Some inhibitors of translation and transcription...

1. TRANSLATION INHIBITORS
In prokaryotes:-
1. Tetracycline:-inhibit A site (small subunit of ribosome)
2. Erythromycin:-inhibit peptide exit groove (large subunit of
ribosome)
3. Chloramphenicol:- inhibit peptidyl transferase activity of 23 s
rRNA (peptide bond formation)
4. Puromycin:-inhibit at A site (codon –anticodon interaction
inhibited)
5. Fusidic acid:-inhibit translation activity of elongation factor EF –G
(at GDP state)

2. IN EUKARYOTES :-
1. CYCLOHEXIMIDE:-INHIBIT PEPTIDYL TRANSFERASE ACTIVITY OF 28S RRNA(PEPTIDE BOND
FORMATION)
2. DIPTHERIA TOXIN:-INHIBIT A SITE (SMALL SUBUNIT OF RIBOSOME)
BOTH INHIBITED (PROKARYOTES & EUKARYOTES)
1. HYGROMYCINB:- INHIBIT A SITE(SMALL SUBUNIT OF RIBOSOME)
2. PUROMYCIN:- INHIBIT A SITE (SMALL SUBUNIT OF RIBOSOME)---PREMATURE TERMINATION
3.SARICINEAND RICIN
THANK YOU …LALIT PARASTE