HYPERLIPIDEMIC AGEMT OR HYPOLIPIDEMIC AGENT

1. MEDICINAL CHEMISTRY - ||
Presented by-:
1. Gaurav Deshpande
2. Prashant Jatkar
3. Prashant Ingawale
4. Yogesh Pawar
5. Adesh khandekar

2. Anti- Hyperlipidemic Agent
OR
Hypolipidemic

3. Reference-:
fundamental medicinal chemitry by
Gareth Thomus
Text Book of Medicinal Chemistry by
Anurekha Jain & Harun M Patel
Guided By-: Mr.R.S.Naiknaware

4. Content
• Introduction
• Classification
• SAR of Hypolipidemic drugs
• MOA of Hypolipidemic drugs
• Drug structures
• Uses

5.  Defination -: Hypolipidaemic drugs are those
which lower the level of lipids & lipoproteins
in blood

6.  HMG CoA reductase inhibitor [ statin]
E.g Lovastatin, pravastatin
 Lipoprotin lipase activator [fibrate]
E.g Clofibrate, fenofibrate
 Bile acid sequestrants
E.g 1. Cholesteramine
2. Cholestipol

7. HMG CoA Inhibitor Reductase

8. MOA OF STATIN
HMG COA Reductase enzyme is essential
for cholesterol synthesis pathway
statin
Inhibit the HMG COA reductase enzyme so
decrease cholesterol level
Statin
Anti-inflamatory effect on the blood vessel
wall
less Atherosclerosis

9. Uses
• This is first choise drug for dyslipidaemia
in diabetics
• Statin are first choise drug for primery
hyperlipidaemias with raised LDL & CH
level
• Statins reduce the risk of heart attack,
stroke & even death for heart diseases

10. Adverse effect
• Headache, nausea, bowel upset, rashes
• Rises in serum transaminase
• Myopathy Disease

11. Brand Name

13. MOA OF FIBRATE
USES
Fenofibrate is used along with a proper diet to
help lower ‘bad’ cholesterol &fats
SIDE EFFECT
Cause gallstones, liver problems,nausea,vomiting
Stomach pain

14. BRAND NAME

15. Thank You
!!!! A.K