The document discusses sodium cyanoborohydride (NaBH3CN), including its preparation from sodium borohydride and hydrogen cyanide, properties such as being a less reactive reducing agent than sodium borohydride, solubility in solvents like THF and methanol, and ability to reduce protonated aldehydes and ketones at pH 3 but not neutral aldehydes and ketones. Main applications of sodium cyanoborohydride include its use as a reducing agent in organic synthesis reactions.

1. Useful Concept to
•II M.Sc Organic Chemistry,Semester-IV
•III BSc - IIT-JAM & CU-CET
•CSIR-NET/GATE exam students

2. Out lines of the Topic
• Sodium cyanoborohydride
• Introduction
• Preparation
• Applications
• Assignment

3. Introduction
Sodium borohydride structure
1. sodium cyanoborohydride is a colourless salt
2. its chemical formula is NaBH3CN.

4. Sodium cyanoborohydride preparation
• NaBH3CN is less reactive reducing agent than sodium
borohydride due to the presence of electron withdrawing cyano
group.
• Preparation :Reaction of NaBH4 with HCN gives NaBH3CN.
• It is soluble in THF, MeOH, H2O, HMPA and DMF solvents.
• NaBH3CN cannot reduce the aldehydes (or ) ketones in neutral
condition but it reduces the protonated aldehydes and ketones
at around pH 3 .

5. Main Applications-4
B.Sateesh Kumar Lecturer in chemistry GDC(M)-Srikakulam

6. B.Sateesh Kumar Lecturer in chemistry GDC(M)-Srikakulam

7. B.Sateesh Kumar Lecturer in chemistry GDC(M)-Srikakulam

8. B.Sateesh Kumar Lecturer in chemistry GDC(M)-Srikakulam

9. Assignment-IV
1.Write a short notes on NaBH3CN.
2.Write the any 4 important applications of NaBH3CN.
3.Write the preparation & use of NaBH3CN in organic
synthesis
4.How to distinguish NaBH4 with NaBH3CN

10. Thank you