Megaloblastic anaemia is a type of anaemia characterized by the formation of unusually large, abnormal and immature red blood cells called as megaloblasts by the bone marrow, which are released into the blood. To know more visit here: www.lazoi.com

1. Symptoms | Causes | Diagnosis | Treatment | Preventions
Megaloblastic Anaemia

2. What is Megaloblastic Anaemia ?
Megaloblastic anaemia is a type of anaemia characterized by the
formation of unusually large, abnormal and immature red blood
cells called as megaloblasts by the bone marrow, which are
released into the blood.

3. Causes of Megaloblastic Anaemia
 Vitamin B12 deficiency
 Folate deficiency
 Drugs
 Myelodysplastic syndromes
 Acute leukemia

4. Symptoms of Megaloblastic
Anaemia
 shortness of breath
 muscle weakness
 abnormal paleness of the skin
 glossitis (swollen tongue)
 loss of appetite/weight loss
 diarrhea
 nausea
 fast heartbeat
 smooth or tender tongue
 tingling in hands and feet
 numbness in extremities

5. Diagnosis of Megaloblastic Anaemia
 Peripheral Blood Smear
 Bone Marrow Biopsy
 Serum Cobalamin
 Serum Folate
 Serum Methylmalonate and Homocysteine
 Routine Blood Count

6. Treatment of Megaloblastic Anaemia
Vitamin B-12 Deficiency: In the case of megaloblastic anemia
caused by vitamin B-12 deficiency, you may need monthly
injections of vitamin B-12. Oral supplements may also be given.
Adding more foods with vitamin B-12 to your diet can help. Foods
that have vitamin B-12 in them include:
 eggs
 chicken
 fortified cereals (especially bran)
 red meats (especially beef)
 milk
 shellfish

7. Treatment Continue…
Folate Deficiency: Megaloblastic anemia caused by a lack of folate
may be treated with oral or intravenous folic acid supplements.
Dietary changes also help boost folate levels. Foods to include in
your diet include:
 oranges
 leafy green vegetables
 peanuts
 lentils
 enriched grains

8. Preventions of Megaloblastic
Anaemia
 Avoid alcohol.
 Make sure you are receiving adequate iron in your diet.
 Take a vitamin B supplement several times a week if you take
medication that reduces stomach acid.

9. Diet of Megaloblastic Anaemia
Sources of folic acid:
 Legumes, nuts, whole grain cereals, yeast
 Green vegetables, broccoli, asparagus, okra, cauliflower, and brussel
sprouts.
 Oranges, carrots, and cantaloupe.
Sources of B-12:
 Animal products:
Meat, eggs, milk
 Vitamin supplements

10. Diet Continue…
Sources of thiamine:
 Dried peas, beans, legumes, peanuts, and peanut butter
 Green leafy vegetables
 Nuts
 Protein-rich foods: meat
 Wheat germ, whole grain bread and cereal

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