Dr. Roopam Jain, Professor & Head, Dept. of Pathology & Blood Bank

1. The KIDNEY
Chronic
Glomerulonephritis
DR. ROOPAM JAIN
PROFESSOR & HEAD, PATHOLOGY

2. Chronic
Glomerulonephritis
(Synonym: End-Stage Kidney, Chronic
Kidney Disease)

3. Chronic Glomerulonephritis
• Chronic GN is the final stage of a variety of glomerular diseases which
result in irreversible impairment of renal function. Th e conditions which
may progress to chronic GN, in descending order of frequency, are as
under:
• i) Rapidly progressive GN (90%)
• ii) Membranous GN (50%)
• iii) Membranoproliferative GN (50%)
• iv) Focal segmental glomerulosclerosis (50%)
• v) IgA nephropathy (40%)
• vi) Acute post-streptococcal GN (1%). However, about 20% cases of
chronic GN are idiopathic without evidence of preceding GN of any type.

4. End-stage kidney, gross appearance of short contract kidney in CGN.
The kidney is small & contracted.
The capsule is adherent to the cortex and has diffusely granular
cortical surface.

5. End-stage kidney in chronic GN, light microscopy.
Glomerular tufts are acellular and completely hyalinised.
Blood vessels in the interstitium are hyalinised and thickened while the
interstitium shows fine fibrosis & a few chronic inflammatory cells

6. Chronic Glomerulonephritis
CLINICAL FEATURES
• The patients are usually adults
• characterised by hypertension, uraemia & progressive deterioration
of renal function
• variety of systemic manifestations of uraemia
• These patients eventually die if they do not receive a renal transplant