Short presentation On folic acid

1. FOLIC ACIDFOLIC ACID
Presented By:Presented By:
NABIN PANDITNABIN PANDIT
Nepal Institute Of Health SciencesNepal Institute Of Health Sciences
Jorpati, KathmanduJorpati, Kathmandu
Diploma In PharmacyDiploma In Pharmacy
33rdrd
YearYear
Roll No:15Roll No:15

2. FOLIC ACIDFOLIC ACID
 Folic acid is also called vitamin(B9) is involved in maturation ofFolic acid is also called vitamin(B9) is involved in maturation of
red blood cell and synthesis of purines and pyrimidines which arered blood cell and synthesis of purines and pyrimidines which are
required for development of fetal nervous system.required for development of fetal nervous system.
 Adequate folic acid is intake before conception and through firstAdequate folic acid is intake before conception and through first
trimester of pregnancy helps prevents certain brain and spinaltrimester of pregnancy helps prevents certain brain and spinal
cord defects.cord defects.
 Folate is absorbed in the duodenum and upper jejunum.Folate is absorbed in the duodenum and upper jejunum.
 The US recommended daily dose is 400 microgram and upperThe US recommended daily dose is 400 microgram and upper
limit is 1000 microgram.limit is 1000 microgram.
 Folate is essentially nontoxic. Deficiency produces megaloblasticFolate is essentially nontoxic. Deficiency produces megaloblastic
anemia. A deficiency of folate in old age significantly increase theanemia. A deficiency of folate in old age significantly increase the
risk of developing dementia.risk of developing dementia.
 Folic acid is found in dried peas, dried beans, yeast, and leafyFolic acid is found in dried peas, dried beans, yeast, and leafy
green vegetable, eggs ,meats.green vegetable, eggs ,meats.

3. Chemical Structure Of Folic AcidChemical Structure Of Folic Acid
 IUPACIUPAC name:N-[(4-{[(2-amino-4-oxo-1,4-name:N-[(4-{[(2-amino-4-oxo-1,4-
dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-
glutamic acidglutamic acid

4. Physical propertiesPhysical properties
 State: Crystalline powder having 5-85%State: Crystalline powder having 5-85%
waterwater
 Odor: OdorlessOdor: Odorless
 Taste : TastelessTaste : Tasteless
 Solubility: Soluble in dilute mineral NaoHSolubility: Soluble in dilute mineral NaoH
giving clear orange brown solution and it isgiving clear orange brown solution and it is
insoluble in cold water.insoluble in cold water.
 Color: Yellow to yellowish orange colorColor: Yellow to yellowish orange color

5. Stability/StorageStability/Storage :It is stored in air tight container:It is stored in air tight container
protected from light.protected from light.
UsesUses : It is used in treatment of megaloblastic anemia.: It is used in treatment of megaloblastic anemia.
 It is used in folic acid deficiency.It is used in folic acid deficiency.
 It is also used in vitamin/mineral supplementationIt is also used in vitamin/mineral supplementation
during pregnancy/lactation.during pregnancy/lactation.
Adverse Effects:Adverse Effects: Folic acid supplementation isFolic acid supplementation is
generally thought to be safe for human use. However,generally thought to be safe for human use. However,
in rare cases, allergic reactions have occurred.in rare cases, allergic reactions have occurred.
Patients experiencing any signs or symptoms of aPatients experiencing any signs or symptoms of a
severe allergic reaction including hives, difficulty insevere allergic reaction including hives, difficulty in
breathing or swallowing, and shortness of breath.breathing or swallowing, and shortness of breath.

6. ThankThank You!!!You!!!
Any Questions???Any Questions???

7. ThankThank You!!!You!!!
Any Questions???Any Questions???