Editing of pig dna could lead to more human organs

1. Editing of pig DNA could lead
to more human organs
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2. Contd…
This month, scientists gathered at the National Academy of Sciences in
Washington to talk about Crispr, a new method for editing genes. Among
those describing recent advances was one of Crispr's pioneers, George
Church of Harvard Medical School. In the midst of his presentation, Dr
Church dropped a bombshell. In a typical experiment, scientists use Crispr to
alter a single gene. But in recent work with pig cells, Dr Church and his team
used it to alter 62 genes at once. The researchers hope that this achievement
may make it possible to use pig organs for transplantation into humans. In
the 1990s, researchers explored the possibility of using pig organs in
humans, a technique known as xenotransplantation. They hoped that pig
organs could be cleansed of viruses and other pathogens that might harm
their human hosts. Dr Fish man of the Massachusetts General Hospital and
other researchers have been looking for ways to overcome this hurdle,
without much success.
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3. Contd…
In 2013, they asked Dr Church if he would be game to edit the genes of
the porcine viral genes or PERVs, making them harmless to pig cells,
and thus to humans. Dr Church agreed to give it a shot.
Other attempts to disable PERVs had failed, mangling DNA so badly
that the cells died. But Crispr, it turned out, is well suited to the
task.“Dr Church's work brings us closer to a realization of a limitless
supply of safe, dependable pig organs for transplant,“ said Dr David A
Dunn, an expert on transplantation at the State University of New York.
He predicted that future research might lead to PERVfree pig clones,
which could help find an entirely new line of pigs whose organs would
be safer for human transplantation.
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