Acetate pathway introduction

1. Acetate pathaway.
ASST.PROF ROHIT PRADIP MALI
NGSPM COP, NASHIK.

2. Content
• Introduction
• Pathway description

3. Introduction
• It is one of the most important metabolic pathway for synthesis of
secondary Metabolites.
• The pathways start with acetyl CoA so known as acetate pathway.
• From this acetate 2 pathways are form
(i) Acetate mevalonate pathway/ Isoprenoid pathway
(ii) Acetate melonate pathway
• This pathways are starting using end product of glycolysis cycle I.e
acetyl CoA its active form of acetate.

4. Pathway description
Glycolysis
Acetate mevalonate pathway
Pyruvate
Acetyl CoA Acetate melonate pathway

5. • Acetate mevalonate pathway gives Mevalonic acid and it gives
Isoprenoids ( Steroids and Terpenoids)
• Acetate melonate pathway gives Malonyl CoA intermediate Gives
fatty acids lipids ( Fat and waxes)

6. • 1. Acetate Mevalonate Pathway/lsoprenoid pathway:Isoprenoid
represent functionally and structurallythe most diverse group
metabolite. The "biogeneticisoprene rule" is the basis for formation
of variousisoprenoid compounds such as rubber,
monoterpenes,sesquiterpenes, sterol, triterpenes,
diterpenesUniversal precursor for all isoprenoids is
Isopentenylpyrophosphate (IPP) and dimethylallyl
pyrophosphate(DMAPP) and biosynthesis of these precursor
takesplace in mavalonic acid pathway.The 5-carbon
isomersisopentenyl pyrophosphate (IPP) and
dimethylallylpyrophosphate (DMAPP) are the fundamental
buildingblocks used to synthesize key biological
isoprenoids(terpenoids) including cholesterol and other
steroids,carotenoids, saponins, and limonoids.

7. • 2 . Acetate malonate pathway- The main productsof the acetate-
malonate pathway are the fattyacids, both those primary metabolites
which occuruniversaly and the more unusual compounds with
arestricted distribution. This pathway also makes animportant
contribution to plant aliphatic and aromaticcompounds, which are
biosynthesised through theformation of polyketides

8. Thank you