1%
  • 21.
  • 22.
  • 23. Advancing knowledge Theatre of theory • top-down • theoretical • ideas • hypothetico-deductive • NHST Empire of empirical • bottom-up • empirical • data • fishing trip • effects
  • 24. It’s not the end of the world if you’re wrong !
  • 25. How meta-analysis has helped to advance knowledge Stephen S Holden
  • 26. • research designs • preferential treatment of experiments (RCT) • selection bias • file drawer • publication bias • heterogeneity / moderator analyses • non-random sample of domain • fixed vs random effects • collinearity Contentious issues

Editor's Notes

  1. 10 cohort studies 5.8% risk background risk vs 6.9% risk if eating 50g of bacon a day ! +17% risk / 100g of red meat / day cf men who smoke have 20x risk of lung cancer
  2. SIMULATED 95% CIs of +/- 0.5% what does it tell us if the CIs are smaller? larger?
  3. statistically significant vs clinically (or practical) significance statistical significance is a function of sample size, p-value, and effect-size (bigger effects are more likely to be “statistically significant”)
  4. Tversky & Kahneman (1971) “Belief in the law of small numbers” Psych Bull expt n=20 generated a significant result, z=2.23, p<.05 Well (1991) “The perils of N=1” JCR Bass (1995) “Empirical generalizations in marketing science: a personal view” Mktg Science McShane & Gal (2015) “Blinding Us to the Obvious? The Effect of Statistical Training on the Evaluation of Evidence” Mgt Science NHST encouraging dichotomous view
  5. Original study effect size versus replication effect size (correlation coefficients). Diagonal line represents replication effect size equal to original effect size. Dotted line represents replication effect size of 0. Points below the dotted line were effects in the opposite direction of the original. Density plots are separated by significant (blue) and nonsignificant (red) effects.
  6. the stage is set and the play requires hypotheses, test, conclusions so we create hypotheses to explain the data - after they are collected !
  7. Hamilton Depression Rating Scale (HDRS) k=6, 718 patients
  8. breakage rate of condoms is 2% you have more chance of a condom failing than someone clicking on your banner ad! highlighting that mktrs don’t control powerful effects, but are playing in the ultimate numbers game
  9. the stage is set and the play requires hypotheses, test, conclusions so we create hypotheses to explain the data - after they are collected !
  10. Go fishing, let your suspicions run wild, choose those which have evidence, accept that there may be some false alarms