This study examined serum zinc and copper levels in 100 newborns and their mothers to determine the relationship between maternal and neonatal levels and birth outcomes. The study found that cord serum zinc levels were higher than maternal levels, while copper levels were lower. Preterm neonates had lower zinc and copper levels compared to term neonates. Fetal hypozincemia was associated with intrauterine growth restriction in preterm neonates, highlighting the importance of zinc for intrauterine growth. Several trials have shown that zinc supplementation in mothers can reduce preterm births and low birth weight.

1. STUDY OF SERUM ZINC ANDSTUDY OF SERUM ZINC AND
COPPER IN NEONATES ANDCOPPER IN NEONATES AND
THEIR MOTHERSTHEIR MOTHERS
Soumya Ranjan Parida
Basic B.Sc. Nursing 4th
year
Sum Nursing College

2. ZINCZINC
• Third most abundant trace element after
iron and fluorine.
• Most abundant intracellular metal after
potassium and calcium.
• Prosthetic group in metalloenzymes like
carbonic enhydrase and superoxide
dismutase.
• Important for body growth & development
of CNS & its myelination and bone
mineralisation of fetus.
• Synthesis of DNA & RNA.
• Helps in tissue repair and phagocytosis.

3. COPPERCOPPER
• Essential part of cuproproteins.
• Regulation of biological amines in
brain.
• Prosthetic group in tyrosinase and
superoxide dismutase.

4. AIMS AND OBJECTIVESAIMS AND OBJECTIVES
• 1.To find out level of zinc & copper in
pregnant women & their newborns at the
time of delivery.
• 2.To find out relation between maternal
serum zinc & copper status and serum
zinc,copper status of their newborns.
• 3.To find out the correlation of these
values with birth weight and gestational
age.
• 4.To find out whether deficiency of these
trace metals is associated with IUGR &

5. Material and MethodsMaterial and Methods
• The study group comprised 100 newborns
delivered in maternity ward of P.B.M.
hospital,Bikaner and their mothers and 20
nonpregnant women to act as control.
• Excluding,neonates with perinatal complication
affecting the physical & neurological status &
newborns with evident congenital malformations.
• Method-atomic absorption
spectrophotometry

6. OBSERVATIONS

7. MEAN SERUMMEAN SERUM ZINCZINC ANDAND COPPERCOPPER
LEVELS IN MATERNAL AND CORDLEVELS IN MATERNAL AND CORD
BLOODBLOOD
0
20
40
60
80
100
120
140
160
180
SERUM
ZINC
LEVEL
SERUM
COPPER
LEVEL
MATERNAL ZINC
LEVEL
CORD SERUM
ZINC LEVEL
MATERNAL
COPPER LEVEL
CORD SERUM
COPPER LEVEL

8. MEAN CORD SERUMMEAN CORD SERUM ZINCZINC ANDAND
COPPERCOPPER OF TERM AND PRETERMOF TERM AND PRETERM
NEWBORNNEWBORN
0
20
40
60
80
100
120
SERUM
ZINC
LEVEL
SERUM
COPPER
LEVEL
TERM SERUM
ZINC LEVEL
PRETERM SERUM
ZINC LEVEL
TERM SERUM
COPPER LEVEL
PRETERM SERUM
COPPER LEVEL

9. MEAN SERUMMEAN SERUM ZINCZINC ANDAND COPPERCOPPER LEVELSLEVELS
OFOF TERMTERM NEWBORNS AND THEIR MOTHERSNEWBORNS AND THEIR MOTHERS
0
20
40
60
80
100
120
140
160
SERUM
ZINC
LEVEL
SERUM
COPPER
LEVEL
MATERNAL
SERUM ZINC
LEVEL
TERM
NEWBORN
SERUM ZINC
LEVEL
MATERNAL
SERUM COPPER
LEVEL
TERM
NEWBORN
SERUM COPPER
LEVEL

10. RELATION OF CORD SERUMRELATION OF CORD SERUM ZINCZINC
ANDAND GESTATIONAL AGEGESTATIONAL AGE
0
20
40
60
80
100
120
34 WKS -40 WKS
CORDSERUMZINCLEVEL
micrograms/dl
cord serum
zinc level

11. RELATION OF CORD SERUMRELATION OF CORD SERUM ZINCZINC
ANDAND BIRTH WEIGHTBIRTH WEIGHT
0
20
40
60
80
100
120
140
BIRTH WEIGHT(kg)
CORDSERUMZINC
micrograms/dl
SERUM ZINC
LEVEL

12. RELATION OF CORD SERUMRELATION OF CORD SERUM
COPPER AND GESTATIONAL AGECOPPER AND GESTATIONAL AGE
0
5
10
15
20
25
30
35
40
30 33 36 39 42
GESTATIONAL AGE(WEEKS)
CORDSERUMCOPPER
LEVEL(microgram/dl)

13. RELATION OF CORD SERUM COPPERRELATION OF CORD SERUM COPPER
AND BIRTH WEIGHTAND BIRTH WEIGHT
0
10
20
30
40
50
60
1 1.5 2 2.5 3 3.5 4
BIRTH WEIGHT(KG)
CORDSERUM
COPPER(microgram/dl)

14. MEAN CORD SERUM ZINC LEVEL INMEAN CORD SERUM ZINC LEVEL IN
RELATION TO INTRAUTERINE GROWTHRELATION TO INTRAUTERINE GROWTH
STATUS AT TERM AND PRETERMSTATUS AT TERM AND PRETERM
0
20
40
60
80
100
120
CORDSERUMZINC
LEVEL(microgram/dl)
TERM AGA
TERM SGA
TERM LGA
PRETERM AGA
PRETERM SGA

15. MEAN CORD SERUM COPPERMEAN CORD SERUM COPPER LEVEL IN RELATIONLEVEL IN RELATION
TO INTRAUTERINE GROWTH STATUS AT TERM ANDTO INTRAUTERINE GROWTH STATUS AT TERM AND
PRETERMPRETERM
0
5
10
15
20
25
30
35
40
45
50
CORDSERUMCOPPER
LEVEL(micrograms/dl)
TERM AGA
TERM SGA
TERM LGA
PRETERM AGA
PRETERM SGA

16. CONCLUSIONCONCLUSION
• 1.Cord serum zinc level is higher than
maternal serum & copper level is lower.
• 2.Prematurity is associated with lower
cord levels of serum zinc & copper levels.
• 3.Our study has revealed that fetal
hypozincemia was associated with IUGR
in our preterm group emphasising the
importance of zinc in intrauterine growth
of fetus.
• 4.Several trials have suggested reduction
in preterm & LBW on zinc
supplementation in mother.

17. THANKS