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• These are also called as Psychotomimeties, Psychedelics,
Psychodysleptics, Psychotogens
• These are drugs which alter mood, behaviour, thought and perception
in a manner similar to that seen in psychosis.
• The important ones are :
• INDOLE AMINES --- Eg: Lysergic acid diethylamide (LSD)
Lysergic acid amide
Psifocybin
Harmine
• PHENYLALKYLAMINES ---- Eg: Mescafine
Ecstasy
• ARYLCYCLOHEXYL AMINES ------ Eg: Phencyclidine .
• CANNABINOID -------------------- Eg: Tetrahydrocannabinol
3. 1. Lysergic acid diethylamide (LSD):
• It is Synthesized by Hofmann who was working on chemistry of ergot
alkaloids, and himself experienced its hallucinogenic effect.
• It is the most potent psychedelic, 25-50 pg produces all the effects.
• In addition to the mental effects, it produces pronounced central
sympathetic stimulation.
• Its action appears to involve serotonergic neuronal systems in brain.
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4. Ecstasy
• Methylene dioxy methamphetamine (MDMA) is an amphetamine-like
synthetic compound with stimulant and hallucinogenic propertres,
that has been abused as a recreational and euphoriant drug.
• Other synthetic phenylalkylamines with hallucinogenic property are-
• Dimethoxymethyl amphetamine (DOM) and
• Methylene dioxyamphetamine (MDA) .
• High doses and repeated use of amphetamine can also cause
psychosis
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