This powerpoint is about the mannich reaction i.e.,formation of a beta amino ketone... It's helpful for JAM/NET/GATE/Polytechnic trb aspirants.. Follow me on youtube CHE-MYSTERY Subscribe and press bell button for notification

1. MANNICH REACTION
CHE-MYSTERY
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NAVEEN K
II-M.Sc CHEMISTRY,
St. JOSEPH’S
COLLEGE(AUTONOMOUS),
TRICHY-620002.

2. Mannich reaction
• In mannich reaction, formaldehyde is condensed with ammonia, in the form of its
salt and a compound containing an active hydrogen.
• This can formally be considered as an addition of ammonia to give H2NCH2OH,
followed by a nucleophilic substitution.
• Instead of ammonia, the reaction can be carried out with salts of primary or
secondary amines, or with amides.
• The reaction of a ketone, formaldehyde, and diethylamine with microwave
irradiation gave the Mannich product, a beta-amino ketone.

3. Mechanism

4. Example

5. Example

6. Thank You
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