Gm mosquitoes to fight malaria

1. GM mosquitoes to
fight malaria
Gene-editing tech to create genetically altered
mosquitoes may be out there in five years,
says Bill Gates
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2. Contd…
Bring on the genetically modified mosquitoes, Bill Gates says. In recent years,
biolo gists armed with a new gene editing technology have proposed altering
mosquitoes so they're more resistant to diseases like malaria and dengue.
Using a mechanism known as a `gene drive', researchers say they can quickly
push an alteration through an entire species. “In less than five years, I think
there's a good chance it will be out there,“ Gates said in an interview before
speaking at a conference of the American Society for Microbiology in
Boston.In normal reproduction, a mosquito carrying one copy of an altered
gene passes it on to 50% of its offspring. In a gene drive, an engineered
segment of DNA is inserted in the mosquito that causes nearly 100% of the
offspring to inherit the altered gene, dramatically increasing the rate of
spread.
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3. Contd…
“Gene drives, over the next three to five years will be developed in a
form that will be extremely beneficial for knocking down“ mosquito
populations, Gates said. “Of course, that makes it a key tool to reduce
malaria deaths.“
Controversial Approach
Scientists have said they've successfully created malaria-resistant
mosquitoes in a lab that passed on the trait to 99.5% of their progeny .
While the technology may work, it's controversial. Some researchers
have warned that gene drives may not be safe -what if the targeted
species cross-breed with another organism?
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4. Contd…
What if released mosquitoes develop spontaneous, unintended
mutations? -and have called for more regulation. “My basic belief is
that children dying of malaria is a bad thing, and that we should be
able to meet these objections,“ Gates said. “But there's still a fair bit of
work to be done.“
Through the Bill and Melinda Gates Foundation, the Microsoft
cofounder has waged a lengthy battle against malaria, committing
almost $2 billion in grants since 2000. There were about 214 million
malaria cases and 438,000 deaths from the disease in 2015, according
to the World Health Organization.
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