The document outlines plans for primary care networks (PCNs) in England for 2021-22 and 2022-23, focusing on improving prevention, patient outcomes, access, and outcomes for patients on medication. It discusses changes to the 2021-22 Network DES and new funding of £43 million allocated based on need to support PCN leadership. An investment and impact fund of £150 million in 2021-22 and £225 million in 2022-23 is outlined with requirements around cardiovascular disease prevention, tackling health inequalities, and anticipatory care.