This document outlines an Industrial Ecology Quality Management System (IEQMS) that is aligned with ISO standards and incorporates principles of Industrial Ecology, Green Engineering, and Green Chemistry. The IEQMS provides guidance for organizations to systematically implement processes and procedures to achieve the goals of Industrial Ecology, including more sustainable product design, prevention of waste, use of renewable resources, and continual improvement. Key elements of the IEQMS include incorporating Industrial Ecology principles into operations, design, monitoring, management review, and promoting innovation to further sustainability goals. Appendices provide more details on the relationships between various Industrial Ecology, Green Engineering and Green Chemistry principles and how they map to the IEQMS framework and PDCA cycle.

1. IEQMS
Industrial Ecology Quality Management System
ON ISO ANNEX SL

2. IEQMS - Industrial Ecology Quality Management System - ONISO ANNEX SL - Pag. i a 15

3. IEQMS - Industrial Ecology Quality Management System- ON ISO ANNEX SL - Pag. ii of 15
TABLE OF CONTENTS
0 INTRODUCTION 4
0.1 General 4
1 SCOPE 5
2 NORMATIVE REFERENCES 5
3 TERMS AND DEFINITIONS 5
4 CONTEXT OF THE ORGANIZATION 5
4.1 Understanding the organization and its context 5
4.2 Understanding the needs and expectations of interested parties 5
4.3 Determining the scope of the quality management system 5
4.4 Quality management system and its processes 5
5 LEADERSHIP 6
5.1 Leadership and commitment 6
5.2 Policy 6
5.3 Organizational roles, responsibilities and authorities 6
6 PLANNING 6
6.1 Actions to address risks and opportunities 6
6.2 Quality objectives and planning to achieve them 6
6.3 Planning of changes 6
7 SUPPORT 6
7.1 Resources 6
7.2 Competence 7
7.3 Awareness 7
7.4 Communication 7
7.5 Documented information 7
8 OPERATION 7
8.1 Operational planning and control 7
8.2 Requirements for products and services 8
8.3 Design and development of products and services 8
8.4 Control of externally provided processes, products and services 9
8.6 Release of products and services 10
8.7 Control of non-conforming outputs 10

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9 PERFORMA NCE EVALUATION
9.1
10
Monitoring, measurement, analysis and evaluation 10
9.2 Internal audit 11
9.3 Management review 11
10 IMPROVEM EN T
11
10.1 General 11
10.2 Nonconformity and corrective action 11
10.3 Continual improvement 11
APPENDIX A: GREEN ENGINEERING AND GREEN CHEMSTRY PRINCIPLES 122
APPENDIX B: RELATIONSHIP GREEN ENGINEERING AND GREEN CHEMISTRY 133
APPENDIX C: PRINCIPLES OF INDUSTRIAL ECOLOGY IN THE DEMING CYCLE 144
APPENDIX D: CONTRIBUTORS TO THE GUIDE IEQMS ON ANNEX SL 155

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0 INTRODUCTION
0.1 General
IEQMS - Industrial Ecology Quality Management System
In green text (CI - Industrial Ecology), contains the principles of Industrial Ecology.
In order to supply companies of a method to improve and to standardize their activities toward
sustainability, this Guide has been implemented with a specific part dealing with Industrial
Ecology, in order to be able to manage a gap analysis, new projects and the review of the existing
ones with a view to an increasingly sustainable future.
Industrial Ecology consists of Green Engineering and Green Chemistry and it is a universally
codified roadmap to design or redesign more efficient, safer, cleaner, less wasted chemical
reactions and processes.
In specific, Green Chemistry (12 principles) deals with chemical transformations by considering
the efficient use of resources, the reduction of hazard, unhealthiness and environmental impact,
while Green Engineering (9 Principles) takes care to design efficient processes and systems, to
ensure that industrial installations are innovative and compatible, and to carry out system and
impact analysis.
Specifically, Industrial Ecology is the «study of the human productive, environmental and socio-
cultural system, based on an interdisciplinary approach, for the evaluation of the impacts that
industrial activities have on the availability of natural resources, on the capacity of the
environment to absorb discards and on the ecosystems, for the planning and the
environmentally friendly management of the productive systems».
Each principle has been positioned in this Guide at the applicable point. In addition, a specific
diagram (Appendix A) shows how each principle is in relation with the PDCA cycle and the
related points of the Guide. There are nine more boxes (identified by uppercase letters from «A»
to «I») reporting operations of support for the system analysis and the improvement. The
diagram also shows where and when LCA (Life Cycle Assessment) and Responsible Care
analysis should come into play.
Industrial Ecology Quality Management System (IEQMS) is thus defined as a Quality
Management System documenting processes, procedures, and responsibilities for the
achievement of the contents of Industrial Ecology principles.
The IEQMS helps to drive an organization to comply with the requirements of Green Engineering
and Green Chemistry and to improve its effectiveness and efficiency with a view to a continual
improvement.
Although the respect of the Industrial Ecology principles is without a doubt desirable for any
industrial activity, it is meaningless its debasement by turning it into score checklists. The
respect of these principles has instead to be oriented towards a new and virtuous approach
which evaluates all the principles, if and where applicable, always with a holistic vision.
Also, sustainability must not be confused or assimilated with the «natural origin» or «natural
derivation». Indeed, many processes from which «synthetic products» derive, are much more
sustainable than processes from which the so-called «natural products» originate. Sustainability
and naturality are two different and non-overlapping evaluation criteria with different purposes.

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1 SCOPE
---
2 NORMATIVE REFERENCES
---
3 TERMS AND DEFINITIONS
---
4 CONTEXT OF THE ORGANIZATION
4.1 Understandingthe organizationandits context
CI - Industrial Ecology
Green Engineering Principle #7
RESPECT
Development and application of engineering solutions should consider local geography,
aspirations, and cultures.
4.2 Understandingthe needsandexpectationsof interestedparties
CI - Industrial Ecology
Green Engineering Principle #1
ENGINEERING
The organization shall engineer processes and products holistically, use systems analysis and
integrate environmental impact assessment tools.
Green Engineering Principle #9
INVOLVEMENT
The organization should actively engage communities and stakeholders in the development of
engineering solutions.
4.3 Determiningthe scope of the quality management system
No additional requirements
4.4 Qualitymanagement system and its processes
CI - Industrial Ecology
Green Chemistry Principle #1
PREVENTION OF WASTE
The organization should consider the prevention of waste.
It is better to prevent waste than to treat or clean up waste after it is formed.
The organization should:
 Consider the effect of the overall process on the choice of chemistry;
 Recognize where safety and waste minimization are incompatible;
 Monitor, report, and minimize laboratory waste emitted.

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5 LEADERSHIP
5.1 Leadershipandcommitment
5.1.1 General
No additional requirements
5.1.2 Customer focus
No additional requirements
5.2 Policy
5.2.1 Establishing the quality policy
CI - Industrial Ecology
Top management should establish, implement and maintain a Quality Policy that considers what
follows.
Green Engineering Principle #2
PROTECT AND IMPROVEMENT
Includes a commitment to conserve and improve natural ecosystems while protecting human
health and well-being.
Green Engineering Principle #6
PREVENTION
Includes a commitment to prevent waste.
5.2.2 Communicating the quality policy
No additional requirements
5.3 Organizationalroles,responsibilitiesandauthorities
No additional requirements
6 PLANNING
6.1 Actions to addressrisks and opportunities
No additional requirements
6.2 Quality objectivesandplanningto achieve them
No additional requirements
6.3 Planning of changes
No additional requirements
7 SUPPORT
7.1 Resources No additional requirements

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7.1.1 General
No additional requirements
7.1.2 People
No additional requirements
7.1.3 Infrastructure
No additional requirements
7.1.4 Environment for the operating of processes
No additional requirements
7.1.5 Monitoring and measuring resources
7.1.5.1 General
No additional requirements
7.1.5.2 Measurement traceability
No additional requirements
7.1.6 Organizational knowledge
No additional requirements
7.2 Competence
No additional requirements
7.3 Awareness
No additional requirements
7.4 Communication
No additional requirements
7.5 Documentedinformation
7.5.1 General
No additional requirements
7.5.2 Creating and updating
No additional requirements
7.5.2.2 Creating and updating records
No additional requirements
7.5.3 Control of documented information
No additional requirements

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8 OPERATION
8.1 Operationalplanningand control

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CI - Industrial Ecology
Green Chemistry Principle #11
POLLUTION PREVENTION ANALYSIS
The organization should develop analytical methodologies to allow for real-time and in-process
monitoring and control to prevent formation of hazardous substances.
Green Chemistry Principle #12
MINIMIZATION OF CHEMICAL ACCIDENT RISK
Substances and the form of a substance used in a chemical process should be chosen so as to
minimize the potential for chemical accidents, including releases, explosions, and fires.
The organization should establish, implement, control and maintain the processes needed to
meet Industrial Ecology requirements.
[A] OPERATIONAL CONTROL
Top management leads by ensuring that process activities that were identified as having
significant Industrial Ecology impacts or legal requirements put operational controls in place.
Operational controls may be in the form of operating procedures, preventative maintenance,
equipment controls, etc.
[B] OPERATIONAL FOLLOW UP
The organization should aim an operational follow up to allow data collection, follow-up,
analysis and optimization of critical processes.
8.2 Requirementsforproductsand services
8.2.1 Customer communication
No additional requirements
8.2.2 Determination of requirements for products and services
No additional requirements
8.2.3 Review of the requirements for products and services
No additional requirements
8.2.4 Changes to requirements for products and services
No additional requirements
8.3 Designand developmentofproductsand services
CI - Industrial Ecology
Green Engineering Principle #3
DESIGN
The organization should use Life-Cycle thinking in all design activities.
Green Chemistry Principle #2
ATOMIC ECONOMY
Methods should be designed to maximise reaction yield and reaction yield assessment.
Synthetic methods should be designed to maximize the incorporation into the final product of
all materials used in the process.

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The organization should:
 Identify and quantify by-products;
 Report conversions, selectivity, and productivity;
 Establish full mass balances for a process;

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 Measure catalyst and solvent losses in aqueous effluent;
Green Chemistry Principle #3
LESS DANGEROUS CHEMICAL SYNTHESIS
Wherever practicable, synthetic methodologies should be designed to use and generate
substances that possess little or no toxicity to human health and to the environment.
Green Chemistry Principle #4
DESIGN OF HEALTHY CHEMICAL COMPOUNDS
Chemical products should be designed to preserve efficacy of function while reducing toxicity.
Green Chemistry Principle #5
MORE HEALTHY SOLVENTS AND AUXILIARIES
The use of auxiliary substances (e.g., solvents, separation agents) should be made unnecessary
whenever possible and innocuous when used.
The organization should minimize/remove solvents and unhealthy separation agents.
Green Chemistry Principle #6
DESIGN FOR ENERGY EFFICIENCY
Energy requirements should be recognized for their environmental and economic impacts and
should be minimized.
Synthesis methods should be conducted preferably at ambient temperature and pressure.
Green Chemistry Principle #8
LIMITATION OF DERIVATIVES
The organization should minimize/eliminate unnecessary derivatizations (blocking group,
protection/deprotection, temporary modification of physical/chemical processes) to limit
additional reagents and waste.
Green Chemistry Principle #9
SELECTION CATALYSIS
The organization should prefer selective catalytic reagents.
Catalytic reagents (as selective as possible) are superior to stoichiometric reagents.
Green Chemistry Principle #10
DESIGN FOR DEGRADATION
Chemical products should be designed so that at the end of their function they do not persist in
the environment and break down into innocuous degradation products.
8.4 Controlof externallyprovidedprocesses,productsand services
8.4.1 General
CI - Industrial Ecology
Green Engineering Principle #4
GUARANTEES
The organization should ensure that all material and energy inputs and outputs are as inherently
safe and benign as possible.
Green Chemistry Principle #7

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RENEWABLE RAW MATERIALS
The organization should prefer raw materials and precursors from renewable sources
A raw material feedstock should be renewable rather than depleting whenever technically and
economically practical.

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8.4.2 Type and extent of control
No additional requirements
8.4.3 Information for external providers
No additional requirements
8.5 Production and service provision
8.5.1 Control of production and service provision
No additional requirements
8.5.2 Identification and traceability
No additional requirements
8.5.3 Property belonging to customers or external providers
No additional requirements
8.5.4 Preservation
No additional requirements
8.5.5 Post-delivery activities
No additional requirements
8.5.6 Control of changes
No additional requirements
8.6 Release of products and services
No additional requirements
8.7 Controlofnon-conforming outputs
No additional requirements
9 PERFORMANCE EVALUATION
9.1 Monitoring,measurement,analysis and evaluation
9.1.1 General
CI - Industrial Ecology
Green Engineering Principle #5
MINIMIZATION
The organization should minimize depletion of natural resources.
[C] MEASUREMENT
[D] DATA COLLECTION
When determining what should be monitored and measured the organization should take into
account the Industrial Ecology principles, compliance obligations and operational controls.
The methods used by the organization to data collection, monitor and measure, analyse and

15. IEQMS - Industrial Ecology Quality Management System- ON ISO ANNEX SL - Pag. 14 of 15
evaluate should be defined in the Industrial Ecology Quality Management System, in order to
ensure that:
a) The timing of monitoring and measurement is coordinated with the need for analysis
and evaluation results;
b) The results of monitoring and measurement are reliable, reproducible and traceable;

16. IEQMS - Industrial Ecology Quality Management System- ON ISO ANNEX SL - Pag. 15 of 15
c) The analysis and evaluation are reliable and reproducible, and enable the organization
to report trends.
9.1.2 Customer satisfaction
No additional requirements
9.1.3 Analysis and evaluation
CI - Industrial Ecology
[E] CORRECTIONS
[F] CONSOLIDATION
[G] STANDARDIZATION
All data collected should be corrected, consolidated and standardized.
9.2 Internalaudit
No additional requirements
9.3 Management review
9.3.1 General
No additional requirements
9.3.2 Management review input
No additional requirements
9.3.3 Managementreview outputs
No additional requirements
10 IMPROVEMENT
10.1 General
No additional requirements
10.2 Nonconformity and corrective action
No additional requirements
10.3 Continualimprovement
CI - Industrial Ecology
Green Engineering Principle #8
INNOVATION AND INVENTION
The organization should improve, innovate, and invent (technologies) to achieve sustainability.
[H] IMPROVEMENT EVALUATION

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[I] PREPARATION FOR A NEW “PLAN”
The rate, extent and timescale of actions that support continual improvement are determined by
the organization. Industrial Ecology performance can be enhanced by applying the Industrial
Ecology Quality Management System as a whole or improving one or more of its elements.

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APPENDIX A: GREEN ENGINEERING AND GREEN CHEMSTRY PRINCIPLES
GREEN ENGINEERING 9 PRINCIPLES
1. ENGINEERING - Engineer processes and products holistically, use systems analysis,
and integrate environmental impact assessment tools.
2. PROTECION AND IMPROVEMENT - Conserve and improve natural ecosystems
while protecting human health and well-being.
3. DESIGN - Use life-cycle thinking in all engineering activities.
4. GUARANTEES - Ensure that all material and energy inputs and outputs are as
inherently safe and benign as possible.
5. MINIMIZATION - Minimize depletion of natural resources.
6. PREVENTION - Strive to prevent waste.
7. RESPECT - Develop and apply engineering solutions, while being cognizant of local
geography, aspirations, and cultures.
8. INNOVATION AND INVENTION - Create engineering solutions beyond current or
dominant technologies; improve, innovate, and invent (technologies) to achieve
sustainability.
9. INVOLVEMENT - Actively engage communities and stakeholders in developm ent of
engineering solutions.
GREEN CHEMISTRY 12 PRINCIPLES
1. PREVENTION OF WASTE - Reduction / elimination production of waste vs
subsequent treatment.
2. ATOMIC ECONOMY - Methods designed to maximize reaction yield and reaction
yield assessment.
3. LESS DANGEROUS CHEMICAL SYNTHESIS - Methods of synthesis for use and
generation of substances with reduced or zero toxicity.
4. DESIGN OF HEALTHY CHEMICAL COMPOUN DS - Minimization of toxicity with
expected function maintenance.
5. MORE HEALTHY SOLVENTS AND AUXILIARIES - Minimization/ removal solvents
and unhealthy separation agents.
6. DESIGN FOR ENERGY EFFICIENCY - Minimization of energy requirements for
environmental and economic impact (preferably room temperature and pressure).
7. RENEWABLE RAW MATERIALS - Preference for raw materials and precursors from
renewable sources.
8. LIMITATION OF DERIVATIVES - Minimization / elimination of unnecessary
derivatizations (blockers groups, protections and de-protections) to limit additional
reagents and waste.
9. SELECTIVE CATALYSIS - Preference for selective catalytic reagents.
10. DESIGN FOR DEGRADATION – No persistence in the environment at the end of the
life-cycle.
11. POLLUTION PREVENTION ANALYSIS - Real-time and in-process monitoring and
control to prevent formation of hazardous substances.
12. ACCIDENTS PREVENTION - Minimization of chemical accident risk (release, fire,
explosion).

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APPENDIX B: RELATIONSHIP GREEN ENGINEERING AND GREEN CHEMISTRY

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APPENDIX C: PRINCIPLES OF INDUSTRIAL ECOLOGY IN THE DEMING CYCLE

21. IEQMS - Industrial Ecology Quality Management System- ON ISO ANNEX SL - Pag. 20 of 15
APPENDIX D: CONTRIBUTORS TO THE GUIDE IEQMS ON ANNEX SL
This Guide wasprepared by:
EFfCI
Vincenzo Paolo Maria Rialdi Vevy Europe S.p.A.