This document summarizes thromboxane, an eicosanoid derived from arachidonic acid that plays roles in hemostasis and vascular homeostasis. Thromboxane A2 is synthesized from arachidonic acid via the cyclooxygenase pathway and causes potent vasoconstriction, platelet aggregation, and other physiological effects. It acts through thromboxane receptors and its functions include facilitating platelet aggregation and maintaining homeostasis, though it is also implicated in pathologies like vasoconstriction. Thromboxane synthesis and activity can be inhibited by several antagonists and inhibitors.

1. Pharmacology- II
Presented By :-
Prashant Jatkar
Prashant Ingawale
Gaurav Deshpande
Yogesh Pawar

2. Topic
THROMBOXANE

3. Content
1. Introduction
2. Synthesis
3. Mechanism
4. Pathology
5. Antagonist/Inhibitors
6. Functions

4. Introduction
Thromboxanes:-
“Thromboxanes is named for its
role in clot formation.
• Thromboxane is member of family of lipid known as
eicosanoids
• “Eicosanoids – Eicosa is Greek word means
“twenty”.
• Is the collective term for oxygenated derivatives of
different 20 carbon fatty acids

5. Types of thromboxanes
• Thromboxane A2
• Thromboxane B2

6. Synthesis
Arachidonic acid
cycloxygenase
Endoperoxides
[PGG2 , PGH2]
Thromboxane
synthesis
TXA2
TXB2

7. Mechnism of action
Thromboxasne binding to a any of the
thromboxasne receptors
& show their action

8. Pathophysiological action
1] Blood vessel:- vasoconstrication
2] Platelets :- aggregation &release reaction
3] Uterus :- contraction [ in vitro]
4] Bronchi :- contraction
5]Intestine :-weak spasmogenic
6]Kidney :- vasoconstrication

9. Inhibitor

10. Functions
1] It is a vasoconstrictor & potent hypertensive
agent.
2] Facilitates platelet aggregation
3] mainten homeostatic balance in the
circulatory system with prostacyclin

11. Reference
oTherotical Book of pharmacology by
K.D.Tripathi
oTherotical Book of pharmacology by
Goodman & Gilmans
o Guided By :-
Ms. Chakorkar S.S.

12. Thank You
!!!!