Role of Oxidative stress in disease modification

1. A PRESENTATION ON ROLE OF OXIDATIVE
STRESS IN DISEASE MODIFICATION
Presented By :
Soobiya Majeed
Roll No. 14451S0110
M.Pharm (sem-I)
Pharmacology
SUCP
Under the guidance of:
Dr. Anupama Koneru
M.pharm, ph.D
Principal
SUCP

2. CONTENTS
1. INTRODUCTION
2. OXIDATIVE STRESS
3. FACTORS AFFECTING OXIDATIVE STRESS
4.FREE RADICALS
5.OXIDATIVE STRESS AND DISEASES
6. CONCLUSION
7. BIBLIOGRAPHY

3. OXIDATIVE STRESS
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen
species and a biological system's ability to readily detoxify the reactive intermediates or to
repair the resulting damage.

6. What are free
radicals?
Reactive oxygen species

9. Free radicals acumulate
damage
CELLS
DNA
LIPIDS SUGARS
PROTEINS
CELL MEMBRANE
DYSFUNCTION
DNA
DAMAGE
ENZYME
REACTIVATION
PROTEIN
RE-MODIFICATION
AGING DISEASES

10. OXIDATIVE STRESS AND DISEASES

11. OXIDATIVE STRESS AND PARKINSONS DISEASE
lAt the cellular level, PD is related to excess production of reactive oxygen species (ROS),
lto alterations in catecholamine metabolism, to modifications in mitochondrial electron transporte
lChain (METC) function or to enhancement of iron deposition in the SNpc.

12. OXIDATIVE STRESS AND CANCER

13. OXIDATIVE STRESS AND CARDIAC FAILURE

14. ANTIOXIDANTS
VITAMIN E
VITAMIN C
FLAVANOIDS
CHLOROPHYLL
CAROTENIODS
DISEASES

15. ANTI OXIDANTS
1.PREVENTION
2.INTERCEPTION
3.REPAIR
STOP PRODUCTION
COLLECT UNSAFE SPECIES
CONVERT TO SAFER SPECIES
FREE
RADICALS

18. CONCLUSION
Oxidative stress is considered as the major underlying cause of various diseases. It is
found that generation of reactive metabolits play a central role in cell’s life. These
metaboloites are continuously controlled by endogenous antioxidant enzyme system,
which may be enzymatic or non-enzymatic or transitional metals. Thus, the balance is
created between pro-oxidants and antioxidants. Reactivemetabolites play important
biological functions in calls in a controlled environment. The impairment of antioxidant
status, either by exogenous or endogenous sources, may disturb the cellular redox
balance and the pathological condition would be the main characteristics and forms
oxidative stress in cells and tissues. There by leading to various diseases.

19. BIBLIOGRAPHY
1.Basic and Clinical Pharmacology 12/E (Lange Basic Science)
2.Rang & Dale's pharmacology, 8th edition from Humprey Rang.
3.Essentials of medical pharmacology(jaypee) k.d. Tripathi
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Hodara R, Fredenburg R, Wu DC, Follenzi A, Dauer W, Przedborski S,
I schiropoulos H, Lansbury PT, Sulzer D,Cuervo AM. Dopamine-modified
alpha-synuclein Blocks chaperone-mediated autophagy.
5.J Clin Invest. 2008;118:777–788.
6. Lotharius J, Brundin P. Impaired dopamine storage resulting from
alpha-synuclein mutations may contribute to the pathogenesis of Parkinson's dise