Haemoglobin and anaemia.ppt
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This document discusses haemoglobin, anaemia, and the process of erythropoiesis. It aims to estimate haemoglobin concentration in blood samples to assess patient condition and gain experience using kits. Haemoglobin synthesis and red blood cell formation are related to oxygen content in blood and can increase 6-8 folds in response to conditions like anoxia. Erythropoiesis is the synthesis of red blood cells that takes place in the bone marrow from primitive nucleated cells through mitosis and maturation. Various factors like hormones, trace metals, enzymes and coenzymes are required to produce red blood cells. Anaemia is defined as a low haemoglobin level and can be caused by excessive blood loss, increased red blood
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- 3. Introduction and principle Haemoglobin
- 4. Introduction and principle Haemoglobin
- 5. Rate of Hb Synthesis & RBCs Formation related to Oxygen content of blood O2 content Hb Syn Ex. Anoxia / Hypoxia Blood loss or Hemolysis Hb synthesis 6-8 folds Anaemia Hb synthesis
- 6. Erythropoieosis Synthesis of erythrocyte Tack place in bone marrow erythrocyte are derived from primitive nucleated cell in bone marrow by successive process of mitosis & maturation.
- 7. Factor required to manufacture RBC Varity of hormone Trace metals Enzymes Co enzymes Essential a.a e.g glycine Iron
- 9. Anemia State in which the Hb conc. in blood less than the normal level. Normal level of Hb : Man 800g =14-18g/dL Woman 600g =12-16g/dL Causes of anemia : Excessive blood loss due to bleeding rate of erythrocyte destruction (hemolytic anemia ) rate of erythrocyte production
- 10. Classification of anemia Dyshemooietic anemia Hemolytic anemia Iron deficiency anemia Megaloblas tic anemia Membrane defect Enzyme Deficiency