Rna editing and r rna processing

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mRNA editing and rRNA processing . the details are discussed in this file by NARAYAN SARKAR, Msc botany ,GAUHATI UNIVERSITY ,GUWAHATI, ASSAM

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Marine and terrestrial biogeochemical models are key components of the Earth System Models (ESMs) used toproject future environmental changes. However, their slow adjustment time also hinders effective use of ESMsbecause of the enormous computational resources required to integrate them to a pre-industrial equilibrium. Here,a solution to this "spin-up" problem based on "sequence acceleration", is shown to accelerate equilibration of state-of-the-art marine biogeochemical models by over an order of magnitude. The technique can be applied in a "blackbox" fashion to existing models. Even under the challenging spin-up protocols used for Intergovernmental Panelon Climate Change (IPCC) simulations, this algorithm is 5 times faster. Preliminary results suggest that terrestrialmodels can be similarly accelerated, enabling a quantification of major parametric uncertainties in ESMs, improvedestimates of metrics such as climate sensitivity, and higher model resolution than currently feasible.

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Large language models (LLMs) are in the spotlight. Laypeople are aware of and are using the LLMs such as OpenAI’s ChatGPT and Google’s Gemini on a daily basis. While companies are exploring new business opportunities, researchers have gained access to an unprecedented scientific playground that allows for fast experimentation with limited resources and immediate results. In this talk, using concrete examples from requirements engineering, I am going to put forward several research opportunities that are enabled by the advent of LLMs. I will show how LLMs, as a key example of modern AI, unlock research topics that were deemed as too challenging until recently. Then, I will critically discuss the perils that we face when it comes to planning, conducting, and reporting on credible research results following a rigorous scientific approach. This talk will stress the inherent tension between the exciting affordances offered by this new technology, which include the ability to generate non-factual outputs (fiction), and our role and societal responsibility as information scientists.

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TheCarringtoneventof1859hasbeenthestrongestsolarflareintheobservationalhistory.ItplaysacrucialroleinsheddinglightonthefrequencyandimpactsofthepastandfutureSolarEnergeticParticle(SEP)eventsonhumansocieties.WeaddresstheimpactoftheCarringtoneventbymeasuringtree‐ring14Cwithmultiplereplicationsfromhigh‐latitudelocationsaroundtheeventandbycomparingthemwithmid‐latitudemeasurements.Atransientoffsetin14Cfollowingtheeventisobservedwithhighstatisticalsignificance.Ourstate‐of‐the‐art14Cproductionandtransportmodeldoesnotreproducetheobservationalfinding,suggestingfeaturesbeyondpresentunderstanding.Particularly,ourobservationwouldrequirepartiallyfasttransportof14Cbetweenthestratosphereandtroposphereathighlatitudes.TheobservationisconsistentwiththepreviousfindingswiththeSEPeventsof774and993CEforwhichfasterintegrationof14Cintotreeringsisobservedathighlatitudes

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HIV (human immunodeficiency virus) is a virus that attacks cells that help the body fight infection, making a person more vulnerable to other infections and diseases. It is spread by contact with certain bodily fluids of a person with HIV, most commonly during unprotected sex (sex without a condom or HIV medicine to prevent or treat HIV), or through sharing injection drug equipment. Seasonal influenza (the flu) is an acute respiratory infection caused by influenza viruses. It is common in all parts of the world. Most people recover without treatment. Influenza spreads easily between people when they cough or sneeze. Vaccination is the best way to prevent the disease. Symptoms of influenza include acute onset of fever, cough, sore throat, body aches and fatigue. Treatment should aim to relieve symptoms. People with the flu should rest and drink plenty of liquids. Most people will recover on their own within a week. Medical care may be needed in severe cases and for people with risk factors. There are 4 types of influenza viruses, types A, B, C and D. Influenza A and B viruses circulate and cause seasonal epidemics of disease. Influenza A viruses are further classified into subtypes according to the combinations of the proteins on the surface of the virus. Currently circulating in humans are subtype A(H1N1) and A(H3N2) influenza viruses. The A(H1N1) is also written as A(H1N1)pdm09 as it caused the pandemic in 2009 and replaced the previous A(H1N1) virus which had circulated prior to 2009. Only influenza type A viruses are known to have caused pandemics. Influenza B viruses are not classified into subtypes but can be broken down into lineages. Influenza type B viruses belong to either B/Yamagata or B/Victoria lineage. Influenza C virus is detected less frequently and usually causes mild infections, thus does not present public health importance. Influenza D viruses primarily affect cattle and are not known to infect or cause illness in people.

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This edition of our Newsletter is a testament to our collective dedication and the exciting progress we’ve achieved. The completion of our first Periodic Report marks a significant milestone, and the advancements in tetrahedrite mineral-based thermoelectric materials are not just promising -they are a lap towards a sustainable future. We’re excited to share updates on our ongoing activities, our synergistic collaborations with the EHRASE cluster and THERMOS project, and insightful technical information on thermoelectric generators. But that’s not all, join us on the Consortium Tour, where this time SGUDS and IGME-CSIC take centre stage. Plus, don’t miss the insightful interview with Doug Crane from our Scientific Advisory Board, whose expertise enriches our understanding of thermoelectrics. This edition also features the fascinating adventures of Starty, exploring the practical uses of thermoelectric devices in a narrative that’s both educational and engaging. Looking ahead, we eagerly anticipate your visit to the START booth at the upcoming 40th International and 20th European Thermoelectric Conference, ICT/ECT 2024, in Krakow. We hope this Newsletter serves not only as a source of information but also as an inspiration for continued excellence. Stay connected with us for more exciting updates from START on our website and social media channels.

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In recent years, the growth of scientific data and the increasing need for data sharing and collaboration in the field of environmental chemistry has led to the creation of various software and databases that facilitate research and development into the safety and toxicity of chemicals. The US-EPA Center for Computational Toxicology and Exposure has been developing software and databases that serve the chemistry community for many years. This presentation will focus on several web-based software applications which have been developed at the USEPA and made available to the community. While the primary software application from the Center is the CompTox Chemicals Dashboard almost a dozen proof-of-concept applications have been built serving various capabilities. The publicly accessible Cheminformatics Modules (https://www.epa.gov/chemicalresearch/cheminformatics) provides access to six individual modules to allow for hazard comparison for sets of chemicals, structure-substructure-similarity searching, structure alerts and batch QSAR prediction of both physicochemical and toxicity endpoints. A number of other applications in development include a chemical transformations database (ChET) and a database of analytical methods and open mass spectral data (AMOS). Each of these depends on the underlying DSSTox chemicals database, a rich source of chemistry data for over 1.2 million chemical substances. I will provide an overview of all tools in development and the integrated nature of the applications based on the underlying chemistry data. This abstract does not necessarily represent the views or policies of the U.S. Environmental Protection Agency.

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ManganesehasbeenobservedonMarsbytheNASACuriosityroverinavarietyofcontextsand isanimportantindicatorofredoxprocessesinhydrologicsystemsonEarth.WithintheMurrayformation,an ancientprimarilyfine‐grainedlacustrinesedimentarydeposit inGalecrater,Mars,haveobservedupto45× enrichmentinmanganeseandupto1.5×enrichmentinironwithincoarsergrainedbedrocktargetscomparedto themeanMurraysedimentcomposition.Thisenrichment inmanganesecoincideswiththetransitionbetween twostratigraphicunitswithintheMurray:SuttonIsland, interpretedasalakemarginenvironment,andBlunts Point,interpretedasalakeenvironment.OnEarth,lacustrineenvironmentsarecommonlocationsofmanganese precipitationduetohighlyoxidizingconditionsinthelakes.Here,weexplorethreemechanismsfor ferromanganeseoxideprecipitationatthislocation:authigenicprecipitationfromlakewateralongalakeshore, authigenicprecipitationfromreducedgroundwaterdischargingthroughporoussandsalongalakeshore,and earlydiageneticprecipitationfromgroundwaterthroughporoussands.All threescenariosrequirehighly oxidizingconditionsandwediscussoxidantsthatmayberesponsiblefortheoxidationandprecipitationof manganeseoxides.Thisworkhasimportant implicationsforthehabitabilityofMarstomicrobesthatcould haveusedMnredoxreactions,owingtoitsmultipleredoxstates,asanenergysourceformetabolism.

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From their humble beginnings in 1984, TED has grown into the world’s most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world. With over one billion views in a year, it’s no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively. The article “5 Public-Speaking Tips TED Gives Its Speakers”, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage. Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience. See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers See the original article on Forbes here: http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9b

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Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world. Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance. For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age. Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage.

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