Full description of Ashoka Drug , and it is very use full document

1. “Ashoka”
PRESENTATION ON :-
A S H O K A - A M E D I C I N A L H E R B A L P L A N T
Prepared by :- No
WADIWALA SRUSHTI 75
RAIYANI MALHAR 106
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2. ASHOKA TREE
DRUG CLASS TANNINS
MARKER COMPOUND CATECHIN
PARTS ARE USED STAM BARK, SEEDS, FLOWER,
LEAF
USES 1)GYNACOLOGICAL DISORDER
2)RELIVE OF PAIN DURING
MENSTRUATION
3)LEUCORRHOEA
ASHOKA
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A S H O K A - A M E D I C I N A L H E R B A L P L A N T

3. ASHOKA TREE
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4. ASHOKA PLANT VARIOUS PARTS
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5. BARK MAINLY OLD STEM IS DARK
BROWN MARKED BY GREY, ASH
WHITE PATHCHES OF LICHENS.
LEAF 15 CM LONG AND OBLONG SHAPE
FLOWER POLYGAMOUS, YELLOWISH
ORANGE AND SCARLET
SEED ELLIPSOID-OBLONG AND
COMPRESSED.FLOWERING AND
FRUITING OCCUR FORM JULY TO
OCTOMBER
BASIC MORPHOLOGY
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A S H O K A - A M E D I C I N A L H E R B A L P L A N T

6. A S H O K A - A M E D I C I N A L H E R B A L P L A N T
ASHOKA TREE
(MALIBA PHARMACY COLLEGE)
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7. • Drug consists of dried stem bark of Saraca
asoca (Roxb.)
• Belonging to family :-
Fabaceae
(Synonyms :- indica Linn)
BIOLOGICAL NAME
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8.  Gujarati-
Ashopalava
 Hindi-
Ashok, Asok, Sita ashok
 English-
Asok tree
 Sanskrit-
Anganapriya, Apashaka, Ashoka, Gandapushpa,
Hemapushpa, Madhupushpa, Pindapuspa,
Pindipushpa, Vanjula, Vichita, Vishoka
VERNACULAR NAMES
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9.  Assam. – Ashoka
 Beng. – Ashok
 Eng. – Asok tree
 Guj. – Ashoka
 Hind. – Ashoka
 Kan. – Ashokamara
 Kash. – Ashok
 Mal. – Asokam
 Mar. – Ashok
 Ori. – Ashoka
 Punj. – Asok
 Tam. – Asogam
 Tel. - Ashokam
COMMON NAME
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10.  Ashok is grown in India, Burma, and
Malaysia, Pakistan, Usa, Srilanka
 In India, it can be found especially in
Himalayas, (Ascending to 600 m), Kerala,
and Bengal and entire south region. It is
a rain –forest tree.
 The original distribution is in the central
areas of the Deccan Plateau and the
Western Ghats and Western coastal zone.
GEOGRAPHICAL SOURCE
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11. DESCRIPTION
DESCRIPTION
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12. Size :- Width – 2 to 4 cm
Thickness – 5 to 8 mm
Length – varying
Surface :- Outer side – transversely ridged and exhibit circular
. protuberances containing lenticels.
Inner side – reddish brown, longitudinal striated.
Fracture :- Short and Fibrous
Taste :- Astringent
Odor :- Not specific
Shape :- Occurs in form of channels
MACROSCOPIC CHARACTERISTICS :-
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13. MICROSCOPIC CHARACTERISTICS :-
A S H O K A - A M E D I C I N A L H E R B A L P L A N T
https://link.springer.com/chapter/10.1007/978-1-4614-
9515-4_4
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14. 1. Periderm consisting of 10 to 25 layers of cork traversed
with few groups of stone cells.
2. 3 to 4 layers of phellogen and serveral layers of cortex
interspersed with groups of sclereids.
3. Pericycle wide, composed of scattered groups of
sclereids forming one or two continuous band towards
peripheral region.
4. Phloem is composed of groups of phloem is composed
of groups of phloem fibres running in tangential bands
alternating with parenchyma and sieve tissue, often
getting obliterated into bands of ceratenchyma.
MICROSCOPIC CHARACTERISTICS :-
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15. 5. Medullary rays uniseriate, getting 5 to 12 cell wide
towards its peripheral region, contain groups of
prismatic crystals of calcium oxalate.
6. Idioblasts containing prismatic crystals of calcium
oxalate are associated with the sclereids of cortex and
pericycle and phloem fibers.
7. Starch grains are present through out parenchymatous
cells of the section and tannins in cortex.
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16. A, cork fragment; B, prisma of calcium oxalate; C, sclereids with idioblast
containing prism; D, radially cut of phloem region; E, crystal fibres P, prism of
calcium oxalate; mr , medullary rays; phf, phloem fibres; sg, starch grains; stc,
stone cells ccp, cell containing fragment.
MICROSCOPIC CHARACTERISTICS OF POWDER:-
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17.  Major :-
• Tannins: ( + ) catechin,
Leucocyanidin,
( - ) epicatechin,
Leucopelargonidin,
Procyanidin B-2,
11’-deoxyprocyanidin B
CHEMICAL CONSTITUENTS
A S H O K A - A M E D I C I N A L H E R B A L P L A N T
catechin
Leucocyanidin,
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18.  Minor:-
• Beta-Sitosterol,
24-ethylcholest-5,
24-methylcholest-5-en-3 beta-ol,
22-dien-3 beta-ol,
24-ethylcholest-5-en-3 beta-ol
A S H O K A - A M E D I C I N A L H E R B A L P L A N T
Beta-Sitosterol
24-ethylcholest-5,
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19. TLC:-
• Test solution:-
Extract 1gm of powdered drug with methanol(3*15 ml) by cold
maceration for 15 min. Filter the methanolic extract, concentrate and make
up the volume to 10 ml.
• Standard solution:-
Dissolve 10 mg of (+) catechin* in 100 ml of methanol in a volumetric flask.
• Prodedure:-
Apply 10 μl of test solution and standard solution of (+) catechin separately
on precoated silica gel 60 F254 plate of uniform thickness of 0.2 mm.
Develop the plate in the solvent system to a distance of 8cm.
IDENTITY TEST
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20. • Visualization:-
Spray the plate with anisaldehyde-sulphuric acid
reagent and heat the plate at 70 degree till the
coloured bands develop. Note the R1 and colour of
the resolved bands.
• Evaluation:-
A band (Rf 0.57) corresponding to (+) catechin is
visible in both standard and test solution tracks.
A S H O K A - A M E D I C I N A L H E R B A L P L A N T
[ TLC profile of test solution of saraca asoca stem bark ]
1 : Test solution; 2 : (+)-catechin standard
2
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21. Rf value Colour of the band
0.24 Brown
0.32 Brown
0.40 Light brown
0.57 Brown [(+) catechin]
0.64 Violet
0.70 Light blue
0.76 Yellow
0.77 Light blue
0.82 Light purple
0.89 Light purple
0.92 Light purple
TLC DETAILS OF TEST
SOLUTION
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22. • TLC densitometric estimation (+) catechin.
 Solvent system-
• Toluene : Ethyl acetate : Formic acid : menthol: (3 : 3 : 0.8 : 0.2).
 TLC plates-
• Procoated silica gel 60 F254 of uniform thickness of 0.2mm.
 Scanning-
• Under Uv light at 278 nm.
 Standard solution-
• Dissolve 10 mg of (+) catechin in 100 ml of methanol in a volumetric
flask. From this stock solution prepare standard solution of 24 to 72
microgram/ml by transferring aliquots (6 to 18 ml) of stock solution to
25 ml volumetric flask and adjusting the volume to 25 ml with methanol.
ASSAY / ANALYTICAL METHOD
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23.  Test solution-
• Take 1 gm of powdered drug in a conical flask and extract with
methanol (4*25 ml). Pool the methanol extracts, concentrate and
makeup the volume to 25 ml with methanol.
 Calibration curve-
• Apply 10 μl of the standard solution (240 to 720 ng per spot) on a
precoated TLC plate. Develop the plate in the solvent system in twin
trough chamber to a distance of 8cm. Scan the plates
densitometrically at 278 nm. Record the peak area and prepare the
calibration curve by plotting peak area vs concentration of (+)
catechin applied.
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24. A S H O K A - A M E D I C I N A L H E R B A L P L A N T
A. (+) catechin standard ;
B. Test solution of test solution of asoca stem bark
• Calibration curve:-
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25.  FOREIGN MATTER : Not more than 2.0 per cent
 ASH : Not more than 0.6 per cent.
 ACID-INSOLUBLE ASH : Not more than 0.6 percent
 ETHANOL-SOLUBLE EXTRACTIVE : Not less than 11.0 per cent.
 WATER-SOLUBLE EXTRACTIVE : Not less than 10.5 per cent.
QUANTITATIVE STANDARDS
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26. • Apply 20 μl of the test solution in triplicate on a
precoated TLC plate. Develop the plate in the solvent
system and record the peak area of the chromatogram as
described above for the calibration curve. calculate the
amount of (+) catechin present in the sample from the
calibration curve of (+) catechin which is shown in a
figure.
• The percentage of (+) catechin ranges from 0.038 to 0.083
in the samples analyzed.
ESTIMATION OF (+)CATECHININ THE DRUG
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27. • Stimulant effect on uterus
• Uterine Concentration
• Stimulation effect on endometrial and ovarian tissue
• Myotropic action due to phenolic glycoside P2
• Cholinergic activity due to non- phenolic glycoside
PHARMACOLOGY
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28. • Antimicrobial activity
• Anticancer activity
• Ant oxytocic activity
• Anti-inflammatory activity
• Uterine tonic activity
• Analgesic activity
PHARMACOLOGICAL ACTION
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29. 1. Ashoka each part in tree is proven medicinal value and
cures disorders; hence it is called Ashoka.
2. The barks, seeds and fiowers of the tree are helpful in
preparing capsules, ointments and tonics to solve various
gynecological problems of women also used as a natural
supplement of great benefit to irritations and burning
sensation in the skin and complexion.
3. It is also reduces excessive and painful bleeding,
leucorrhea and headache for women Because of
chloroform and methanol properties.
4. the bark is used to cure bactrial and fungal infection.
5. Ashoka can use for bleeding caused due to piles.
USES
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30. A S H O K A - A M E D I C I N A L H E R B A L P L A N T
6. Powder form Ashoka seed cures kidney stones.
7. The ground seed is also used as memory enhancer
8. The paste of the seed is used for urine retention
9. The ash preapred form Ashoka trees cures rheumatoid
arthitis and joint pain.
10. bark helps in removing worms and comforts form
swelling of the stomach.
11. Dried flowers are used cure diabetes. It adds ease for
indigestion.
12. Medicine prepared form leaves, flowers and barks are
used to cure diarrhea and purification of blood.
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31.  Stem bark of :-
1. Bauhinia variegata Linn.,
2. Brownea ariza Benth.,
3. Polyalthia longifolia (sonn.) Thw.,
4. Shorea robusta Gaertn.f., Trema orientalis(linn.) blume
ADULTERANTS / SUBSTITUTES
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32.  Major Therapeutic Claims:-
• Hemmorhagic disorders of ulterus.
 Safety Aspects:-
• The drug used traditionally in prescribed doses may be considered
safe
 Dosage:-
• 20 to 30 gm of the drug for decoction.
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33. • Ashoka is wonderful
and widely used
ingredient in this
natural supplement for
female health .
• Ashoka is grief and
Ashoka means one that
relieves the pain or
grief of a women.
• Ashoka helps to
maintain female’s
overall health.
A S H O K A - A M E D I C I N A L H E R B A L P L A N T
1. ASHOKA POWDER
 Marketed products :-
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34. • Pradrantak Chrna is
complete herbal formulation
to take of female health
problems.
• It is particularly effective in
painful menstruation, pre-
menstrual syndrome,
irregular menses uterine
fibrosis, ovarian cysts and
leucorrhoea.
• This product naturally
balances disturbed female
hormones.
A S H O K A - A M E D I C I N A L H E R B A L P L A N T
2. PRADARANTAK CHURNA
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35. • This product has its roots in
ashoka herbal healthcare system
of india.
• According to Ayurveda the
balance of 3 energies VATA
,PITTA, KAPHA is in the body.
• The product control the
“vata”causes irregular painful
menstrution.
• it disturb “pitta the themal
energy’ Excess “pitta causes
heavy bleeding ,hot flushes and
irritability.
A S H O K A - A M E D I C I N A L H E R B A L P L A N T
3. FEMALE HEALTH SUPPORT
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36. • Aurvedic tonic benificial for
women Anti-inflammatory
• Healing properties
• Appetizing
• Anti- oxidant properties
• DOSAGE(ADULTS): 1 to 2
Tablespoon
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A S H O K A - A M E D I C I N A L H E R B A L P L A N T
4. DABAR ASHOKA

37. • Uterine Tonic
• In Fertility
• Menstrual Cycle Disorder
• Facial Radiance
• Restore the Natural Hormonal
Balance
• DOSE: 2 tablespoon, 3 times a
day with Fresh Water
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A S H O K A - A M E D I C I N A L H E R B A L P L A N T
ASHOKA NARI

38. • Menosan possesses
phytoestrogens, which act as
natural selective estrogen receptor
modulators (SERMs). SERMs
selectively inhibit or stimulate
estrogen-like action in various
tissues.
• he drug is useful in the prevention
and management of
postmenopausal cardiovascular
diseases and osteoporosis
• Menosan also has antioxidant and
antimicrobial properties.
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A S H O K A - A M E D I C I N A L H E R B A L P L A N T
ASHOKA TABLETS

39. ASHOKA CAPSULES
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A S H O K A - A M E D I C I N A L H E R B A L P L A N T

40. 1. Pharmacognosy of indigenous drugs, vol.1. Compiling &
ed. Raghunathan K, Mitra R, New Delhi; Central council
for Research in Ayurveda & Siddha; 1999; p. 119-139
2. Indrani N, Balasubramaniam K.isolation of condensed
tannins from saraca ashoka.part i. Leather Sci 1984; 31;
349-351
3. Kaur DJ, Misra K. Leucoanthocynidins from Saraca
asoca stem bark. J Indian Chem Soc 1980; 57; 1243; Chem
Abster 1981; 94; 80249s
REFERENCES
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41. • http://www.planetayurveda.com/library/ashoka-saraca-asoca
• https://www.homeremediess.com/ashok-medicinal-plant-
uses-and-pictures/
• http://www.alwaysayurveda.com/ashoka/
• http://www.himalayastore.com/pharmaceuticals/menosan-
tablets.htm
• https://www.exportersindia.com/goldwater-
india/products.htm
• https://www.amazon.com/DR-WAKDES®-Ayurvedic-
Supplement-multiples/dp/6040337877
REFERENCES
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42. A S H O K A - A M E D I C I N A L H E R B A L P L A N T
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