2. Esophageal cancer.
A, Adenocarcinoma
usually occurs
distally and, as in
this case, often
involves the gastric
cardia. B, Squamous
cell carcinoma is
most frequently
found in the midesophagus, where it
commonly causes
strictures.
3. Esophageal cancer. A, Esophageal
adenocarcinoma organized into back-to-back
glands. B, Squamous cell carcinoma composed
of nests of malignant cells that partially
recapitulate the organization of squamous
epithelium.
4. UNCOMMON ESOPHAGEAL TUMORS
• Other malignancies of the esophagus include unusual forms of
adenocarcinoma, undifferentiated carcinoma, carcinoid tumor,
melanoma, lymphoma, and sarcoma.
• Benign tumors of the esophagus are generally mesenchymal in origin and
arise within the esophageal wall. Tumors of smooth muscle origin,
leiomyomas, are most common; fibromas, lipomas, hemangiomas,
neurofibromas, and lymphangiomas also occur. Some benign tumors take
the form of mucosal polyps. These are usually composed of fibrous and
vascular tissue, or adipose tissue, and are known as fibrovascular polyps
or pedunculated lipomas, respectively. Squamous papillomas are sessile
lesions with a central core of connective tissue and a hyperplastic
papilliform squamous mucosa. Uncommonly, papillomas are associated
with HPV infection, in which case the term condyloma applies. In rare
instances a mass of inflamed granulation tissue, growing either as an
inflammatory polyp or an infiltrative mass in the wall of the esophagus,
may resemble a malignant lesion. These benign lesions are called
inflammatory pseudotumors.