Growth hormone is secreted by the anterior pituitary gland and regulates growth. It is released in response to growth hormone-releasing hormone and growth hormone-inhibiting hormone from the hypothalamus. Growth hormone promotes growth in organs and tissues, favors fat metabolism over carbohydrates, and works through insulin-like growth factors. Too much or too little growth hormone can lead to gigantism, acromegaly, or dwarfism. Prolactin is a hormone secreted by the pituitary gland that causes milk production and has inhibitory effects on reproductive functions. Dopamine agonists like cabergoline are used to treat hyperprolactinemia and some types of acromegaly by inhibiting prolactin secretion.

1. GROWTH HORMONE
AND
PROLACTIN

2. GROWTH HORMONE
Secreted from anterior pitutary,it’s a growth
regulating hormone
Releasing and release inhibitory in hypothalamus
It is an acidophill(cells get stained pink)
191 aminoacid,single chain peptide having MW
22000
GHRH andGHIH released into pituitary via
hypothalamohypophyseal portal system

3. •Promotes growth of all organs including
hyperplasia
•Growth of brain and eye are independent
•Promotes retention of nitrogen
•Utilises fat first by sparing carbohydrates
•Growth mediators=IGF-1 and IGF-
2(stomatomedins)
•GH accentuates metabolic dearrangement in
diabetes

4. •Excess production leads to gigantism and
acromegaly in adults
•Hyposecretion results into dwarfism
•Recombinant GH is available
•GH deficient patient increases lean body mass
and decreases body fat
•Severe inflammation,chronic renal
failure,osteoporosis may occur

6. •Its 14 aminoacid chain
•Produced by hypothalmus, pancreas
•Inhibits secretion of
GH,prolactin,insulin,glucagon etc
•Beneficial for fistu;as of pancreas,intestine
•Constricts splanchnic,hepatic and renal blood
vessels
•Used to control bleeding from esophageal varices

7. •It’s a synthetic octapeptide
•Congener of stomatostasin
•Longer actin and 40 times more potential
•Preferred over stomatostatin in acromegaly,AIDS
or in esophageal varices

8. •It’s a peptide chain of 198 amino acid
•Hormone that causes secretion of milk
•Promotes profileration of ductal and acinar
cells in breast
•Inhibitory effect on hypothalmo-hypophyseal
gonadal axis
•Causes lactational amenorrhea
•Inhibits ovulation and produces infertility
•It has action on T-lymphocytes
•PRIH- dopaminergic

10. •Potent dopamine agonist
•Greater acyion on D2 receptors
•Not an oxytocic
•Partial agonist or antagonist of D1 receptor
•Antigalactopoietic
•Increases GH release but decreases from
pituitary tumors
•Has levodopa like actions
•Produces nausea and vomiting
•Hypotension
•Decreases gastrointestinal motility

11. USES:-
•In hyperprolactinemia
•Alternative srug for acromegaly
•Adjuvant drug in parkinsoniasm

12. •Bromocriptine congener
•More potent
•More selective on D2 receptor
•Largely superseded bromocriptine
In treatment of acromegaly and
hyperprolactinemia

13. THANK
YOU!!