Biophysics ofbreathing fin

Biophysics of breathing. Spirography Lectures on Medical Biophysics Department of Biophysics, Medical Faculty, Masaryk University in Brno

Lecture outline ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Respiratory movements ,[object Object],[object Object],[object Object],[object Object]

Diffusion of O 2 and CO 2 in plasma ,[object Object],[object Object],[object Object],0.022 O 2 (Water: 0.013; Fat : 0.065) N 2 0.018 C O 0.52 C O 2 Bunsen coefficients of solubility (  ) for gases in blood under normal body temperature. The unit of solubility is (ml of gas under normal temperature and pressure)  (ml of blood) -1  (101.3 kPa) -1

Gas exchnage 6 . 7 4 . 0 Living cell - diffusion Capillary wall cellular membrane 5 . 5 6 . 0 12 . 7 5 . 3 streaming Blood circulation: arteries veins - diffusion alveolar-capillary wall 5 . 2 13 . 3 streaming alveoli pCO 2 (kPa) pO 2 (kPa) Way of transport Medium

Exchange of O 2 and CO 2 Alveolus Tissue

Changes of negative pleural pressure during respiration

Respiratory volumes and capacities ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Idealised spirogram V [l] V [l]

Respiratory resistances ,[object Object],[object Object],[object Object]

Respiratory work ,[object Object],[object Object],[object Object],[object Object],Respiratory work . A) – during inspiration , B) – during expiration . Area 0ACD0 – elastic work done at the expense of body energy ( during inspiration ) or at the expense of potential energy of distended elastic tissues ( during expiration ). Area ABCA represents active inspiration work against the non-elastic resistance . Area ACEA represents the work against the non-elastic resistance during expiration at the expense of body energy ( after Pil a wsk i ).

How to calculate respiratory work? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Measurement of respiratory volumes - spirography

Spirogram We can measure the dependence of volume on time or Flow rate on volume Flow rate [litres]

Some biophysical aspects of breathing ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Author: Vojtěch Mornstein Content collaboration and language revision: Carmel J. Caruana Presentation design: not yet Last revision: September 200 8

Biophysics ofbreathing fin

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Biophysics ofbreathing fin