For educational purpose.

1. Topic: Topical & Transdermal Drug Delivery
System
Name: Muhammad Haider Ali
Roll No: 43

2. 1- Topical Drug Delivery System:
DEFINITION:
A topical drug delivery system is a way to deliver
medication that is applied onto a particular part of the
body, typically the skin, to treat various ailments e.g.
(acne).

3. Types of topical drug delivery system:
 Includes two types of topical drug delivery system.
 External: spread or dispersed on the cutaneous surface
 Internal: applied to mucous membranes e.g. eye(conjunctiva),
ear, nasal cavity.
 Classification based on physical state.
 Solid: Powder, aerosol, plasters.
 Liquid: lotion, liniment, solution, emulsion, suspension.
 Semisolid: ointment, cream, paste, gel, suppository.

4. Advantages:
 Avoidance of first pass metabolism.
 Easy application.
 Avoidance of the risks and inconveniences of administration.
 Achievement of efficacy with lower total daily dosage of drug
by continuous drug input.
 Avoids fluctuation in drug levels.
 Easy termination of medications when needed.
 Relatively large area of application.
 Drug can be delivered more selectively to a specific site.

5. Continued:
 Avoidance of gastro-intestinal incompatibility.
 Provide utilization of drugs with short biological half life.
 Improve patient compliance.
 Suitable for self medication.

6. Disadvantages:
 Skin irritation.
 Poor permeability of some drugs through the skin.
 Possibility of allergic reactions.
 Enzymes in epidermis may denature the drug.
 Drugs with larger particle size are difficult to get absorb
through the skin.

7. 2- Transdermal drug delivery system:
DEFINITION:
 Transdermal drug delivery is defined as a self contained
discrete dosage form, which when applied to the intact skin,
will deliver the drug at a controlled rate to the systemic
circulation.
 Also defined as medicated adhesive patch that is placed on
the skin to deliver a specific dose of medication through the
skin and into the blood stream.

8. Examples:

9. Advantages:
 Easy to use.
 Avoid GIT absorption problems for drugs.
 Avoids first pass metabolism of drugs.
 More improved and convenient patient compliance.
 Rapid termination in case of toxicity is possible.
 Self medication is possible.
 Reduces the frequency of dosing.

10. Disadvantages:
 Daily dose of more than 10 mg is not possible.
 Local irritation is a major problem.
 Drug requiring high blood levels are unsuitable.
 Drug with long half life cannot be formulated in TDDS.
 Uncomfortable to wear.
 Barrier function changes from person to person and within
the same person.

11. Thank You