The effect on consciousness of the brain in different situations: 1)after a meal 2)During Starvation 3)After a Brain Injury

1. BY: SIDDHI
Metabolism and
Consciousness

2. Table of contents
Consciousness
Brain after a meal
Brain during Fasting/Starvation
Metabolism after a brain injury

3. Alertness Orientation
Concsiousness
To place and timeBeing aware of the surroundings

4. Brain after a Meal
•Brain’s ‘on switch’ for
burning fat
•Sends signal for
browning of the fat
Brain
•Circulation of
excessive insulin
•This causes tryptophan
to move in the brain
Metabolism •Tryptophan to leads to
increased production
of serotonin and
melatonin.
•These have calming
effect n regulate sleep.
lose
Alertness
Molecular switch –protein
CRAT in hunger
processing brain cells that
regulates fat storage.

5. Obesity
 In obese people the
switch doesn’t seem to
work properly
 It gets stuck in on
position.
 So when they eat ,it
doesn’t turn off-so
energy isn’t expended.
 Dieting is recognized as
small famines in the
body.
 So brain fights to store
energy.

6. Brain during fasting
 Intermittent Fasting :
Eat within 8 hour block
leaving 16 hours of
fasting in between.
 Put the body in a state of
“ketosis”
Burning of fat releases
chemical called
ketones
Ketones trigger release
of BDNF
BDNF helps build and
strength neurons and
neural connections.
BDNF -Brain derived
neurotrophic factor.

7. Metabolism after brain injury
 Brain injury – Coma
 Coma is the most severe
level of consciousness.
 To understand patient’s
awareness along with
their likelihood of
recovery.
 Consciousness ignites as
brain activity reaches a
certain threshold
 Patients with Glucose
metabolism in the brain
above 42% of normal
cortical activity could
recover in one year.

8. Metabolism during
brain injury
The figure shows
brain glucose
metabolism as
evidenced by positron
emission tomography
with
fluorodeoxyglucose(P
ET-FDG) at rest in
patients with chronic
disorders of
consciousness.
Please notice
dramatic in brain
glucose
metabolism from full
consciousness to the
minimal conscious
persistent vegetative
states

9. Thank you!