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Biochemical Aspects Of Cell
Beginning of life on earth is still a mystery !  BUT ,[object Object],[object Object],[object Object]
Cell is Structural & Functional Unit of an Organism All organisms are made up of cells ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Different types of cells are different in their minute Structure & Functions  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Fundamental Structural and Functional Organisation of all cells are Similar ,[object Object]
Why We Need To Understand Cells? ,[object Object],[object Object],[object Object],[object Object],[object Object]
Why?  The Study of cell is a logical starting point of medical education. ,[object Object],[object Object],[object Object],[object Object]
Thorough Knowledge of Structure and Function of cell is Necessary to Understand Modern aspects of medical sciences like: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Living Systems Have Different Levels of Organization. ,[object Object],[object Object],[object Object],[object Object],[object Object]
Tissue Cell Organs System
Structural Organization of Animal Cell ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Compartments in Protoplasm ,[object Object],[object Object],[object Object],[object Object]
Cytoplasm & Nucleoplasm Have Fluid Part and Insoluble Structures ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
CYTOPLASM ,[object Object],[object Object],[object Object]
Components of Cytoplasm ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cytosol is the  Fluid component of Cytoplasm Excluding Organelles and the Insoluble Components.
Organic  Solutes of Cytosol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],Inorganic  Solutes of Cytosol
Functions of Cytoplasm ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],Supporting Functions of Cytoplasm
[object Object],[object Object],Cytoplasm is Site for Most cellular activities
Functions of a Multicellular Organism such as, Growth , Reproduction, Respiration, Excretion etc. are the Ultimate Result of Individual Cellular Activities ,[object Object],[object Object],[object Object]
Vital Functions ,[object Object],[object Object],[object Object]
Specified Functions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Two Major Requirements For Cell Functions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cellular Function are Based on Metabolism ,[object Object],[object Object],[object Object],[object Object]
Purpose of metabolic reaction may be: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cellular Activities Required to Maintain Normal Life are Based on Specific Metabolic Processes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Many  Other Cellular Activities are also Required to Maintain Normal Life ,[object Object],[object Object],[object Object],[object Object]
Many  Other Cellular Activities are also Required to Maintain Normal Life ,[object Object],[object Object],[object Object]
Overall Behaviour of Human body is Collaborated Functions of Organs ,[object Object]
Specific Cellular Activities are Performed In Different Compartments Of Cell ,[object Object],[object Object],[object Object],[object Object],[object Object]
Specific Cellular Activities In Cytosol ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Organelles Are Metabolic Machinery of the Cell ,[object Object],[object Object],[object Object]
Metabolic machinery of the cell:  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ORGANELLES
All Organelles have unique functions and perform specific jobs ,[object Object],[object Object],[object Object],[object Object],[object Object]
Mitochondrion (Chondriosome) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Mitochondrion Matrix Inter Membrane Space Outer Membrane Inner Membrane  Folded Inside To Form Cristae
Mitochondrion Energy yielding metabolic processes    Biological Oxidation (Respiratory Chain).    Oxidative Phosphorylation.  Citric Acid Cycle.  Oxidation of Fatty Acids. CO, CN and other deadly Poisons cause Death because they block the energy yielding reactions in Mitochondria.
Cut Section of Mitochondrion
Mitochondria (Chondriosomes) are Powerhouse of cells ,[object Object],[object Object],[object Object],[object Object]
Mitochondria are site for many other Specific Cellular Activities  ,[object Object],[object Object],[object Object]
Mitochondrial Medicine ,[object Object]
Mitochondrial Diseases (Mitochondrial Cytopathies) ,[object Object],[object Object],[object Object]
Depending on which cells of the body are affected, Mitochondrial Diseases may result in: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Endoplasmic Reticulum is Interconnected Network of branching canals and vesicles
Endoplasmic Reticulum is Interconnected Network of: Tubules Vesicles Sacs (Cisternae)
Two Types Of Endoplasmic Reticulum ,[object Object],[object Object],Ribosomes
Endoplasmic Reticulum is Membrane Bound Organelle Involved in  Synthesis of Proteins & other Compounds ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
RER Is the Site for Protein Synthesis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Each cell contains thousands Miniature “Protein Factories” The Ribosomes ,[object Object],[object Object],[object Object],[object Object],[object Object]
A ribosome is a small, dense, functional structure found in all known cells that assemble proteins ,[object Object],[object Object],[object Object],[object Object]
Ribosomes Are Embedded On Surface Of ER Or Found Free In Cytoplasm ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Protein Synthesis Can be Interrupted By External Factors ,[object Object],[object Object],[object Object],[object Object]
The Smooth ER Has a Wide Range Of Functions ,[object Object],[object Object],[object Object],[object Object]
The Rough and Smooth ER Are Usually Interconnected ,[object Object]
ER & Intracellular Transport ,[object Object],[object Object],[object Object],[object Object],[object Object]
Golgi Apparatus (Golgi Body or Golgi Complex) Network of membranous tubules and vesicles present in most living cells
Golgi Apparatus is  In Direct connection with ER ,[object Object],[object Object],[object Object]
Golgi Apparatus is involved in secretory functions of cells ,[object Object],[object Object],[object Object],[object Object]
Lysosomes are Small and Simple Membranous Sacs,  Contain Digestive Enzymes. Membrane Enzymes
Lysosome is a cellular organelle responsible for intracellular digestion and recycling of macromolecules. ,[object Object],[object Object],[object Object],[object Object],[object Object]
Lysosomes: Autolysis of Dead Cell Material ,[object Object],[object Object],[object Object]
Lysosomes have about 40 different types of digestive enzymes ,[object Object],[object Object],[object Object]
[object Object],[object Object],Lysosomes: Defence against living Bacteria
Lysosomes Allow the Cell to   Recycle the Valuable Nutrients ,[object Object],[object Object],[object Object]
Why Don't Lysosomes Digest the Cell? ,[object Object],[object Object]
Diseases Due to Absence of Lysosomal Enzymes ,[object Object],[object Object],[object Object]
Lysosomal Storage Diseases (LSD) are due to absence or deficiency of enzyme(s) ,[object Object],[object Object],[object Object]
Excessive Storage of Molecules is the Major Hazard of LSDs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Common clinical findings in LSDs ,[object Object],[object Object],[object Object],[object Object],[object Object]
Lysosomes are involved in Programmed Cell Death: Apoptosis.  ,[object Object],[object Object]
The Lysosomsal  Membrane Allows Only Small Particles To Exit It. ,[object Object],[object Object]
INCLUSIONS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],Cytoskeleton of of Cytoplasm Maintain Cell Shape & Motility
Cell Has The Ability to Move During Various Conditions ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],Cell motility involves physical forces generated by Cytoskeleton
[object Object],[object Object],[object Object],[object Object],The Cytoskeleton is Like a Little Highway Infrastructure Inside The Cell.
Other Important Functions Of CYTOSKELETON ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CELL MEMBRANE  (Plasma Membrane, Cytomembrane or Plasmalemma) ,[object Object],[object Object],[object Object],[object Object],[object Object]
CELL WALL ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],NUCLEUS
Nucleus is Responsible For Overall Behavior of the Cell. ,[object Object],[object Object],[object Object]
Genetic Material is Organized as Chromatin  ,[object Object],[object Object]
Chromatin is a DNA-protein complex  ,[object Object],[object Object],[object Object]
CHROMOSOMES ,[object Object],[object Object],[object Object]
Each DNA Molecule is Made up of Many Genes ,[object Object]
Genetic Diseases ,[object Object],[object Object],[object Object]
Examples Of Genetic Diseases ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
NUCLEOLUS ,[object Object],[object Object],[object Object]
Vacuoles A number of small cavities in the cytoplasm of a cell, bound by a single membrane and containing water, fat, or metabolic waste.
Prokaryotic  & Eukaryotic Types on the Basis of Development ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cell  Types  On the Basis of Development ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Prokaryotic Cell ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Eukaryotic Cell ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Cell

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  • 17. Cytosol is the Fluid component of Cytoplasm Excluding Organelles and the Insoluble Components.
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  • 39. Mitochondrion Matrix Inter Membrane Space Outer Membrane Inner Membrane Folded Inside To Form Cristae
  • 40. Mitochondrion Energy yielding metabolic processes  Biological Oxidation (Respiratory Chain).  Oxidative Phosphorylation.  Citric Acid Cycle.  Oxidation of Fatty Acids. CO, CN and other deadly Poisons cause Death because they block the energy yielding reactions in Mitochondria.
  • 41. Cut Section of Mitochondrion
  • 42.
  • 43.
  • 44.
  • 45.
  • 46.
  • 47. Endoplasmic Reticulum is Interconnected Network of branching canals and vesicles
  • 48. Endoplasmic Reticulum is Interconnected Network of: Tubules Vesicles Sacs (Cisternae)
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  • 59. Golgi Apparatus (Golgi Body or Golgi Complex) Network of membranous tubules and vesicles present in most living cells
  • 60.
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  • 62. Lysosomes are Small and Simple Membranous Sacs, Contain Digestive Enzymes. Membrane Enzymes
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  • 91.
  • 92. Vacuoles A number of small cavities in the cytoplasm of a cell, bound by a single membrane and containing water, fat, or metabolic waste.
  • 93.
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