The document discusses several anti-patterns when building distributed systems with Akka actors including: using global mutable state accessible by multiple actors; flat actor hierarchies without proper boundaries; having too many isolated actor systems instead of using custom dispatchers for bulkheading; logging in a way that negatively impacts performance; and not understanding hardware configurations can lead to suboptimal systems. The presentation provides alternatives such as immutable messaging, building hierarchies, using custom dispatchers, Akka's logging facilities, and hardware-aware configurations.